DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and YOR1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1441	Identity:	447/1441 - (31%)
Similarity:	732/1441 - (50%)	Gaps:	189/1441 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPREK-------SNIFSSLMFCFAMPTFFKGRKKTLDENDLY----RALQEHRS 54
            :.|.|..|:|:...|:       :||.|::.|.:.:|....|.|:|:..|||:    |...|...
Yeast    90 LHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLY 154

  Fly    55 DHLGSKLSAAWEKEVEKKRKK------------KKTP--SLLKASMNVFGWRLAGLGLVLFIL-- 103
            |.....:...:||..:|.||:            .|.|  ::|:|.:..|. :...:.:|..||
Yeast   155 DDFEKNMIYYFEKTRKKYRKRHPEATEEEVMENAKLPKHTVLRALLFTFK-KQYFMSIVFAILAN 218

  Fly   104 -EIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVL-FMHPYMLGMFH--- 163
             ..||   .|:....|:.:..:.:.....:..|...||:|..|....|.| |.|     .||
Yeast   219 CTSGF---NPMITKRLIEFVEEKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNH-----FFHTSQ 275

  Fly   164 -IGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGII 227
             .|::|:..:|....:|....|..|......|:|.:.::.|:.|::.::....:|...|..:.|.
Yeast   276 LTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAIC 340

  Fly   228 TYLMYREIGISAFFGVAVML--LFIPLQAY---LGKKTSVLRLKTALRTDERVRMMNEIISGIQV 287
            ..|:...:|..|..|:.:..  .||.|.|:   ||     .|:...:.||.||.||.|:::.|::
Yeast   341 IVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILG-----FRIAANIFTDARVTMMREVLNNIKM 400

  Fly   288 IKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVSLVGFVLLGKLLTAEK 352
            ||.|.||..:.|.|..:||||::.:|.:...|..|.:..|.:..|:   |||.|:.:.|:....:
Yeast   401 IKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIA---SLVTFLAMYKVNKGGR 462

  Fly   353 ----AFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTF---------------------- 391
                .|...:.:.:|...| .:.|:.|....::::.:.|:|:.
Yeast   463 QPGNIFASLSLFQVLSLQM-FFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGFDP 526

  Fly   392 -----MLH-----EETKVRD-----KSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEH 441
                 |.|     |:.::.|     |.|..||.|..|      .....|.|  |||: .|::|:.
Yeast   527 KLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNK------KKRKDTWG--KPSA-STNKAKR 582

  Fly   442 SIVISKLKAKWDQKNTDNT----LDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSV 502
              :.:.||.:...::.:.|    ..:::...|..:.:.:.||:|:|||||:.|:.|.:....|.|
Yeast   583 --LDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKV 645

  Fly   503 KVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGAS 567
            :|||.|..... ||:...:||.||:||.|.:|.:|..||:.|:|:.|.::||..|.|.:||||.:
Yeast   646 EVNGDLLMCGY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGIT 709

  Fly   568 LSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQ 632
            |||||||||:|||:||:|.||||.||.|||||:.||:|:.|:|:.|.|..:..:|.||||..:|:
Yeast   710 LSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIER 774

  Fly   633 AD-VIVIMDKGKISAMGTYESMAKSGLDFAQML----TDPSKKDEG-----AGDAPDKKSLSRQN 687
            |. |||:...|::. :||.:.:.........:|    .:..|:||.     ||:....|..| :.
Yeast   775 ASRVIVLGTDGQVD-IGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYES-EV 837

  Fly   688 SKLRDRHGSISSMESAAES--LAAESPMQTQEGRVEGRIGMKLYKKYF----GANGYGLFIVFAF 746
            .:|.:.....:.|...|.|  :.|:....::|.|....|.:|:|::|.    |..|:....::|.
Yeast   838 KELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAI 902

  Fly   747 FCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVII 811
            ..:|....:....::||||.....:....:|.                  :.:|.|  ...:..|
Yeast   903 LVVGTTFCSLFSSVWLSYWTENKFKNRPPSFY------------------MGLYSF--FVFAAFI 947

  Fly   812 FSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMD 876
            |...:..:...:.:.:|..|:....:.:....|.:.:|.|.|||||||:||...:|..|...:..
Yeast   948 FMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRL 1012

  Fly   877 VMQIFLAIVGIVVVLCIINV-WYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSA 940
            :...|..||| |.|:||:.: |:.:|..||:::|.|:...|.|:.|::||||||.||.:|::|:.
Yeast  1013 MTSQFANIVG-VCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNE 1076

  Fly   941 SLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITL-----S 1000
            .|.|:.||:|:.:|:..:|:.|...:..:...|:.:...|..|.:||.|.:.:..:|||     :
Yeast  1077 VLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVAIAFALIITLLCVTRA 1141

  Fly  1001 FFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY-EDLEPEGDFESKPNK 1064
            |    |.:...||:.:|..:.:.|::...:|...:.||.|.:.||:|.| .:|..|..:. ||..
Yeast  1142 F----PISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYR-KPEM 1201

  Fly  1065 KPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLS 1129
            .||:.||..|:|:|:::...|.|  ....||::||:.|:..||:||.||||||||::::||:||
Yeast  1202 TPPESWPSMGEIIFENVDFAYRP--GLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRL- 1263

  Fly  1130 YNE---GAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWES----- 1186
             ||   |.||||..|.:.|||.|||.|::||||:||||.||:|.|||||:|.:|.:||::
Yeast  1264 -NELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGG 1327

  Fly  1187 ------LEEVKLKQVVADLPSG------LQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1239
                  |.||||::...:...|      |...:.|.|:|||:|:|||:.|.||::|:::||::||
Yeast  1328 AIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDE 1392

  Fly  1240 ATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEK 1304
            ||::||.:||..|||.|..:|.|||:|.|||||.|:::.|::||::.|:..||.:|:.|. :.|.
Yeast  1393 ATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEFDTPWTLF-SQED 1456

  Fly  1305 KVFHSMVKQTG 1315
            .:|.||..::|
Yeast  1457 SIFRSMCSRSG 1467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	438/1413 (31%)
		ABC_membrane	98..367	CDD:294371	73/285 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	87/204 (43%)
		ABC_membrane	799..1027	CDD:294371	70/233 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	112/240 (47%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	447/1439 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.710