Protein Alignment Mrp5 and ABCC10

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_054212675.1
• Gene: ABCC10 / 89845
• HGNCID: 52
• Length: 1543
• Species: Homo sapiens
• Alignment Length: 1380
• Identity: 440/1380 - (31%)
• Similarity: 697/1380 - (50%)
• Gaps: 162/1380 - (11%)

  Fly     7 DELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDE-NDLYRALQEHRSDHLGSKLSAAWEKEVE 70
            |:.||...:..:..|...:.:..|...:|....|.: .|:.|.....:..:|.....|.|::...
Human   259 DQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGAR 323

  Fly    71 KKRKKKKTPSLLKASMNVFGWRLAGLGLVLFI-LEIGFRVTQPLFLGGLVAYYADASNQEGDNQ- 133
                      |.:|....||.....|||:..: ..:||  :.||.|..||.:.     :||...
Human   324 ----------LWRALYGAFGRCYLALGLLKLVGTMLGF--SGPLLLSLLVGFL-----EEGQEPL 371

  Fly   134 TKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
            :...|||||:...:....:..:.|...::.:.::||.|:.:::|.|||:|..:.   ...|:.:|
Human   372 SHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSR---PPTGEALN 433

  Fly   199 LISNDVGRLDVSVIHMNY------LWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLG 257
            |:..|..||      :|:      .|..|:::.|..||:|:::|::...|:.:.||.:|:...:.
Human   434 LLGTDSERL------LNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIA 492

  Fly   258 KKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT- 321
            .:......:.....|.||:::.|::|||:|||...||......:...|.:|:..:|.:.|:...
Human   493 TRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAAC 557

  Fly   322 --LQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVS 384
              |.:.:..|..|.:|::   :||:|..|||.|.|...|...:|...:. .||..|:...|..||
Human   558 VYLWAALPVVISIVIFIT---YVLMGHQLTATKVFTALALVRMLILPLN-NFPWVINGLLEAKVS 618

  Fly   385 IRRIQTFMLHEETKVRDKSEDL---DEQKLGKAGLIAEP-TVAQTTGVLKPSSRRTSEAEHSIVI 445
            :.|||.|:            ||   :.|........||| ||.:..|.|
Human   619 LDRIQLFL------------DLPNHNPQAYYSPDPPAEPSTVLELHGAL---------------- 655

  Fly   446 SKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT--- 507
                ..||...|........|:.|...||.::|.||.|||||:.|:.|||:...|.|.|.|.
Human   656 ----FSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKG 716

  Fly   508 LSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQ 572
            ...|:||||:...|:|.|||||...|...|:.|::.|||..|..:||..|:|.|||:|.:|||||
Human   717 FGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQ 781

  Fly   573 KARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIV 637
            :|||:||||||::.::|||||||:|||..|..||..:|:.|.|.....||.||:.::||:||.::
Human   782 RARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVL 846

  Fly   638 IMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMES 702
            :|:.|::...|....:    |...|.:  |....|...::....:.|.||.:        .:.|.
Human   847 LMEAGRLIRAGPPSEI----LPLVQAV--PKAWAENGQESDSATAQSVQNPE--------KTKEG 897

  Fly   703 AAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWV- 766
            ..|..:....:..:|.:.||.:.:.:|:.|:.|.|.||.:...|..:..|...:..|.:||:|:
Human   898 LEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWIS 962

  Fly   767 -----NKNGEAERDTFMARLRRAFPETRINADTD---PV------------DI-YYFT------G 804
                 |.:.||:..|..|.:....|:..:.:..:   ||            || :|.|      |
Human   963 QLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAG 1027

  Fly   805 INVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEI 869
            :|   .:.:|:|::||....::::.|||..:...|..|.:.|||..|:||||||||.|:...|:.
Human  1028 VN---SLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDS 1089

  Fly   870 LPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPI 934
            ||.::..::.....::|::.||.....|.:|....|.|::|.::..|.::||:::||.::|.||:
Human  1090 LPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPL 1154

  Fly   935 YSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-------CVCVV 992
            ||||:.:|.||:.:||.||....  |.:|.:.:..:....| ||| |...|||       ...|.
Human  1155 YSHLADTLAGLSVLRATGATYRF--EEENLRLLELNQRCQF-ATS-ATMQWLDIRLQLMGAAVVS 1215

  Fly   993 YIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGD 1057
            .||.|.|........|.|.|||:::.|:.:||::...:....:.|..:.:|||:.||     ..|
Human  1216 AIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEY-----TCD 1275

  Fly  1058 FESKPNKKPPK---DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKS 1119
            ...:|..:|.:   .|...|.:.|.|:.|.|.|  .....|..:...::..||:|||||||:|||
Human  1276 LPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRP--GLPNALDGVTFCVQPGEKLGIVGRTGSGKS 1338

  Fly  1120 SLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKL 1183
            ||:..||| |..:.|.:|:|..||:.|.|..|||:::||||||.|||||:|.||||...:.|..|
Human  1339 SLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRAL 1403

  Fly  1184 WESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQT 1248
            |::|::..|.:|:..: .||..::.|||.:.|:|||||:|||||:|.:.:||.:|||||:||.:|
Human  1404 WQALKQCHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKT 1467

  Fly  1249 DALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQ 1313
            |.|:|.||..:|.:.|||||||||:|:::||:|||:.||:.||..||             :.::.
Human  1468 DQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSP-------------ATLRN 1519

  Fly  1314 TGDSTFDALLKVAQK 1328
            ...|.|..||:.:|:
Human  1520 QPHSLFQQLLQSSQQ 1534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	423/1292 (33%)
ABCC10	XP_054212675.1	MRP_assoc_pro	<324..1520	CDD:188098	423/1289 (33%)