Protein Alignment Ask1 and MAPKKK6

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: NP_187455.1
• Gene: MAPKKK6 / 819989
• AraportID: AT3G07980
• Length: 1367
• Species: Arabidopsis thaliana
• Alignment Length: 671
• Identity: 173/671 - (25%)
• Similarity: 278/671 - (41%)
• Gaps: 158/671 - (23%)

  Fly   555 MILEMTADQVVFVNLSNDDANIEYEYDYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEK 619
            |..:||:.|.      :....::.:|...::     :|||.||.||...|.:....:|||:|..:
plant     1 MARQMTSSQF------HKSKTLDNKYMLGDE-----IGKGAYGRVYIGLDLENGDFVAIKQVSLE 54

  Fly   620 N--SQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLE-TKWGPLKDN 681
            |  .:|:..:.:||.|...|.|:|||:||||........|.:|.|..|||::::: .|:||..
plant    55 NIGQEDLNTIMQEIDLLKNLNHKNIVKYLGSLKTKTHLHIILEYVENGSLANIIKPNKFGPFP-- 117

  Fly   682 ESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTG 746
            ||.:..|..|:||||.|||||.::||||||.|:| .|..|:||::|||.:.:|...:..|.:..|
plant   118 ESLVTVYIAQVLEGLVYLHEQGVIHRDIKGANIL-TTKEGLVKLADFGVATKLNEADFNTHSVVG 181

  Fly   747 TLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEE 811
            |..:||||||:  :.|...|:||||.|||.:|:.|..||:.:| ....|:::: .....|.||:.
plant   182 TPYWMAPEVIE--LSGVCAASDIWSVGCTIIELLTCVPPYYDL-QPMPALYRI-VQDDTPPIPDS 242

  Fly   812 LSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRKVRPALPINTEFGRSISVPADRFVHKTT 876
            ||.:..:|:..||......||.|..||..|::::..|.:|.:|.                 |..|
plant   243 LSPDITDFLRLCFKKDSRQRPDAKTLLSHPWIRNSRRALRSSLR-----------------HSGT 290

  Fly   877 PPLSYNTTCNTPTTPELDITHSSSVDIDELPSNQFMLERRNSH-------GFLLSPEIEPSTPSL 934
              :.|..  .|.::.|.|...|..| ::.:.:.:..:.:.||.       |.....|.:.|:||.
plant   291 --IRYMK--ETDSSSEKDAEGSQEV-VESVSAEKVEVTKTNSKSKLPVIGGASFRSEKDQSSPSD 350

  Fly   935 RTSISETSETDGFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRG 999
            .......||.|      .:|.:..|||              :....:.|:......||    .:|
plant   351 LGEEGTDSEDD------INSDQGPTLS--------------MHDKSSRQSGTCSISSD----AKG 391

  Fly  1000 LRDYIMNENEKH-------------LEATINELKQKLNNDAVALDHLHLALYSFQDAVVCVLRYH 1051
            ....::..:||:             .|...|.|..||.....::...|......:|.
plant   392 TSQDVLENHEKYDRDEIPGNLETEASEGRRNTLATKLVGKEYSIQSSHSFSQKGEDG-------- 448

  Fly  1052 CIKPHWMFALDNLVKRAVQA-------AVTIFS-PELGANL------ADKDLSGNDDESLRTSLM 1102
                         :::||:.       .:|.|| |...|:|      .||...|..:|:
plant   449 -------------LRKAVKTPSSFGGNELTRFSDPPGDASLHDLFHPLDKVPEGKTNEA------ 494

  Fly  1103 QKGSTESQEKQSLEKVLPTSNTREGVGLTPAESGGDALSSSMECARILRDIRDNQQKLQRQLLEQ 1167
               ||.:          ||:|..:|.  :|...||.               .|...||:.::.::
plant   495 ---STST----------PTANVNQGD--SPVADGGK---------------NDLATKLRARIAQK 529

  Fly  1168 QRQSMRALHNISQELAHIYMG 1188
            |.:..........:|..:.||
plant   530 QMEGETGHSQDGGDLFRLMMG 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459
		MAP3K_TRAF_bd	74..445	CDD:463827
		ASK_PH	457..560	CDD:465956	1/4 (25%)
		STKc_ASK	576..843	CDD:270794	103/269 (38%)
		HisK-N-like	948..1079	CDD:466452	22/151 (15%)
MAPKKK6	NP_187455.1	STKc_Cdc7_like	19..274	CDD:270797	103/266 (39%)