DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ask1 and cdc7

DIOPT Version :9

Sequence 1:	NP_477089.3	Gene:	Ask1 / 42366	FlyBaseID:	FBgn0014006	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	NP_596340.1	Gene:	cdc7 / 2540660	PomBaseID:	SPBC21.06c	Length:	1062	Species:	Schizosaccharomyces pombe

Alignment Length:	823	Identity:	200/823 - (24%)
Similarity:	317/823 - (38%)	Gaps:	247/823 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 LGKGTYGTVYAARDKQTQVRIAIKEV--PEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENG 653
            ||||.:|.||...:.:....:|:|:|  .:....|:..:..||.|...|.|.|||:|.||...|.
pombe    15 LGKGAFGAVYRGLNIKNGETVAVKKVKLSKMLKSDLSVIKMEIDLLKNLDHPNIVKYRGSYQTND 79

  Fly   654 FFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNT 718
            ...|.:|....|||..:.: .:|.:.:|  .:|.|:.|:|:||.|||.|.::||||||.|:| .|
pombe    80 SLCIILEYCENGSLRSICK-NFGKIPEN--LVALYTFQVLQGLLYLHNQGVIHRDIKGANIL-TT 140

  Fly   719 YSGVVKISDFGTSKRLARINPMTE-TFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATG 782
            ..|.:|::|||.:   .:||.:.: :..|:..:||||||:  :.|...|:||||.|||.:|:..|
pombe   141 KDGTIKLADFGVA---TKINALEDHSVVGSPYWMAPEVIE--LVGATTASDIWSVGCTVIELLDG 200

  Fly   783 KPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKP 847
            .||:.:|... :|:|:: ...:||.:|..:|:.||:|:::||.             :||.|:.|.
pombe   201 NPPYYDLDPT-SALFRM-VKDEHPPLPSNISSAAKSFLMQCFQ-------------KDPNLRIKT 250

  Fly   848 RKV--RPALPIN---TEFGRSISVPADRF---VHKTTPPLSYNTTCN---------------TPT 889
            ||:  .|.:.:|   ::|..:|. ...::   |.::|.......|.|               .|.
pombe   251 RKLLKHPWVIMNQTSSKFSDAID-EVQKYNERVKESTLTAIIEPTSNRINPTLHSGRQSSYHMPE 314

  Fly   890 TPELDITHSS-------------SVDIDELPSNQFMLE-------RRNSHGFLLSP--------- 925
            :|:..|..|.             .:..|.|..::..::       :.||.....||
pombe   315 SPKTPIAESPDHDNWDNEFQGTLKISDDVLKKSEHFMDFCSNFKGKNNSSSITSSPSKSRHAFNS 379

  Fly   926 --------------------EIEPSTPSLRTSI-------------SETSET--DG---FYRLKK 952
                                :.:||.|:|..||             :|..|.  ||   |....:
pombe   380 DQISESNNFNASPLSTPLKAQFDPSKPALNRSIDHQKTPQHKRYLSTEFKENIPDGIEKFVETPR 444

  Fly   953 DSQ---------------RRTTLSKVLAL---------------DESKICD---IWLKKVDADQN 984
            ||:               |:.|....|.|               :||.|.|   ..|:.:|. :|
pombe   445 DSEFTDIFPTSSIKVQGLRKETGLGTLVLNKCYGSWNNEENEDGEESDIFDSIETNLENLDI-EN 508

  Fly   985 SIAIRK-----SDLEVLIRGLRD--------------YIMNEN--------EKH----LEATINE 1018
            :||:.|     |.|..|:..|||              .|::|:        :.|    |..|:.|
pombe   509 NIALDKRTHLASLLSSLLGSLRDKNIGSKDTTVSQIASILSEDLSLKREIIQAHGILPLLETLRE 573

  Fly  1019 LKQ--------KLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLV-----KRAVQ 1070
            :|.        ||.|.....||..|....|...:..:|.:...:..:.|..::.:     .|...
pombe   574 IKTPDVQLLLLKLINTVAFDDHTTLQKVCFAGGLPLMLSFSNREHSFEFRYESAIFIQQMYRTSA 638

  Fly  1071 AAVTIFSPELGAN----LADKDLSGNDD------ESLRTSLMQKGSTESQE------KQSLE--- 1116
            ..:.:|....|.|    ...:|...|.|      |.:...|.|:......:      ..|||
pombe   639 LTLQMFLSSNGLNSLLLFIKEDYGTNRDFVFVGVEGIWKLLRQQDYIPKNDICTMVVNDSLEPLT 703

  Fly  1117 ----KVLPTSNTREGVGLT-------PAESGGDALSSSMECARILRDI---------RDNQQKLQ 1161
                |.|.|.:....:.||       ......:.:..|:.|...||.|         .|....||
pombe   704 KAMLKALATDDDSSRMSLTRICEILLALSQADNYVKESLLCESALRRILRILLYLPHSDMAITLQ 768

  Fly  1162 --RQL--LEQQRQSMRALHNISQELAHIYMG------GRKRLR 1194
              :||  :......:|.:| |...|.|| :|      |||.:|
pombe   769 FFKQLSMVPSSLSLLRKVH-IIPLLTHI-LGDSKIEKGRKEIR 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020
		STKc_ASK	576..843	CDD:270794	90/254 (35%)
		S_TKc	590..843	CDD:214567	90/254 (35%)
cdc7	NP_596340.1	STKc_Cdc7_like	10..259	CDD:270797	95/267 (36%)
cdc7	NP_596340.1	S_TKc	10..259	CDD:214567	95/267 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6807
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940