DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and yejF

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_416685.1	Gene:	yejF / 946689	ECOCYCID:	EG12041	Length:	529	Species:	Escherichia coli

Alignment Length:	282	Identity:	71/282 - (25%)
Similarity:	133/282 - (47%)	Gaps:	50/282 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1053 EPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKY-FP------DKAADY--VLRSLNIAIEGCEKV 1108
            ||.||         |...||....:.|...|:. ||      .:..|:  |:::::..:...|.:
E. coli   260 EPSGD---------PVPLPEPASTLLDVEQLQVAFPIRKGILKRIVDHNVVVKNISFTLRAGETL 315

  Fly  1109 GIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLG---LHDLRSKISIIPQEPVLFSGTMRY 1170
            |:||.:|:|||:...||.||..::|:|:.|.:...:|.   |..:|.:|.::.|:|       ..
E. coli   316 GLVGESGSGKSTTGLALLRLINSQGSIIFDGQPLQNLNRRQLLPIRHRIQVVFQDP-------NS 373

  Fly  1171 NLDPFDEYSDAKLWESLEE------------VKLKQVVADLPS-GLQSKISEG-GTNFSVGQRQL 1221
            :|:|     ...:.:.:||            .:.:||:|.:.. ||..:.... ...||.||||.
E. coli   374 SLNP-----RLNVLQIIEEGLRVHQPTLSAAQREQQVIAVMHEVGLDPETRHRYPAEFSGGQRQR 433

  Fly  1222 VCLARAILRENRILVMDEATANVDPQTDALIQTTIRN--KFKDCTVLTIAHRLHTVMD-SDKVLV 1283
            :.:|||::.:..::::||.|:::|....|.|.|.:::  :......|.|:|.||.|.. ..:|::
E. coli   434 IAIARALILKPSLIILDEPTSSLDKTVQAQILTLLKSLQQKHQLAYLFISHDLHVVRALCHQVII 498

  Fly  1284 MDAGKAVEFGSPFELLTTSEKK 1305
            :..|:.||.|....:..|.:::
E. coli   499 LRQGEVVEQGPCARVFATPQQE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	70/275 (25%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371
		ABCC_MRP_domain2	1074..1295	CDD:213211	63/249 (25%)
yejF	NP_416685.1	PRK15134	1..529	CDD:237917	71/282 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
	2	2.050