DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and VMR1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_011828.1	Gene:	VMR1 / 856350	SGDID:	S000001027	Length:	1592	Species:	Saccharomyces cerevisiae

Alignment Length:	1458	Identity:	436/1458 - (29%)
Similarity:	725/1458 - (49%)	Gaps:	230/1458 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DELPENPREKSNIFSSLMFCFAMPTFFKGRKKT---LDENDLYRALQEHRS---DHLGSKLSA-- 63
            |::|      |.||  .:|.|.:.:..:..|.|   .|.:.:.....:|.|   :|:.|.||.
Yeast   223 DDVP------SQIF--YIFEFVITSTLQPIKLTSPIKDNSSIIYVRDDHTSPSREHISSILSCIT 279

  Fly    64 -------AWEKE---VEKK-------------------RKKKKTPSLLKASMNVF-GWRLAGLGL 98
                   .||.:   ::.|                   |:.|...:|..|....| .:.|.|:
Yeast   280 WSWITNFIWEAQKNTIKLKDIWGLSMEDYSIFILKGFTRRNKHINNLTLALFESFKTYLLIGM-- 342

  Fly    99 VLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVI---LTSA-CNVLFMHPYML 159
             |::|........|..|........|..|:.......|:||.:|:.   ||.| ||       ..
Yeast   343 -LWVLVNSIVNLLPTILMKRFLEIVDNPNRSSSCMNLAWLYIIGMFICRLTLAICN-------SQ 399

  Fly   160 GMF---HIGMKARIAMTSMIYRKALR----LSRTALGDT-----TIGQVVNLISNDVGRLDVSVI 212
            |.|   .|.::.|..:...||.|.||    .|.....|:     .:|.::||||.|  ...||.:
Yeast   400 GQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSDSISANLGTIINLISID--SFKVSEL 462

  Fly   213 HMNYLWL---GPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDER 274
             .|||::   ..:.|.::..|::..:|:|||.|::::|:..||...|.......:.:|...||:|
Yeast   463 -ANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVMFPLNFLLANLLGKFQKQTLKCTDQR 526

  Fly   275 VRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVSLV 339
            :..:||.:..|:::|.:|||......|..:|.||:.::...:.: .::.||:.|||  ...|:.|
Yeast   527 ISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSLV-WSVTSFLWFVT--PTLVTGV 588

  Fly   340 GFVLLGKL----LTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVR 400
            .|.:...:    |.|..||...:.:.:|:..:.....| :|...:..||::||..|:..::|:
Yeast   589 TFAICTFVQHEDLNAPLAFTTLSLFTLLKTPLDQLSNM-LSFINQSKVSLKRISDFLRMDDTE-- 650

  Fly   401 DKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNT---LD 462
                                         |.:....|..::.|........|::.::|..   |.
Yeast   651 -----------------------------KYNQLTISPDKNKIEFKNATLTWNENDSDMNAFKLC 686

  Fly   463 NISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKV----------------NGTLSYA 511
            .:::||:..:|..::|..|||||:|:..:|||||..|||:.|                ..:.:|.
Yeast   687 GLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYC 751

  Fly   512 SQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARI 576
            ||..||...||:.||:|....::.||..|:..|.|:||.|:||..|.|.:||:|.:||||||.||
Yeast   752 SQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRI 816

  Fly   577 SLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRG-FLREEIVLLVTHQLQF-LEQADVIVIM 639
            |||||||..|...||||.|||||:|....:::.|:.| .::....:||||.:.. |..|...:::
Yeast   817 SLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITGPLMKNRTCILVTHNVSLTLRNAHFAIVL 881

  Fly   640 DKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQN-SKLR-DRHGSISSMES 702
            :.||:...||...:...|| |.:.....|.:|          |::.:| ::|: .|......:|.
Yeast   882 ENGKVKNQGTITELQSKGL-FKEKYVQLSSRD----------SINEKNANRLKAPRKNDSQKIEP 935

  Fly   703 AAESL------AAESPMQTQEGRVEGRIGMKLYK---KYFGANGY-GLFIVFAFFCIGAQVLASG 757
            ..|::      ..:..:..:|.:..|.|...:||   |:||  |: .|..:||.: |.||:|...
Yeast   936 VTENINFDANFVNDGQLIEEEEKSNGAISPDVYKWYLKFFG--GFKALTALFALY-ITAQILFIS 997

  Fly   758 GDIFLSYWVNKNGEAERDTFMARLRRAFPETRINA-----DTDPVD------------IYYFTGI 805
            ...::.:|||       ||          ..||||     ||.|:.            .||.|..
Yeast   998 QSWWIRHWVN-------DT----------NVRINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVY 1045

  Fly   806 NVSVIIFSLV---RSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVD 867
            .:..||.:::   ::|:.|...||:|..:.|.:...|..|.:.||:..|.|||:||||||:..||
Yeast  1046 FLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVD 1110

  Fly   868 -EILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTR 931
             |::|.:.:.:. ..:....|:.::.:|...::...|.:.::::.:..:||:.||::|||:::|:
Yeast  1111 QELIPYLEVTIF-CLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITK 1174

  Fly   932 SPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAV 996
            |||:.|.|.:|.|:.||||||.::..|.|..|..|.::..::....|.:.|.:.:|.: ..:|.:
Yeast  1175 SPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMI-GAFIVL 1238

  Fly   997 ITLSFFLFSPEN--GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPE---G 1056
            .:.||.|.:..|  .|..|:::|.|:..|....|.:|..:..|..|.:|||:.||..:|.|   |
Yeast  1239 ASGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQENYLG 1303

  Fly  1057 DFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSL 1121
            ..|.:........||:||:|..::|||:|.|:...  |:|:::..::...|:|||||||||||::
Yeast  1304 HDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPP--VIRNVSFKVDPQSKIGIVGRTGAGKSTI 1366

  Fly  1122 INALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWE 1185
            |.|||| |....|.|.||.:|.:.:.|..||..|:||||:|:||:||::.|:||:|||.:.|:::
Yeast  1367 ITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFK 1431

  Fly  1186 SLEEVKL------KQVVADLPS---------GLQSKISEGGTNFSVGQRQLVCLARAILRENRIL 1235
            :|.:|.|      ::|:.....         .|.::|:|||.|.|.|:|||:.:||::|||.:|:
Yeast  1432 ALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKII 1496

  Fly  1236 VMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLT 1300
            ::||||:::|..:|.|||..||::|...|:|||||||.:|:|.|:::|||||:..|:..|.|||
Yeast  1497 LLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELL- 1560

  Fly  1301 TSEKKVFHSMVKQTGDSTFDALLKVAQK 1328
            ..|:.:|:||.:.:|.  .:.|.::|::
Yeast  1561 KDERGIFYSMCRDSGG--LELLKQIAKQ 1586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	426/1423 (30%)
		ABC_membrane	98..367	CDD:294371	76/291 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	82/220 (37%)
		ABC_membrane	799..1027	CDD:294371	70/233 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	102/236 (43%)
VMR1	NP_011828.1	MRP_assoc_pro	212..1575	CDD:188098	433/1443 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344644
Domainoid	1	1.000	64	1.000	Domainoid score	I2425
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640