DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ask1 and Map3k15

DIOPT Version :9

Sequence 1:	NP_477089.3	Gene:	Ask1 / 42366	FlyBaseID:	FBgn0014006	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	XP_038956496.1	Gene:	Map3k15 / 501558	RGDID:	1560603	Length:	1327	Species:	Rattus norvegicus

Alignment Length:	1331	Identity:	576/1331 - (43%)
Similarity:	786/1331 - (59%)	Gaps:	145/1331 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFG 85
            ||:.:.:|.::.||:...|.|..||||||.||:.||:|||||:|:|.:::|..|.||.||||||.
  Rat    83 ALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDISRQPSLFYHLGVRESFD 147

  Fly    86 MKENILTYNDIDSKQTLSLK--------LSCANYLFLSYKRN--AETNSCHLTSQPNSGNNSKEP 140
            |..|::.|.|.|:...||||        .|..||.|:.|...  |:...|...:| ...:...:|
  Rat   148 MANNVILYYDTDADTALSLKDMVTQKNIASSGNYYFIPYTVTPCADYFCCESDAQ-RRASEYMQP 211

  Fly   141 NAEGRVPTLQW-------------RLKRKLQDVEIQSKAHMREKFLSDMRTARDTYATNGAKLQS 192
            |         |             |....|:|:.:.|.|:.:|..|:|:|.||:.|  .|.:|..
  Rat   212 N---------WDTILGPLCMPLVDRFTTLLKDIRVTSCAYYKETLLNDIRKAREKY--QGDELAK 265

  Fly   193 ILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFA 257
            .|..::.|:|:..||:.:::.:.:.|.||:|||||||:||..||.:| |....:..|:.|.||||
  Rat   266 ELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLP-TCDLADQHNIKFHYAFA 329

  Fly   258 LNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSF 322
            |||||..|||||||:..|:.|...::..|||.|||||||||||::|...:..|...||:|||:.|
  Rat   330 LNRRNSTGDREKALQVMLQVLRSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGF 394

  Fly   323 EVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLA 387
            |:|.:.|:|||||.||::.|::|..:.||:.||:.||:|:|:||||..::.||||..||.:|:||
  Rat   395 ELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLA 459

  Fly   388 NDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNT 452
            :|..||:||||.:||||||.|||:|.:.|:.||.|| |||.....|.:|:: .||:|...||||
  Rat   460 SDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRF-KKPITEHSPRQERL-NFWLDIIFEATN- 521

  Fly   453 EEVKNSIRFPILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKS 517
             ||.|.:|||:|::||.|||.|:||:||.:|:|:::.:.::    :....|:||::.|.||.||.
  Rat   522 -EVTNGLRFPVLVIEPTKIYQPAYVSINNEAEERTVSLWHV----SPTEMKQIHEWNFTASSIKG 581

  Fly   518 VSLYKRDDRCAYLYVHHNSDDFQIYFPSTERRQKFYDMILEMTADQV---VFVNLSNDDANIEYE 579
            :||.|.|:||.:||||.|||||||||.:.|:..:|..::.||..:.|   |.:....|...:|||
  Rat   582 ISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYE 646

  Fly   580 YDYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVR 644
            ||:|....::|||||:||.|||.||...||||||||:||::.:..|||||||.||..|:|||||:
  Rat   647 YDHDVNGERVVLGKGSYGVVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQ 711

  Fly   645 YLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDI 709
            ||||.||||:.|||||||||||||.||.:||||:|  |.|:.||:||||||||||||..||||||
  Rat   712 YLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK--EPTIKFYTKQILEGLKYLHENQIVHRDI 774

  Fly   710 KGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGC 774
            ||||||||||||||||||||||||||.|||.||||||||||||||:||||.||||..|||||.||
  Rat   775 KGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGC 839

  Fly   775 TNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLE 839
            |.:||||.:|||.|||...|||||||.:|.||.|||.|||.|:.|||.||......|.:|:.||:
  Rat   840 TIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQ 904

  Fly   840 DPFLQ--DKPRKVRPALPINTEFGRSISVPADRFVHKTTPPLSYNT-TCNTPTTPELDITHSS-- 899
            :.||:  :|.:|                   :|...|.:..:...| |...|::.||..:.||
  Rat   905 EGFLRQVNKGKK-------------------NRIAFKPSEGVRSGTGTLALPSSGELMGSSSSEH 950

  Fly   900 ---SVDIDELPSNQF----MLERRNSHGFLLSPEIEPSTPSLRTSISETSETD-GFYRLKKDSQR 956
               |.|.|..|...|    :.:.:.||  |||...|.|....|::.....|.| |.:.|:|||:|
  Rat   951 GSISPDSDAQPDAFFEKVQVPKPQLSH--LLSVPDESSALDDRSTALPPEERDPGLFLLRKDSER 1013

  Fly   957 RTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQ 1021
            |..|.::|..:::::.....:.|......:.:....::.:|..|||:|.:...:.:.|||::||.
  Rat  1014 RAILYRILWEEQNQVASNLQECVVQSSEELLLSVGHIKQIIGILRDFIRSPEHRVMAATISKLKV 1078

  Fly  1022 KLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPELGANL-- 1084
            .|:.|:.:::.:||.|:.|||||..:||.|.|:||||||:||:::|||||||.|..|||.|:.
  Rat  1079 DLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVAILIPELQAHFEP 1143

  Fly  1085 ------ADKDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTREGVGLTPAESGGDALSSS 1143
                  .|||.....|..|...|.|            |..:.|..||.| .:...|........|
  Rat  1144 ASETEGVDKDTEMERDYPLVDLLSQ------------EVHVTTRGTRHG-SVAIQEGQPHQQDPS 1195

  Fly  1144 MECARILRDIRDNQQKLQRQLLEQQRQSMRALHNI----SQELAHIYMGGRKRLRRTINGFNKKC 1204
            ::    |..:|....:|...|::::|:....|..|    :|||.|:.:             ..||
  Rat  1196 LQ----LSKLRQETNRLWEHLVQKEREYQNLLRLILEQKTQELYHLQL-------------QYKC 1243

  Fly  1205 HRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSKTLILNEGFTFDD 1269
            :      |||....|             |.|| ..:.:|..||..|.:|..:...|:.|.:|..|
  Rat  1244 N------GGTENPPP-------------HDGL-GTNRELIDWLQLQGVDANTIEKIVEEDYTLSD 1288

  Fly  1270 FIYNMEKLDLMRLGLRVGIEVRLWKLIIQER 1300
            .:.::.|.||..|.||.|:..|||..:.|.|
  Rat  1289 ILNDITKEDLRCLRLRGGVLCRLWHAVSQHR 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020	168/392 (43%)
		STKc_ASK	576..843	CDD:270794	188/266 (71%)
		S_TKc	590..843	CDD:214567	182/252 (72%)
Map3k15	XP_038956496.1	DUF4071	136..514	CDD:404208	168/392 (43%)
		ASK_PH	525..620	CDD:408809	46/98 (47%)
		STKc_ASK	643..908	CDD:270794	188/266 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	274	1.000	Domainoid score	I1703
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H50401
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122434at33208
OrthoFinder	1	1.000	-	-		FOG0001687
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104013
Panther	1	1.100	-	-	LDO	PTHR11584
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920