Protein Alignment Mrp5 and NFT1

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_013029.3
• Gene: NFT1 / 853978
• SGDID: S000001811
• Length: 1218
• Species: Saccharomyces cerevisiae
• Alignment Length: 1097
• Identity: 281/1097 - (25%)
• Similarity: 474/1097 - (43%)
• Gaps: 222/1097 - (20%)

  Fly     9 LPENPREK----SNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEV 69
            |.||..:|    ..:|..|.|.......:|..|..|...|:                   |:.::
Yeast   234 LVENENKKLPPAPTVFGLLTFSRIDRLIWKAYKHCLGNADI-------------------WDLDI 279

  Fly    70 EKK------------RKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYY 122
            ..|            :|.:..|:::.....||   ::.|.|......:.|  ...|.:..:::|.
Yeast   280 NNKSIAILANFEMSSKKGRLLPNIICYFKAVF---ISQLFLAFVSSFLNF--VPSLLMPRILSYV 339

  Fly   123 ADASNQEGDNQTKAYLYALGV--ILTSACNVLFMHPYMLGMFHIG----MKARIAMTSMIYRKAL 181
            .|..::.. |....|:.::.|  |:.:.|.       ..|:| :|    |:.|..:.|.||.|.|
Yeast   340 NDPKSKSW-NLVSLYVSSMLVSKIIATTCR-------GQGLF-LGEKGTMQLRTVLISNIYSKTL 395

  Fly   182 RLSRTALGDTTI-----------------------------GQVVNLISNDVGRLDVSVIHMNYL 217
            |  ||.|.|:|.                             ..|.|::|.|..::..:   ||..
Yeast   396 R--RTILKDSTTSLQKNASTSFEENPDSSEAEPRKKSSRKDNSVNNVMSIDAFKVSEA---MNTF 455

  Fly   218 WLGPVEIGI-ITYLM--YREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMN 279
            :|....:.: :|.||  |..:|.|||.|...:|..|||..:........:....:.||:|...::
Yeast   456 YLACEAVFMTVTALMILYSLLGWSAFAGTFALLAMIPLNFWCATFYGNYQADQLILTDKRTSGIS 520

  Fly   280 EIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRN----------VNYIRGTLQSFIMFVTRISV 334
            |.::.|:|||:.|||..|.:.|..||..|:..::.          :.:...||.|.|.|    ||
Yeast   521 EALNSIRVIKLLAWENLFYQKIINVRDGEIRLLKKKATIFFLNHLIWFFGPTLVSAITF----SV 581

  Fly   335 FVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKV 399
            |:.     ...:.||...||...:.:.|||..|. .....:|...:..:|:.|||.::...||:
Yeast   582 FIK-----FQNQTLTPTIAFTALSLFAILRTPMD-QIASTVSLLIQSFISLERIQDYLNESETR- 639

  Fly   400 RDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNI 464
              |.|.| ||...|.|                             ......:|:...|...|.||
Yeast   640 --KYEIL-EQSNTKFG-----------------------------FEDASMEWEAAETSFKLKNI 672

  Fly   465 SLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKV----------------NGTLSYASQ 513
            |:.||...|.|:|||.|||||||:..:|||||..||.:.|                ..:::|.||
Yeast   673 SIDFKLNSLNAIIGPTGSGKSSLLLGLLGELNLLSGKIYVPTVESRDDLEIGKDGMTNSMAYCSQ 737

  Fly   514 EPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISL 578
            .|||.:||::.|::||...:|.::..|:|.|.|::|.:.:....:|.||:.|.||||||:.||:|
Yeast   738 TPWLISGTIKDNVVFGEIFNKQKFDDVMKSCCLDKDIKAMTAGIRTDVGDGGFSLSGGQQQRIAL 802

  Fly   579 ARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRG-FLREEIVLLVTHQLQFL-EQADVIVIMDK 641
            |||:|..:...:|||.|||||.....:::::|:.| .::....::.:|.:..: ::||.:||:|:
Yeast   803 ARAIYSSSRYLILDDCLSAVDPETALYIYEECLCGPMMKGRTCIITSHNISLVTKRADWLVILDR 867

  Fly   642 GKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAES 706
            |::.:.|....:.||. :|.:...:...|:........|:|.:.:.:|..|..|..|..|..||
Yeast   868 GEVKSQGKPSDLIKSN-EFLRESINNDSKNTTHNQIDLKRSTTSKKTKNGDPEGGNSQDEVCAE- 930

  Fly   707 LAAESPMQTQEGRVEGRIGMKLYK---KYFGANGYGLFIVFAF----FCIGAQVLASGGDIFLSY 764
              .|:   .:|.::||.:....||   .|||    ||.:||.|    ..|....|:.|  .:|.|
Yeast   931 --VEN---FEETKMEGSVKFSAYKWLADYFG----GLGVVFVFTSSSILIHGITLSQG--FWLRY 984

  Fly   765 WVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLF---FYLAMR 826
            |::......:.|::.|:.....           :||:.    ::.||..||.|.|.   .::|:.
Yeast   985 WLDTGSSGSKSTWLYRIVEGHS-----------NIYFL----LTYIIIGLVSSFLTSGKVWIAII 1034

  Fly   827 SSTTLHNTMF----QGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGI 887
            |.|.:...:|    ..:..|.:.|.|..|:|||:||||||:..:|:.|......:....:..:.|
Yeast  1035 SGTNVTKKIFAKLLSSILYAKLRFHNVTPTGRIMNRFSKDMDIIDQQLIPNFEGLSYSVVVCLWI 1099

  Fly   888 VVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFG 952
            ::::..:...::|..:.|..::|.:...||..||::||::.:..|||:...:.::.|:.||||..
Yeast  1100 ILLIGYVTPQFLLFAIPLCALYYTVCTLYLRASRELKRIDNINISPIHQLFAEAIKGVTTIRALA 1164

  Fly   953 AQKELIAE----FDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFS 1005
            .::..|.:    .|.   .::..:|:.:||.     |     :.|...|..:..|||
Yeast  1165 DERRFITQSLVAIDR---SNAPFFYLNMATE-----W-----ITYRVDIIGTLVLFS 1208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	267/1011 (26%)
NFT1	NP_013029.3	MRP_assoc_pro	252..>1218	CDD:188098	276/1079 (26%)