DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC3

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_003777.2	Gene:	ABCC3 / 8714	HGNCID:	54	Length:	1527	Species:	Homo sapiens

Alignment Length:	1394	Identity:	478/1394 - (34%)
Similarity:	733/1394 - (52%)	Gaps:	167/1394 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKK----- 72
            |...:...|.|.|.:.......|.:..|:|.||:...:|.||..:..:|..||.|: ||:
Human   208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQ-EKQTARHK 271

  Fly    73 -------------------RKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ------- 111
                               |.:.:.||.|||.:..||        ..|::...|::.|
Human   272 ASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFG--------SSFLISACFKLIQDLLSFIN 328

  Fly   112 PLFLGGLVAYYAD--ASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTS 174
            |..|..|:.:.::  |.:..|      :|.|..:.|.|....|.:..|...:|..|:|.|..:..
Human   329 PQLLSILIRFISNPMAPSWWG------FLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMG 387

  Fly   175 MIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISA 239
            :||||||.::.:....:|:|::|||:|.|..|.......:|.||..|::|.:..|.:::.:|.|.
Human   388 VIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLWQNLGPSV 452

  Fly   240 FFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYV 304
            ..|||.|:|.|||...:..|....::|.....|.|:::|:||::||:|:|:||||..|.|.:..:
Human   453 LAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPSFLKQVEGI 517

  Fly   305 RTKEMNAIRNVNYIRGTLQSFIM----FVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRN 365
            |..|:..:|...|:..|.....|    .||.|:::|.:  :|....:|.||||||..:.:||||.
Human   518 RQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYV--YVDPNNVLDAEKAFVSVSLFNILRL 580

  Fly   366 TMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLK 430
            .:.: .|..||...:..||::|||.|:..||         ||.|.:
Human   581 PLNM-LPQLISNLTQASVSLKRIQQFLSQEE---------LDPQSV------------------- 616

  Fly   431 PSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGEL 495
              .|:|....::|.|......|.| :...||.::.::.....||||:||||.|||||:.|:|||:
Human   617 --ERKTISPGYAITIHSGTFTWAQ-DLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEM 678

  Fly   496 NPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTI 560
            ....|.|.:.|:::|..|:.|:...|:::|:|||..::..||:..::.|||..|.|:||..|:|.
Human   679 EKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALLADLEMLPGGDQTE 743

  Fly   561 VGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLV 623
            :||:|.:|||||:.|:|||||||..|||:||||||||||:||.:|:||..:  .|.|..:..:||
Human   744 IGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLV 808

  Fly   624 THQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAG----------DAP 678
            ||.:.||.|.|.|:::..|::|.||.|.::.:....||..|.:.: .||..|          .|.
Human   809 THGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYA-PDEDQGHLEDSWTALEGAE 872

  Fly   679 DKKSL--------------------------SRQNSKLRD-----------RHGSISSMESAAES 706
            ||::|                          .||.|.|..           ||...|......|:
Human   873 DKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPSEKVQVTEA 937

  Fly   707 LAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGE 771
             .|:..:..:|....|.:.:.::..|..|.|....:......:|....|.|.:::||.|.|.
Human   938 -KADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGANVWLSAWTND--- 998

  Fly   772 AERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMF 836
                        |..::|.|..:..:.:|...||....::  ::.:|......::::..||..:.
Human   999 ------------AMADSRQNNTSLRLGVYAALGILQGFLV--MLAAMAMAAGGIQAARVLHQALL 1049

  Fly   837 QGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILA 901
            ....|:...||:|.|||||||.||||:..|||:|..|::.::..|...:..:||:......:.:.
Human  1050 HNKIRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVV 1114

  Fly   902 TVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQD 966
            .:.|.:::.|::.||.:|||.:||||:|:|||||||.|.::.|.:.|||:...::.....|...|
Human  1115 ILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVD 1179

  Fly   967 MHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITLSFFLF--SPENGGDVGLAITQAMGMTGMVQ 1027
            .:....|.::.::|.....::.|  |||..|.:   |.:.  |..|.|.|||:::.::.:|..:.
Human  1180 ANQRSCYPYIISNRWLSIGVEFVGNCVVLFAAL---FAVIGRSSLNPGLVGLSVSYSLQVTFALN 1241

  Fly  1028 WGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAAD 1092
            |.:|..::||:.:.|||||.||...|.|..:..: ..:||:.||..|::.|.:.|::|.|  ..|
Human  1242 WMIRMMSDLESNIVAVERVKEYSKTETEAPWVVE-GSRPPEGWPPRGEVEFRNYSVRYRP--GLD 1303

  Fly  1093 YVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISI 1156
            .|||.|::.:.|.|||||||||||||||:...||| |...:|.|.||..:..|:|||||||:::|
Human  1304 LVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368

  Fly  1157 IPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQL 1221
            |||:|:|||||:|.|||||..||:..:|.:||...|...|:..|:||..:.||||.|.|||||||
Human  1369 IPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQL 1433

  Fly  1222 VCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDA 1286
            ||||||:||::||||:|||||.:|.:||.|||.|||.:|..||||||||||:|:||..:|||:|.
Human  1434 VCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDK 1498

  Fly  1287 GKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |...||.||..|:  :.:.:|:.|.:..|
Human  1499 GVVAEFDSPANLI--AARGIFYGMARDAG 1525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	475/1377 (34%)
		ABC_membrane	98..367	CDD:294371	87/281 (31%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/201 (45%)
		ABC_membrane	799..1027	CDD:294371	70/231 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	127/221 (57%)
ABCC3	NP_003777.2	SunT	7..1526	CDD:331423	478/1394 (34%)
ABCC3	NP_003777.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..932		4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151509
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660