DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ask1 and Map3k6

DIOPT Version :9

Sequence 1:	NP_477089.3	Gene:	Ask1 / 42366	FlyBaseID:	FBgn0014006	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	XP_006239081.1	Gene:	Map3k6 / 313022	RGDID:	1304625	Length:	1323	Species:	Rattus norvegicus

Alignment Length:	1329	Identity:	489/1329 - (36%)
Similarity:	688/1329 - (51%)	Gaps:	172/1329 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDVVCVMDTAVGDHLE----------DRQCALEEIKQAVQSA--GANFQRVQFERLDFGETNVLE 53
            :.||.|:....|..:|          ..:|..|...| :||.  ....:.:.|..|..|:|..|:
  Rat    46 LSVVYVLTREPGPGVEPGSGTEAEPLPLRCLREACAQ-LQSTRPPPQLRSLPFATLALGDTAALD 109

  Fly    54 TFYNADVAIIDLSILTQQRPLSYHYGVRESFGMKENILTYNDIDSKQTLSLK-------LSC-AN 110
            :||||||.::::|....|..|.||.||||||.|..|:|..:..:.....:|:       ..| .:
  Rat   110 SFYNADVVVLEVSNSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQALREDVFQKNSDCVGS 174

  Fly   111 YLFLSYKRNAE----TNSCHLTSQPNSGNNSKEPNAEGRVPTLQWRLKRKLQDVEIQSKAHMREK 171
            |..:.|...|.    .....|......|........|..:..|..||.|.|:.....|..:.||.
  Rat   175 YTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGVGTEALLTPLVGRLVRLLEATPTDSCGYFRET 239

  Fly   172 FLSDMRTARDTYATNGAKLQSILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLK 236
            ...|:|.||:.:  :|.:|:..|..:::|||...:||.:::.:.:.|.||||||.|::.||..|:
  Rat   240 IRQDIRKARERF--SGQQLRQELARLQRRLDSVELLSPDIIMNLLLSYRDVQDYSAIIELVETLQ 302

  Fly   237 NIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFV 301
            .:| |....|..|:.|.|.||||||||.|||||||...|..::.:....||:.|:|||||||:|.
  Rat   303 ALP-TCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKHEGPVAPDLYCMCGRIYKDMFF 366

  Fly   302 ESDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKG 366
            .|.:.....|..|..|||::|:|:|:.::|||.|.||:..||.|.::||||.|||.|..|:.:||
  Rat   367 SSSFQSTGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGKHFDDSEELQLIGMKLGCLLARKG 431

  Fly   367 SLSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQ 431
            .:..:..||||..:....:||||..:.:.|||.::||..|.|||.|.:....|...||..||...
  Rat   432 CVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVMETFLLYQHFRPTPEPSG 496

  Fly   432 PPIEEQVFQFWMDFFLE------ATNTEEVKNSIRFPILILEPQKIYMPSYVTINMDADEKSIQI 490
            .|:...  .||:.|.|:      ||..:|    .:..:|:||..|:.:|:.:.| ..||..|...
  Rat   497 GPVLRA--HFWLHFLLQSCQPFKATPPQE----DQCLVLVLEINKVLLPARLEI-QGADPMSAVT 554

  Fly   491 VNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPSTERRQKFYDM 555
            :::.....::   ....:.|..:.|..:|..|.|.||.:||....:.|.|:.|||.||.:.|...
  Rat   555 LSLLEPETQD---DPSSWTFPVTSICGISASKLDQRCCFLYALPPAQDVQLCFPSVERCRWFCSQ 616

  Fly   556 ILEMTADQVVFVN----LSNDDAN-----IEYEYDYDEQNRKMVLGKGTYGTVYAARDKQTQVRI 611
            |      ||:.:|    ...::|.     :|::|:|.|...::||||||||.|||.||:.|:|||
  Rat   617 I------QVLVMNPDSSAPTEEAEGTREVLEFDYEYSETGERLVLGKGTYGVVYAGRDRHTRVRI 675

  Fly   612 AIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWG 676
            ||||:||::|:..|||||||.||.:|||:||||||||.|:.|:.|||||:|||||||.||.:.||
  Rat   676 AIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGSLSSLLRSVWG 740

  Fly   677 PLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMT 741
            ||||||||::||::|||:||.||||..||||||||||||:||:||::||||||||||||.|.|.|
  Rat   741 PLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPCT 805

  Fly   742 ETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHP 806
            |||||||||||||:||||.||||.||||||.|||.:|||||.|||.||||..||||:||.||.||
  Rat   806 ETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGWPPFHELGSPQAAMFQVGMYKVHP 870

  Fly   807 NIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRKVRPALPINTE----FGRSISVP 867
            .:|..|||.|:.|:||.|......|.||.:||.|||||...|...|..|.:|.    ...|.|.|
  Rat   871 PVPSSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTPRPSGTPSSTSSP 935

  Fly   868 -ADRFVHKTTPPLSYNTTCNTPTTPELDITHSSSVDIDELPSNQFMLERRNSHGFLLSPEIEPST 931
             ||......|.|.....:.:.|:.|:..:::..:..: .:|..              |...||::
  Rat   936 SADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQL-RVPEE--------------SAAEEPAS 985

  Fly   932 PSLRTSISETSETDGFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVL 996
            |         .|:.|...|.::|:||..|:.||   |.::..:....:|.:|:| .:.::.:|:|
  Rat   986 P---------EESSGLSLLHQESKRRAMLAAVL---EQEVPILAENLLDQEQDS-RLSRNHVELL 1037

  Fly   997 IRGLRDYIMNENEKHLEATINELKQKLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFAL 1061
            :|.|...|...|.:.|...:..|:.:|...:::...|...|::|.|||..:||...|:|||||.|
  Rat  1038 LRCLGAQIHTPNRRQLAQELRALQAQLRAQSLSPALLKGPLFAFPDAVKQILRRRQIRPHWMFVL 1102

  Fly  1062 DNLVKRAVQAAVTIFSPELGANLADKDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTRE 1126
            |:|:.|||:||:.:    |.|....|.:|...:|..:....|| ..|||  ..|:..||......
  Rat  1103 DSLLSRAVRAALAV----LDAEAEKKAVSPKSEEWSQGESQQK-PLESQ--PPLQSQLPPEQEPP 1160

  Fly  1127 G----VGLTPAESGGDALSSSMECARILRDIRDNQQKLQRQLLEQQRQSMRALHNISQELAHIYM 1187
            .    :||..||:..            ||||...:::..:.|::|      |||.:..|.
  Rat  1161 SLMIQLGLLRAETDR------------LRDILAEKERECQALVQQ------ALHRVHAET----- 1202

  Fly  1188 GGRKRLRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEI 1252
                              |.......|....|.                   |::|.|||....:
  Rat  1203 ------------------RTYALASETPATLPK-------------------DQKLVQWLQDLSV 1230

  Fly  1253 DEFSKTLILNEGFTF---------DDFIY 1272
            |..:...:|:..||.         ||.:|
  Rat  1231 DPTTIQTLLSHSFTLQTLLTCATQDDLVY 1259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020	139/381 (36%)
		STKc_ASK	576..843	CDD:270794	184/266 (69%)
		S_TKc	590..843	CDD:214567	180/252 (71%)
Map3k6	XP_006239081.1	DUF4071	130..507	CDD:290020	139/381 (36%)
		STKc_ASK	640..907	CDD:270794	184/266 (69%)
		S_TKc	654..907	CDD:214567	180/252 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351740
Domainoid	1	1.000	385	1.000	Domainoid score	I775
eggNOG	1	0.900	-	-		E1_KOG4279
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	908	1.000	Inparanoid score	I351
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D122434at33208
OrthoFinder	1	1.000	-	-		FOG0001687
OrthoInspector	1	1.000	-	-		otm44515
orthoMCL	1	0.900	-	-		OOG6_104013
Panther	1	1.100	-	-	O	PTHR11584
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1591
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760