DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and YKR104W

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_013030.1	Gene:	YKR104W / 853979	SGDID:	S000001812	Length:	306	Species:	Saccharomyces cerevisiae

Alignment Length:	310	Identity:	129/310 - (41%)
Similarity:	192/310 - (61%)	Gaps:	33/310 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  1040 MTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFP--DKAADYVLRSLNIAI 1102
            |::|||:.||.|:..    ||.....||.:||:.|.:...:|||:|.|  .||.|    :::..:
Yeast     1 MSSVERIKEYTDIPS----ESNGYISPPANWPQTGDVELKNLSLRYSPHSSKALD----NVSFKV 57

  Fly  1103 EGCEKVGIVGRTGAGKSSLINALFRLS-YNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSG 1166
            :...||||||||||||||:|.|::||| :..|.|.||.:|...:.|..||:.||.|||:|.||.|
Yeast    58 KAGTKVGIVGRTGAGKSSIIAAIYRLSDWENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDG 122

  Fly  1167 TMRYNLDPFDEYSDAKLWESLEEVKLKQVVADL--------PS-----------GLQSKISEGGT 1212
            |:|.||||||.|||.:::..|.:|.|.:...:|        |:           .|.:.:..||:
Yeast   123 TVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGS 187

  Fly  1213 NFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMD 1277
            |.|.|||||:||||::|....|:::|||||::|..:||.||.|||...|:.|:|||||||.:|:|
Yeast   188 NLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVID 252

  Fly  1278 SDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQ 1327
            .||:|||:.|:..|:..|:.|: :....:|:.:.:|:|:  |:.|.::|:
Yeast   253 YDKILVMEMGRVKEYDHPYTLI-SDRNTIFYRLCRQSGE--FENLFELAK 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	123/281 (44%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371
		ABCC_MRP_domain2	1074..1295	CDD:213211	108/242 (45%)
YKR104W	NP_013030.1	ABCC_NFT1	27..270	CDD:213269	110/246 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830