Protein Alignment Ask1 and si:ch211-1i11.3

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: XP_009290786.1
• Gene: si:ch211-1i11.3 / 100005496
• ZFINID: ZDB-GENE-030131-8638
• Length: 1324
• Species: Danio rerio
• Alignment Length: 1323
• Identity: 524/1323 - (39%)
• Similarity: 754/1323 - (56%)
• Gaps: 100/1323 - (7%)

  Fly    21 ALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFG 85
            :|:.:.:|...|.|..:.:.:||:..|.|.:|:|||||||.:::::....|..|.||.||||||.
Zfish    73 SLKCLTEACADAHAVLKSISYERIALGTTEILDTFYNADVVVVEMNNSICQPSLFYHLGVRESFS 137

  Fly    86 MKENILTYNDIDSKQTLSLKLSCANYLFLSYKRNAE-----TNSCHLTSQPNSGNNSKEPNAEGR 145
            |..|::.|.:........:|..|.:|.|:.|..:.:     .::..:.:..:..::|.:  .|..
Zfish   138 MTNNVILYCNKQEDDMQVVKEQCGSYTFIPYMVSPQGKVFACDAALMRAVKDFLHSSFK--FESL 200

  Fly   146 VPTLQWRLKRKLQDVEIQSKAHMREKFLSDMRTARDTYATNGAKLQSILHEMRKRLDDPHVLSGE 210
            :.:|..||.:.|:.|.|.|..::.|....::|.||:.:  .|..|...|..::||||...:||.:
Zfish   201 MTSLVDRLVKLLESVHINSSEYLHEAIRREIRLAREHF--TGPALSQELGRIQKRLDSVELLSPD 263

  Fly   211 VVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSL 275
            :|.|.:.|.||:.|||:::.||..|.|:|........ |:.|.|.|||||||..|||.:||:..|
Zfish   264 IVMSLLLSYRDIPDYDSIINLVETLNNLPMCMVPAHQ-NIKFQYIFALNRRNHPGDRVRALKLIL 327

  Fly   276 KALEKKENHFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVI 340
            ..:|..|....|:.|||||||||:|:.|.:.|..|...|.|||.::|.::|:.::|||...||:.
Zfish   328 PIVESGETVASDVYCLCGRIYKDMFLSSGFKDTNSRDQASKWYGKAFTIEPSLHSGINNVVLLMA 392

  Fly   341 EGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKLKP 405
            .|.||..:.||:.||:||::|:|:||||..:.:||||..:....:|||::.|.|.|:|.:::||.
Zfish   393 AGHEFDTSIELRKIGVTLSSLLGRKGSLEKMQDYWDVGFYLGAGILANEHKKVIDASERLYRLKA 457

  Fly   406 PNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNTEEVKNSIRFPILILEPQK 470
            |.||:.|.:....|..:|.|..|...|  :::...|||:..::|  .:...::.|.|:|||||.|
Zfish   458 PMWYVASIMETYILYKQFAKPREVNHP--KQETADFWMELMVQA--CKPTVSTARCPVLILEPTK 518

  Fly   471 IYMPSYVTINMDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHN 535
            ::.||.::::.:.|.:::|     |.|.....|.:|::.|.||.|:.||:.|.|:|..:|||.:|
Zfish   519 VFQPSIISVSEEDDSRTVQ-----LRHVTPLEKGLHEWTFPASAIRGVSISKFDERSCFLYVLYN 578

  Fly   536 SDDFQIYFPSTERRQKFYDMI---LEMTADQVV-FVNLSNDDANIEYEYDYDEQNRKMVLGKGTY 596
            |||||:||||....:.|.|::   |..|...|. ..::..::.::||.|:.:|...|:|||||||
Zfish   579 SDDFQLYFPSDLHCKGFCDLVNSLLHQTESPVEDSSSMRGEEGDLEYIYERNENGDKVVLGKGTY 643

  Fly   597 GTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQ 661
            |.|||.||...||||||||:|||:|...|||||||.||.:|:|||||:||||.||:||.|||||:
Zfish   644 GVVYAGRDLSNQVRIAIKEIPEKDSTYSQPLHEEIALHKRLKHRNIVQYLGSVSEDGFIKIFMEE 708

  Fly   662 VPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKIS 726
            |||||||.||.:|||||||||:|:.||:||||:||||||:..|||||||||||||||||||:|||
Zfish   709 VPGGSLSSLLRSKWGPLKDNEATIVFYTKQILDGLKYLHDNQIVHRDIKGDNVLVNTYSGVLKIS 773

  Fly   727 DFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGS 791
            |||||||||.|||.||||||||||||||:||||.||||..|||||.|||.:|||||||||.||||
Zfish   774 DFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGKPADIWSLGCTIIEMATGKPPFHELGS 838

  Fly   792 AHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRKVRPALPI 856
            ..|||||||.:|.||.:||.:|..||:||:.||..:...|.:||:||::.||:...:|....|..
Zfish   839 PQAAMFKVGMFKIHPAVPECMSEQAKDFIMCCFEPNPDKRTTASELLKNGFLKASAKKRLKPLAD 903

  Fly   857 NT------EFGRSISVPADRFVHKTTPPLSYNTTCNTPTTPELDITH---SSSVDIDELPS---- 908
            |:      ||.||:|||....|..|                  |:.|   |.|.|:....|
Zfish   904 NSLKEPAGEFHRSMSVPVALRVENT------------------DVEHNELSCSFDLRRATSAFKG 950

  Fly   909 NQFMLERRNSHGFLLSPEIEPSTPSLRTSISETSETDGFYRLKKDSQRRTTLSKVLALDESKICD 973
            |.......::.|||..|: ||.. .:.||.|.:.|..|.:.|:|||:||.||.::|..|.|.:..
Zfish   951 NNMAESPPSTSGFLTVPD-EPQI-DMTTSPSGSGENLGLFMLRKDSERRDTLHRILTEDISHVVQ 1013

  Fly   974 IWLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQKLNNDAVALDHLHLALY 1038
            . :::.........|....:..||..||:.|.:.:::.|..::..|:..|.|.:|.|..|...|:
Zfish  1014 N-IQETMPQAEEPCITSDHISELIGCLRENIRSPDKRLLTNSLLTLRSSLLNSSVPLSSLQAVLF 1077

  Fly  1039 SFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPELGANLADKDLSGNDDESLRTSLMQ 1103
            ||||||..|||...||||||||||||:::|||.|:|:..|||...|.    |..::|
Zfish  1078 SFQDAVKKVLRKQQIKPHWMFALDNLLRQAVQDAITVLLPELKLQLQ----SSFENE-------- 1130

  Fly  1104 KGSTESQ---EKQSLEKVLPTSNTREGVGLTPAESGGDALSSSMECARILRDIRDNQQKLQRQLL 1165
            :||.|::   |..|...|.|.:..:|.:.:|.....|.:..:|:..|.|     .:...|.::|.
Zfish  1131 EGSPETEHPTEADSESIVTPLAKDKETLVITKDPEEGHSTCNSLPTALI-----SSYSSLAKELS 1190

  Fly  1166 EQQRQSMRALHNISQ---ELAHIYMGGRKRLRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRR 1227
            |.:.:|.|.|..:::   |...:.....:..:|.||....|....:|....||....|.|
Zfish  1191 ELRLESRRLLMQLNEKEKEFQQLLKTSLQSKQRHINALEHKAASAATDNKQTSHNAQNSA----- 1250

  Fly  1228 QLNKHHFGLHEVDEQLEQWLTQQEIDEFSKTLILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRL 1292
                           :.:||....:||.:..|::...||.|..::...|.||...|::.|:..||
Zfish  1251 ---------------MVRWLRGVPVDEKTIELLVFHEFTLDSLLHFACKDDLQYCGIKGGMMCRL 1300

  Fly  1293 WKLIIQERVCTSSDCVDSPPSTY 1315
            |..|.::|....|...:....|:
Zfish  1301 WAAISKQRKSHLSPVKEDSEDTF 1323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459	12/34 (35%)
		MAP3K_TRAF_bd	74..445	CDD:463827	135/375 (36%)
		ASK_PH	457..560	CDD:465956	41/105 (39%)
		STKc_ASK	576..843	CDD:270794	190/266 (71%)
		HisK-N-like	948..1079	CDD:466452	51/130 (39%)
si:ch211-1i11.3	XP_009290786.1	MAP3K_TRAF_bd	126..494	CDD:463827	134/374 (36%)
		ASK_PH	505..603	CDD:465956	40/102 (39%)
		STKc_ASK	623..890	CDD:270794	190/266 (71%)
		HisK-N-like	988..1118	CDD:466452	51/130 (39%)