Protein Alignment Ask1 and MAP3K15

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: XP_011543809.4
• Gene: MAP3K15 / 389840
• HGNCID: 31689
• Length: 1324
• Species: Homo sapiens
• Alignment Length: 1345
• Identity: 574/1345 - (42%)
• Similarity: 786/1345 - (58%)
• Gaps: 162/1345 - (12%)

  Fly    10 AVGDHLEDRQCALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAIIDLSILTQQRPL 74
            |.|.....|||.|    :|.::.||:...|.|..||||||.||:.||:||||::|:|.:::|..|
Human    76 AGGPEAGARQCLL----RACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDVSRQPSL 136

  Fly    75 SYHYGVRESFGMKENILTYNDIDSKQTLSLK-------------------LSCANYLFLSY--KR 118
            .||.||||||.|..|::.|:|.|:...||||                   .|..||.|:.|  ..
Human   137 FYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTEVFDHNINQFQASSGNYYFIPYIVTP 201

  Fly   119 NAETNSCHLTSQPNSGNNSKEPNAEGRVPTLQWRLKRK----LQDVEIQSKAHMREKFLSDMRTA 179
            .|:...|...:| ...:...:||.:..:..|...|..:    |:|:.:.|..:.:|..|:|:|.|
Human   202 CADYFCCESDAQ-RRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKETLLNDIRKA 265

  Fly   180 RDTYATNGAKLQSILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKY 244
            |:.|  .|.:|...|..::.|:|:..||:.:::.:.:.|.||:|||||||:||..|:.:| |...
Human   266 REKY--QGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDAMVKLVETLEMLP-TCDL 327

  Fly   245 VETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDAT 309
            .:..|:.|.|||||||||..|||||||:..|:.|:..::..|||.|||||||||||::||..|.|
Human   328 ADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDMFCLCGRIYKDIFLDSDCKDDT 392

  Fly   310 SLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEY 374
            |...||:|||:.||:|.:.|:|||||.||::.|::|..:.||:.||:.||:|:|:||||..::.|
Human   393 SRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETSLELRKIGVRLNSLLGRKGSLEKMNNY 457

  Fly   375 WDVATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVF 439
            |||..||.:|:||:|..||:||||.:||||||.|||:|.:.|:.||.||:|...|..|  .::..
Human   458 WDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVWYLRSLVQNLLLIRRFKKTIIEHSP--RQERL 520

  Fly   440 QFWMDFFLEATNTEEVKNSIRFPILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAKNACKK 504
            .||:|...||||  ||.|.:|||:|::||.|:|.||||:||.:|:|:::.:.::    :....|:
Human   521 NFWLDIIFEATN--EVTNGLRFPVLVIEPTKVYQPSYVSINNEAEERTVSLWHV----SPTEMKQ 579

  Fly   505 IHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPSTERRQKFYDMILEM---TADQVVF 566
            :|::.|.||.||.:||.|.|:||.:||||.|||||||||.:.|:..:|:.::.||   ||...|.
Human   580 MHEWNFTASSIKGISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVE 644

  Fly   567 VNLSNDDANIEYEYDYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEI 631
            :....|...:|||||:|....::||||||||.|||.||...||||||||:||::|:..|||||||
Human   645 LEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEI 709

  Fly   632 KLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGL 696
            .||..|:|||||:||||.||||:.|||||||||||||.||.:||||:|  |.|:.||:|||||||
Human   710 ALHKYLKHRNIVQYLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK--EPTIKFYTKQILEGL 772

  Fly   697 KYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVR 761
            |||||..||||||||||||||||||||||||||||||||.:||.||||||||||||||:||||.|
Human   773 KYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPR 837

  Fly   762 GYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAI 826
            |||..|||||.|||.:||||.||||.|||...|||||||.:|.||.|||.|||.|:.|||.||..
Human   838 GYGAPADIWSLGCTIIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEP 902

  Fly   827 SVMDRPSASQLLEDPFLQ---------------DKPRKVRPALPINTEFGRSISVPADRFVHKTT 876
            ....|.:.::||.:.||:               :.||.|..|||...|
Human   903 DPHKRATTAELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGE----------------- 950

  Fly   877 PPLSYNTTCNTPTTPELDITHSS-SVDIDELPSNQFMLERRNSH--GFLLSPEIEPSTPSLRTSI 938
             |::.:::           .|.| |.|.|..|...|...|...|  |.|||...|.|....|...
Human   951 -PMATSSS-----------EHGSVSPDSDAQPDALFERTRAPRHHLGHLLSVPDESSALEDRGLA 1003

  Fly   939 SETSETD-GFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRD 1002
            |...:.| |.:.|:|||:||..|.|:|..:::::.....:.|......:.:....::.:|..|||
Human  1004 SSPEDRDQGLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRD 1068

  Fly  1003 YIMNENEKHLEATINELKQKLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLVKR 1067
            :|.:...:.:..||::||..|:.|:.::..:||.|:.|||||..:||.|.|:||||||:||:::|
Human  1069 FIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRR 1133

  Fly  1068 AVQAAVTIFSPELGANLADKDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTREGVGLTP 1132
            ||||||||..|||.|:.         :.:..|..:.|...|::|                 |..|
Human  1134 AVQAAVTILIPELRAHF---------EPTCETEGVDKDMDEAEE-----------------GYPP 1172

  Fly  1133 AES-GGDALSSSMECARILRDIRDNQQKLQRQLLEQQRQSM----RALHNISQELAHIYMGGRKR 1192
            |.. |.:|.......:..|.::|....:|...|:|::|:..    :.|...:|||.|:.:
Human  1173 ATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQL----- 1232

  Fly  1193 LRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSK 1257
                    ..|.:.::.:..|..|.|                    .|::|..||..|..|  :|
Human  1233 --------KLKSNCITENPAGPYGQR--------------------TDKELIDWLRLQGAD--AK 1267

  Fly  1258 TL--ILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQER 1300
            |:  |:.||:|..|.:..:.|.||..|.||.|:..|||..:.|.|
Human  1268 TIEKIVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYR 1312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459	15/34 (44%)
		MAP3K_TRAF_bd	74..445	CDD:463827	167/395 (42%)
		ASK_PH	457..560	CDD:465956	47/105 (45%)
		STKc_ASK	576..843	CDD:270794	189/266 (71%)
		HisK-N-like	948..1079	CDD:466452	50/130 (38%)
MAP3K15	XP_011543809.4	DRHyd-ASK	86..121	CDD:466459	17/38 (45%)
		MAP3K_TRAF_bd	136..525	CDD:463827	167/394 (42%)
		ASK_PH	536..635	CDD:465956	46/102 (45%)
		STKc_ASK	654..919	CDD:270794	189/266 (71%)
		HisK-N-like	1014..1145	CDD:466452	50/130 (38%)