Protein Alignment Ask1 and MAP3K5

DIOPT Version :9

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: XP_016866359.1
• Gene: MAP3K5 / 4217
• HGNCID: 6857
• Length: 1494
• Species: Homo sapiens
• Alignment Length: 1328
• Identity: 553/1328 - (41%)
• Similarity: 774/1328 - (58%)
• Gaps: 146/1328 - (10%)

  Fly    21 ALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFG 85
            ||:.:::|.::.||..:.:.|.:||||||.||:.|||||:|::::|...:|..|.||.||||||.
Human   221 ALQSLREACETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFS 285

  Fly    86 MKENILTYNDIDSKQTLSLK--------LSCANYLFLSYKRNAETN-SCHLTSQPNSGNNSKEPN 141
            |..||:.|.|.:|....|||        :...||.|:.|....... .|..:|.........:||
Human   286 MANNIILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPN 350

  Fly   142 AE---GRV--PTLQWRLKRKLQDVEIQSKAHMREKFLSDMRTARDTYATNGAKLQSILHEMRKRL 201
            .|   |.:  |.:. |..:.|:..:..|..:.||..|:|:|.||:.|  .|.:|.:.|..:|:|:
Human   351 FELLLGPICLPLVD-RFIQLLKVAQASSSQYFRESILNDIRKARNLY--TGKELAAELARIRQRV 412

  Fly   202 DDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGD 266
            |:..||:.::|.:.:.|.||:||||::|:||..|:.:| |.......::.|.|||||||||..||
Human   413 DNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLP-TFDLASHHHVKFHYAFALNRRNLPGD 476

  Fly   267 REKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAG 331
            |.|||:..:..::.:.....||.||.||||||:|::|::||..|..|...|::::||.:|...:|
Human   477 RAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSG 541

  Fly   332 INLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQA 396
            ||.|.||:..|.:|.::.||:.:|:.|::|:||||:|..|..||:|..|...||||||:.:.|||
Human   542 INYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQA 606

  Fly   397 AECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNTEEVKNSIRF 461
            :|.:||||.|.|||||.:..|.:...|.|...| ||..::::..|||||.:|||.|:  ...:||
Human   607 SEKLFKLKTPAWYLKSIVETILIYKHFVKLTTE-QPVAKQELVDFWMDFLVEATKTD--VTVVRF 668

  Fly   462 PILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDR 526
            |:|||||.|||.|||::||.:.:||:|.|.:: |...|   |.||::.|.||.::.||:.|.::|
Human   669 PVLILEPTKIYQPSYLSINNEVEEKTISIWHV-LPDDK---KGIHEWNFSASSVRGVSISKFEER 729

  Fly   527 CAYLYVHHNSDDFQIYFPSTERRQKFYDMILEMTADQVVFVNLSNDDAN-----IEYEYDYDEQN 586
            |.:|||.||||||||||.:....:||::|:..:|.::    ..|.::.:     :||:|:|||..
Human   730 CCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEK----GRSTEEGDCESDLLEYDYEYDENG 790

  Fly   587 RKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSE 651
            .::||||||||.|||.||...||||||||:||::|:..|||||||.||..|:|:|||:||||.||
Human   791 DRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSE 855

  Fly   652 NGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLV 716
            |||.|||||||||||||.||.:|||||||||.|:.||:|||||||||||:..||||||||||||:
Human   856 NGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLI 920

  Fly   717 NTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMAT 781
            ||||||:||||||||||||.|||.||||||||||||||:||:|.||||.||||||.|||.:||||
Human   921 NTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMAT 985

  Fly   782 GKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQ-- 844
            |||||.|||...|||||||.:|.||.|||.:||.||.|||:||......|..|:.||.|.||:
Human   986 GKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVS 1050

  Fly   845 DKPRKVRPALPI-----NTEFGRSISVPADRFVHKTTPPLSYNTTCNTPTTPELDI------THS 898
            .|.:|.:|.|..     |.|:.||||:|....|..|:....|.:.  :|.| ||.:      |.:
Human  1051 SKKKKTQPKLSALSAGSNAEYLRSISLPVPVLVEDTSSSSEYGSV--SPDT-ELKVDPFSFKTRA 1112

  Fly   899 SSV---DID-------ELPSNQFMLERRNSHGFLLSPEIEPSTPSLRTSISETSETDGFYRLKKD 953
            .|.   |:.       .:|...|     ..|....|||.:.|               ||:.|:||
Human  1113 KSCGERDVKGIRTLFLGIPDENF-----EDHSAPPSPEEKDS---------------GFFMLRKD 1157

  Fly   954 SQRRTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINE 1018
            |:||.||.::|..|:.||....::.:........::...:..||..||:::.:.:.|.:..|:::
Human  1158 SERRATLHRILTEDQDKIVRNLMESLAQGAEEPKLKWEHITTLIASLREFVRSTDRKIIATTLSK 1222

  Fly  1019 LKQKLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPEL--- 1080
            ||.:|:.|:..:..:.:.|:.|||||..|||.|.||||||||||:::::|||.|:||..|||
Human  1223 LKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPH 1287

  Fly  1081 -----GANLAD-KDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTREGVGLTPAESGGDA 1139
                 .::.|| :||...||...:.|    ..|..:.:..:|..:.||    ||....:....|:
Human  1288 FSLASESDTADQEDLDVEDDHEEQPS----NQTVRRPQAVIEDAVATS----GVSTLSSTVSHDS 1344

  Fly  1140 LSS-----------SMECARILRDIRDNQQKLQRQLLEQQRQSMRALHNISQELAHIYMGGRKRL 1193
            .|:           .:|..|:|.::...:::||..|       .||:....||:.|:.:..
Human  1345 QSAHRSLNVQLGRMKIETNRLLEELVRKEKELQALL-------HRAIEEKDQEIKHLKLKS---- 1398

  Fly  1194 RRTINGFNKKCHRMSTSVGGTSGVRP-NIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSK 1257
                                    :| .|...|...||..  |.:..|.:|..||.....||.:.
Human  1399 ------------------------QPIEIPELPVFHLNSS--GTNTEDSELTDWLRVNGADEDTI 1437

  Fly  1258 TLILNEGFTFDDFIYNMEKLDLMRLGLR 1285
            :..|.|.:|..|.:|.:.:.||..|.||
Human  1438 SRFLAEDYTLLDVLYYVTRDDLKCLRLR 1465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020	149/383 (39%)
		STKc_ASK	576..843	CDD:270794	193/266 (73%)
		S_TKc	590..843	CDD:214567	187/252 (74%)
MAP3K5	XP_016866359.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157775
Domainoid	1	1.000	385	1.000	Domainoid score	I815
eggNOG	1	0.900	-	-		E1_KOG4279
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	973	1.000	Inparanoid score	I316
Isobase	1	0.950	-	0	Normalized mean entropy	S2727
OMA	1	1.010	-	-		QHG45642
OrthoDB	1	1.010	-	-		D122434at33208
OrthoFinder	1	1.000	-	-		FOG0001687
OrthoInspector	1	1.000	-	-		otm40380
orthoMCL	1	0.900	-	-		OOG6_104013
Panther	1	1.100	-	-	O	PTHR11584
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.720