DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and YCF1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_010419.3	Gene:	YCF1 / 851713	SGDID:	S000002542	Length:	1515	Species:	Saccharomyces cerevisiae

Alignment Length:	1371	Identity:	482/1371 - (35%)
Similarity:	743/1371 - (54%)	Gaps:	137/1371 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKK 76
            ||.:.:||||.:.|.:.......|.:|.|.|.|||:..:...|:.|..||...||.|:    |:|
Yeast   210 NPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENEL----KQK 270

  Fly    77 KTPSLLKASMNVFGWRLAGLGLVLFILEIG--FRVTQPLFLGGLVAYYADASNQEGDNQT----- 134
            ..|||..|....||.::.   |..|...|.  ...|||..|..|:.:..|.:::..|:.:
Yeast   271 SNPSLSWAICRTFGSKML---LAAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQGF 332

  Fly   135 -----------KAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTAL 188
                       :.:|.|..:.|........:|.|.|.:|:.||..:.|:|::||:|:|.||..|.
Yeast   333 ENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEAS 397

  Fly   189 GDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQ 253
            |.::.|.:|||:|.||.:|......:|.:|.||.:|.|..|.:|:.:|.|.:.||.::::.:||.
Yeast   398 GLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLN 462

  Fly   254 AYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVR-TKEMNAIRNVN- 316
            ::|.:....|:.......|||.|:::||::.|:.:|:||||.|:.:.:..|| .||:..:..:.
Yeast   463 SFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGC 527

  Fly   317 YIRGT-----LQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGIS 376
            |:..|     :..|::.....:|||     ....:.||.:..|.....:|:|...:.: .||.::
Yeast   528 YMAVTSFQFNIVPFLVSCCTFAVFV-----YTEDRALTTDLVFPALTLFNLLSFPLMI-IPMVLN 586

  Fly   377 QFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEH 441
            .|.|..|||.|:.||..:||.      :....|:|.|...|.:  ||...|
Yeast   587 SFIEASVSIGRLFTFFTNEEL------QPDSVQRLPKVKNIGD--VAINIG-------------- 629

  Fly   442 SIVISKLKAKWDQK-NTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVN 505
                ......|.:| .....|.||:.:.|...|..::|.|||||::|:..:||:|....|...|:
Yeast   630 ----DDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVH 690

  Fly   506 GTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSG 570
            |:::|.||.||:..|||::|||||...|...|...:|.|||..|..:|...|||:|||:|.||||
Yeast   691 GSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSG 755

  Fly   571 GQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQA 633
            |||||:|||||||.:||.|||||||:|||.||.|||.:..:  .|.|..:..:|.|:::..|..|
Yeast   756 GQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIA 820

  Fly   634 DVIVIMDKGKISAMGTYESMAK-SGLDFAQMLTDPSKKDEGA----GDAPDKKSLSRQNS----- 688
            |.|.::|.|:|:..|||:.:.| :.....::|.:..||:.|.    ||:  .:|..|::|
Yeast   821 DSIALLDNGEITQQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFGDS--SESSVRESSIPVEG 883

  Fly   689 ------KLRD----RHGSISSMESAAESLAA-----ESPMQTQEGRVEGRIGMKLYKKYFGANGY 738
                  ||.|    ...:||...::..:|.:     :..:..:|.|.:|::...:|.:|..|...
Yeast   884 ELEQLQKLNDLDFGNSDAISLRRASDATLGSIDFGDDENIAKREHREQGKVKWNIYLEYAKACNP 948

  Fly   739 GLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFT 803
            ....||..|.:.:..|:..|:::|.:|...|.....:...||.               :.||:..
Yeast   949 KSVCVFILFIVISMFLSVMGNVWLKHWSEVNSRYGSNPNAARY---------------LAIYFAL 998

  Fly   804 GIN--VSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQV 866
            ||.  ::.:|.::|   |:.:..:.:|..|||.|...|.||.|.||.|.|.||||||||.|:.:|
Yeast   999 GIGSALATLIQTIV---LWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKV 1060

  Fly   867 DEILPSVMMDVMQIFLAIVGIVVVLCII--NVWYILATVFLVIVFYL-LRVFYLSTSRDVKRLEA 928
            |.:|....   .|.|:..|.:...:.:|  ..|..:..:..:.|||: .:.:||.|||:::||::
Yeast  1061 DALLGRTF---SQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDS 1122

  Fly   929 VTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQ----DMHSSGYYMFLATSRAFGYWLDCV 989
            :||||||||...:|.||||:|.:..||    .|.:..    |.:.|.:|..:..:|...|.|:.:
Yeast  1123 ITRSPIYSHFQETLGGLATVRGYSQQK----RFSHINQCRIDNNMSAFYPSINANRWLAYRLELI 1183

  Fly   990 -CVVYIAVITLSFFLFSPE--NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYED 1051
             .::.:...|||.|.....  ..|.|||:::.|:.:|..:.|.:|.:.|:|..:.:|||:.||.|
Yeast  1184 GSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYAD 1248

  Fly  1052 LEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGA 1116
            |:.|.....: ..:|||:||..|.|.|::.|.:|.|:  .|.||:.:||.|:..|||||||||||
Yeast  1249 LKSEAPLIVE-GHRPPKEWPSQGDIKFNNYSTRYRPE--LDLVLKHINIHIKPNEKVGIVGRTGA 1310

  Fly  1117 GKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD 1180
            |||||..|||| :..:||.|:||....|::||:|||.|:|||||:..:|.||:|.|:||.::|:|
Yeast  1311 GKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTD 1375

  Fly  1181 AKLWESLEEVKLKQVVADLPS-GLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANV 1244
            ..:|.:||...||:.|..:.: ||.::::|||.|.|||||||:|||||:|..::|||:|||||.|
Yeast  1376 EAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAV 1440

  Fly  1245 DPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHS 1309
            |.:||.::|.|||..|||.|:|||||||:|:||||:::|:|.||..||.||.:|| :..|.:|:|
Yeast  1441 DVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLL-SDNKSLFYS 1504

  Fly  1310 MVKQTG 1315
            :..:.|
Yeast  1505 LCMEAG 1510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	477/1354 (35%)
		ABC_membrane	98..367	CDD:294371	81/293 (28%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/202 (45%)
		ABC_membrane	799..1027	CDD:294371	80/239 (33%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	121/222 (55%)
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	482/1371 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720