DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ask1 and Map3k1

DIOPT Version :9

Sequence 1:	NP_477089.3	Gene:	Ask1 / 42366	FlyBaseID:	FBgn0014006	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	NP_036075.2	Gene:	Map3k1 / 26401	MGIID:	1346872	Length:	1493	Species:	Mus musculus

Alignment Length:	265	Identity:	101/265 - (38%)
Similarity:	153/265 - (57%)	Gaps:	21/265 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 LGKGTYGTVYAARDKQTQVRIAIKEV------PEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSC 649
            :|.|.:.:.|.|:|..|...:|:|:|      ..:..:.|:.|.|||::...|.|.||:|.||:.
Mouse  1230 IGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMGHLNHPNIIRMLGAT 1294

  Fly   650 SENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNV 714
            .|...:.:|:|.:.|||::.|| :|:|..|  ||.:..|::|:|.||.||||..|:|||:||.|:
Mouse  1295 CEKSNYNLFIEWMAGGSVAHLL-SKYGAFK--ESVVINYTEQLLRGLSYLHENQIIHRDVKGANL 1356

  Fly   715 LVNTYSGVVKISDFGTSKRLARINPMTETF----TGTLQYMAPEVIDQGVRG--YGPAADIWSFG 773
            |:::....::|:|||.:.|||........|    .||:.:|||||:    ||  ||.:.|:||.|
Mouse  1357 LIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVL----RGQQYGRSCDVWSVG 1417

  Fly   774 CTNVEMATGKPPF-IELGSAHAAM-FKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQ 836
            |..:|||..|||: .|..|.|.|: ||:......|:||..||...::..|||..:...|||.:.:
Mouse  1418 CAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRE 1482

  Fly   837 LLEDP 841
            ||:.|
Mouse  1483 LLKHP 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020
		STKc_ASK	576..843	CDD:270794	101/265 (38%)
		S_TKc	590..843	CDD:214567	101/265 (38%)
Map3k1	NP_036075.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..178
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..531
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..914
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	992..1066
		STKc_MEKK1	1223..1490	CDD:270800	101/265 (38%)
		S_TKc	1224..1489	CDD:214567	101/265 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910