DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and ABCC10

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:XP_016866934.1 Gene:ABCC10 / 89845 HGNCID:52 Length:1558 Species:Homo sapiens


Alignment Length:1390 Identity:440/1390 - (31%)
Similarity:700/1390 - (50%) Gaps:167/1390 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDE-NDLYRALQEHRSDHLGSKLSAAWEKEVE 70
            |:.||...:..:..|...:.:..|...:|....|.: .|:.|.....:..:|.....|.|::...
Human   259 DQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGAR 323

  Fly    71 KKRKKKKTPSLLKASMNVFGWRLAGLGLVLFI-LEIGFRVTQPLFLGGLVAYYADASNQEGDNQ- 133
                      |.:|....||.....|||:..: ..:||  :.||.|..||.:.     :||... 
Human   324 ----------LWRALYGAFGRCYLALGLLKLVGTMLGF--SGPLLLSLLVGFL-----EEGQEPL 371

  Fly   134 TKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
            :...|||||:...:....:..:.|...::.:.::||.|:.:::|.|||:|..:.   ...|:.:|
Human   372 SHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTGEALN 433

  Fly   199 LISNDVGRLDVSVIHMNY------LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLG 257
            |:..|..||      :|:      .|..|:::.|..||:|:::|::...|:.:.||.:|:...:.
Human   434 LLGTDSERL------LNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIA 492

  Fly   258 KKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT- 321
            .:......:.....|.||:::.|::|||:|||...||......:...|.:|:..:|.:.|:... 
Human   493 TRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAAC 557

  Fly   322 --LQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVS 384
              |.:.:..|..|.:|::   :||:|..|||.|.|...|...:|...:. .||..|:...|..||
Human   558 VYLWAALPVVISIVIFIT---YVLMGHQLTATKVFTALALVRMLILPLN-NFPWVINGLLEAKVS 618

  Fly   385 IRRIQTFMLHEETKVRDKSEDLDEQK--------LGKAG------LIAEPTVAQTTGVLKPSSRR 435
            :.|||.|:            ||....        .|:.|      |.::|          |:...
Human   619 LDRIQLFL------------DLPNHNPQAYYSPDCGRLGAQIKWLLCSDP----------PAEPS 661

  Fly   436 TSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSG 500
            |....|..:.|     ||...|........|:.|...||.::|.||.|||||:.|:.|||:...|
Human   662 TVLELHGALFS-----WDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRG 721

  Fly   501 SVKVNGT---LSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVG 562
            .|.|.|.   ...|:||||:...|:|.|||||...|...|:.|::.|||..|..:||..|:|.||
Human   722 HVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVG 786

  Fly   563 ERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQL 627
            |:|.:|||||:|||:||||||::.::|||||||:|||..|..||..:|:.|.|.....||.||:.
Human   787 EKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRT 851

  Fly   628 QFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRD 692
            ::||:||.:::|:.|::...|....:    |...|.:  |....|...::....:.|.||.:   
Human   852 EYLERADAVLLMEAGRLIRAGPPSEI----LPLVQAV--PKAWAENGQESDSATAQSVQNPE--- 907

  Fly   693 RHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASG 757
                 .:.|...|..:....:..:|.:.||.:.:.:|:.|:.|.|.||.:...|..:..|...:.
Human   908 -----KTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNA 967

  Fly   758 GDIFLSYWV------NKNGEAERDTFMARLRRAFPETRINADTD---PV------------DI-Y 800
            .|.:||:|:      |.:.||:..|..|.:....|:..:.:..:   ||            || :
Human   968 ADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRF 1032

  Fly   801 YFT------GINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRF 859
            |.|      |:|   .:.:|:|::||....::::.|||..:...|..|.:.|||..|:|||||||
Human  1033 YLTVYATIAGVN---SLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRF 1094

  Fly   860 SKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVK 924
            |.|:...|:.||.::..::.....::|::.||.....|.:|....|.|::|.::..|.::||:::
Human  1095 SSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELR 1159

  Fly   925 RLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-- 987
            ||.::|.||:||||:.:|.||:.:||.||....  |.:|.:.:..:....| ||| |...|||  
Human  1160 RLGSLTLSPLYSHLADTLAGLSVLRATGATYRF--EEENLRLLELNQRCQF-ATS-ATMQWLDIR 1220

  Fly   988 -----CVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVV 1047
                 ...|..||.|.|........|.|.|||:::.|:.:||::...:....:.|..:.:|||:.
Human  1221 LQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLE 1285

  Fly  1048 EYEDLEPEGDFESKPNKKPPK---DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVG 1109
            ||     ..|...:|..:|.:   .|...|.:.|.|:.|.|.|  .....|..:...::..||:|
Human  1286 EY-----TCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRP--GLPNALDGVTFCVQPGEKLG 1343

  Fly  1110 IVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLD 1173
            ||||||:|||||:..||| |..:.|.:|:|..||:.|.|..|||:::||||||.|||||:|.|||
Human  1344 IVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLD 1408

  Fly  1174 PFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMD 1238
            |...:.|..||::|::..|.:|:..: .||..::.|||.:.|:|||||:|||||:|.:.:||.:|
Human  1409 PQGLHKDRALWQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCID 1472

  Fly  1239 EATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSE 1303
            ||||:||.:||.|:|.||..:|.:.|||||||||:|:::||:|||:.||:.||..||        
Human  1473 EATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP-------- 1529

  Fly  1304 KKVFHSMVKQTGDSTFDALLKVAQK 1328
                 :.::....|.|..||:.:|:
Human  1530 -----ATLRNQPHSLFQQLLQSSQQ 1549

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 432/1355 (32%)
ABC_membrane 98..367 CDD:294371 72/279 (26%)
ABCC_MRP_domain1 443..643 CDD:213217 90/202 (45%)
ABC_membrane 799..1027 CDD:294371 80/241 (33%)
ABCC_MRP_domain2 1074..1295 CDD:213211 109/221 (49%)
ABCC10XP_016866934.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151622
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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