DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4562 and STE6

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_012713.1 Gene:STE6 / 853671 SGDID:S000001692 Length:1290 Species:Saccharomyces cerevisiae


Alignment Length:1368 Identity:303/1368 - (22%)
Similarity:543/1368 - (39%) Gaps:304/1368 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 LVAYYADASNQEGDNQTKAYLY------ALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMI 176
            |..:.|:.|:|.        ||      ::.|:...|.:|..|...:....|||.:....:.|.|
Yeast    55 LSVFVANGSHQG--------LYSQLVQRSMAVMALGAASVPVMWLSLTSWMHIGERQGFRIRSQI 111

  Fly   177 YRKALR--------LSRTALGD-TTIGQVVNLISNDVGRLDVSVIHMN-------------YLWL 219
            ....|.        .:...||| |.|.:.|..:.:...... ::...|             |.| 
Yeast   112 LEAYLEEKPMEWYDNNEKLLGDFTQINRCVEELRSSSAEAS-AITFQNLVAICALLGTSFYYSW- 174

  Fly   220 GPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISG 284
                  .:|.::.....|..||.|....:   :..|..|:.|        .|.:..:::...::.
Yeast   175 ------SLTLIILCSSPIITFFAVVFSRM---IHVYSEKENS--------ETSKAAQLLTWSMNA 222

  Fly   285 IQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTL-----QSFIMFVTRISVFVSLVGF--- 341
            .|::::|.     ::.:...:.||:....|..:|:...     ...:.|:| :::||.  ||   
Yeast   223 AQLVRLYC-----TQRLERKKFKEIILNCNTFFIKSCFFVAANAGILRFLT-LTMFVQ--GFWFG 279

  Fly   342 ---VLLGKLLTAEKAFVITAYY------NILRNTMTVYFPMGISQFAELL---VSIRRIQTFMLH 394
               :..|||...:   |||.::      :.|.||        :.|...|.   |::.:|.|.:  
Yeast   280 SAMIKKGKLNIND---VITCFHSCIMLGSTLNNT--------LHQIVVLQKGGVAMEKIMTLL-- 331

  Fly   395 EETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDN 459
                 :|.|:   ...|.|       |||...    |....||:    :..:.:...:..:.::.
Yeast   332 -----KDGSK---RNPLNK-------TVAHQF----PLDYATSD----LTFANVSFSYPSRPSEA 373

  Fly   460 TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNG-------------TLSYA 511
            .|.|:||.|...|...::|..|||||:|...:|...:..:||:.:||             .::..
Yeast   374 VLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGYNGSISINGHNIQTIDQKLLIENITVV 438

  Fly   512 SQEPWLFTGTVRQNILFG-----------LPMDKHRYRTVVKRCALERDFELLPYADKTIVGERG 565
            .|...||..|:|:|||.|           ...::|..:...:...|:|....||...:|::|..|
Yeast   439 EQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGG 503

  Fly   566 ASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFL 630
            .:|||||:.|:::|||..|...|..||:.:||:|. |.|:|..:.:|.:.:.:..:::||:|..:
Yeast   504 VTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDI-VHRNLLMKAIRHWRKGKTTIILTHELSQI 567

  Fly   631 EQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEG----AGDAPDKKSLSRQNSKLR 691
            |..|.:.:|.:|::...||.          :::|.||:.....    ..|..|.|::....::.:
Yeast   568 ESDDYLYLMKEGEVVESGTQ----------SELLADPTTTFSTWYHLQNDYSDAKTIVDTETEEK 622

  Fly   692 DRHGSISSMESAAES------------------------LAAESPMQTQEGRV-EGRIG------ 725
            ..| ::.|..|..|:                        ....|.::|:..:| |..||      
Yeast   623 SIH-TVESFNSQLETPKLGSCLSNLGYDETDQLSFYEAIYQKRSNVRTRRVKVEEENIGYALKQQ 686

  Fly   726 --------------MKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDT 776
                          :::.|:...:..|...::....|   .::|...:...||           |
Yeast   687 KNTESSTGPQLLSIIQIIKRMIKSIRYKKILILGLLC---SLIAGATNPVFSY-----------T 737

  Fly   777 FMARLRRAFPETRINADTDPVDIYYFT-------GINVSVIIFSLVRSMLFFYLAMRSSTTLHNT 834
            |...|....|.|    |......:|..       |:..:..||:..:..|....:......|.|.
Yeast   738 FSFLLEGIVPST----DGKTGSSHYLAKWSLLVLGVAAADGIFNFAKGFLLDCCSEYWVMDLRNE 798

  Fly   835 MFQGVTRAAMHFFN--TNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVW 897
            :.:.:||..|.:|:  .|.:..|......||..:..:: |..:..|..|:.:..|.::..:::.|
Yeast   799 VMEKLTRKNMDWFSGENNKASEISALVLNDLRDLRSLV-SEFLSAMTSFVTVSTIGLIWALVSGW 862

  Fly   898 ---YILATVF-LVIVFYLLRVFYL-STSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKEL 957
               .:..::| |:|:|..:....| ....|.|...|...:.:|.    .:..:.||:.      |
Yeast   863 KLSLVCISMFPLIIIFSAIYGGILQKCETDYKTSVAQLENCLYQ----IVTNIKTIKC------L 917

  Fly   958 IAEFD---NYQDMHSSGYYMFLATSRA----FGYWLDCVCVVYIAVITLSFFL--------FSPE 1007
            .|||.   .|.|:...  ...:|:.||    ||..:..:.|:.|..|...:.|        .|.|
Yeast   918 QAEFHFQLTYHDLKIK--MQQIASKRAIATGFGISMTNMIVMCIQAIIYYYGLKLVMIHEYTSKE 980

  Fly  1008 NGGDVGLAITQAMGMTGMV-------------QWGMRQSAELENTMTAVERVVEYEDLEPEG--- 1056
            ......|.:...|..|.:|             .|..|...|..||:.     ||..:....|   
Yeast   981 MFTTFTLLLFTIMSCTSLVSQIPDISRGQRAASWIYRILDEKHNTLE-----VENNNARTVGIAG 1040

  Fly  1057 -DFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSS 1120
             .:..| .|||        .:...:|:..| |.....:|.:::|..:...:.:||:|.:|.|||:
Yeast  1041 HTYHGK-EKKP--------IVSIQNLTFAY-PSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKST 1095

  Fly  1121 LINALFRLSYN--EGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNL--DPFDEYSDA 1181
            |:..|.:| ||  .|.|.||..|.||..|..||.:||::.|:|:||:||:|.||  ...||..:.
Yeast  1096 LVLLLTKL-YNCEVGKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEI 1159

  Fly  1182 KLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDP 1246
            :::::|:.|.:...|...|.||.::|..  |..|.||.|.:|:|||:||:::||::||.|:.:|.
Yeast  1160 EMYDALKYVGIHDFVISSPQGLDTRIDT--TLLSGGQAQRLCIARALLRKSKILILDECTSALDS 1222

  Fly  1247 QTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMV 1311
            .:.::|...::........:.|.|....:...:.:.|:..||.||.|: |:.|..:..::|..:.
Yeast  1223 VSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGN-FDTLYNNRGELFQIVS 1286

  Fly  1312 KQT 1314
            .|:
Yeast  1287 NQS 1289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 300/1352 (22%)
ABC_membrane 98..367 CDD:294371 54/293 (18%)
ABCC_MRP_domain1 443..643 CDD:213217 61/223 (27%)
ABC_membrane 799..1027 CDD:294371 52/269 (19%)
ABCC_MRP_domain2 1074..1295 CDD:213211 73/224 (33%)
STE6NP_012713.1 MdlB 24..605 CDD:224055 137/631 (22%)
MdlB 702..1289 CDD:224055 152/636 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.