DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and YBT1

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_013052.1 Gene:YBT1 / 850678 SGDID:S000003971 Length:1661 Species:Saccharomyces cerevisiae


Alignment Length:1461 Identity:447/1461 - (30%)
Similarity:744/1461 - (50%) Gaps:218/1461 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KADE-LPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE 68
            |.|. :..:|...::|...:.:.:.....:|..|.::...|::..:.:..|..:..|.....:.:
Yeast   271 KTDSWITPSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHK 335

  Fly    69 VEKKRKKKKTPSLLKASMNVF-----------GWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYY 122
            |::||         ..|:|:|           .|  |.||.||..:       ..:.|..::.|.
Yeast   336 VKRKR---------IFSLNLFFFFSNYLVLQCFW--AFLGSVLSFI-------PTVLLKRILEYV 382

  Fly   123 ADASNQEGDNQTKAYLYA----LGVILTSAC--NVLFMHPYMLGMFHIGMKARIAMTSM----IY 177
            .|.|:...:   .|:.|.    :|.||.:.|  ..||          .|.:..|.|.|:    ||
Yeast   383 EDQSSAPSN---LAWFYVTVMFVGRILVAICQAQALF----------FGRRVCIRMKSIIISEIY 434

  Fly   178 RKALRL-------------------SRTALGD------TTIGQVVNLISNDVGRLDVSVIHMNYL 217
            .||||.                   .::..||      ..:|.::||::.|..::.....:::..
Yeast   435 TKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSF 499

  Fly   218 WLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEII 282
            ....|...:...|:||.:|.:|..||.:::..:||...|.|....|:.|....||.|::.:||..
Yeast   500 LEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAF 564

  Fly   283 SGIQVIKMYAWEIPFSKMINYVRTKEMNAI--RNVNYIRGTLQSFIMFVTRISVFVSLVGFVLL- 344
            ..|::||.::||..|.|.||.:|..|::.:  |::.:   ::.||:.|||...|..:...:.:. 
Yeast   565 QAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVW---SISSFLWFVTPTIVTAASFAYYIYV 626

  Fly   345 -GKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDE 408
             |::||...||...:.:.:||:.:.....| :|...:..||:.|:|.|:...:||..|       
Yeast   627 QGEVLTTPVAFTALSLFTLLRDPLDRLSDM-LSFVVQSKVSLDRVQDFLNENDTKKYD------- 683

  Fly   409 QKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQL 473
                           |.|  :.|:..|.: .|:|.:      .||:.|.|..|.:::::||..:|
Yeast   684 ---------------QLT--IDPNGNRFA-FENSTI------SWDKDNQDFKLKDLNIEFKTGKL 724

  Fly   474 VAVIGPVGSGKSSLIQAVLGELNPDSGSVKV-------------NGT---LSYASQEPWLFTGTV 522
            ..||||.||||:||:.|:|||:...:|.|.|             |||   ::|.||..||...||
Yeast   725 NVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTV 789

  Fly   523 RQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKAD 587
            :.||||..|.::.||:.||:.|.|:||||:|...|.|.:||:|.:||||||.|:|||||:|..|.
Yeast   790 KNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNAR 854

  Fly   588 IYLLDDPLSAVDTHVGRHLFDQCMRGFLREE-IVLLVTHQLQF-LEQADVIVIMDKGKISAMGTY 650
            ..||||.|||||:|....::|.|:.|.|.|: ..:||:|.:.. |..|:::|:::.|::...|..
Yeast   855 HVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDP 919

  Fly   651 ESMAKSGLDFAQMLTDPS--KKDEGAGDAPDKKSLSRQN-SKLRDRHGSISSMESAAESLAAESP 712
            ..|.:.||.....|...|  .:...:.:...|.|.|..| ..::::..|:::..|..|:...:..
Yeast   920 IDMLQKGLFGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKS 984

  Fly   713 MQT------------QEGRVEGRIGMKLYK---KYFGANGYGLFIVFAFFCIGAQVLASGGDIFL 762
            ::|            :|.:.||.:|:.:||   |.||  |:.:....|...:.||:|..|...::
Yeast   985 LRTEAERTEDGKLIKEETKEEGVVGLDVYKWYLKIFG--GWKIVSFLASLFLIAQLLYIGQSWWV 1047

  Fly   763 SYWVNKNGEAERDTFMARLRRAFP--------------ETRI---NADTDPVD----IYY---FT 803
            ..|.:.|..|:   .:.|.:||..              .::|   :|:..|..    :||   :.
Yeast  1048 RAWASHNVIAK---IIPRAQRAIAFISKKASHLIDWRGSSQISMASAENQPSSGHSTMYYLVLYL 1109

  Fly   804 GINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDE 868
            .|..:..:....:::|.|...:.:|..:.|.:...|..:.:.||:..|:|||:||||||:..:|:
Yeast  1110 IIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQ 1174

  Fly   869 ILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSP 933
            .|...:.......:..:..|:::..|...::...:.:.|::|.:..||::.||::||.|:::|||
Yeast  1175 ELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSP 1239

  Fly   934 IYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAV 996
            ||.|.|.:|.|:.||||||.:...:.|..:..|.::..::.....:|...:.:|.:  .|::.|.
Yeast  1240 IYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLWVANRWLAFRIDMIGSLVIFGAG 1304

  Fly   997 ITLSFFLFSPEN--GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFE 1059
            :   |.||:..|  .|..|:::|.|:..|....|.:|..:|:|..|.:||||.||.::|.|...|
Yeast  1305 L---FILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNE 1366

  Fly  1060 SKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINA 1124
            .|  :.||..||:||||..:||||:|.|:  ...|:::::.:::...|:|||||||||||::|.|
Yeast  1367 HK--EIPPPQWPQDGKIEVNDLSLRYAPN--LPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITA 1427

  Fly  1125 LFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLE 1188
            ||| |....|.|.||..|.:.:.|..||..|:||||:|.|||||::.||||:||:||.:::|:|:
Yeast  1428 LFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALK 1492

  Fly  1189 EVKL-----------KQVVADLPS----------GLQSKISEGGTNFSVGQRQLVCLARAILREN 1232
            .|.|           ::...:..|          .|.|:|||||:|.|.|||||:||||::||..
Yeast  1493 RVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSP 1557

  Fly  1233 RILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFE 1297
            :|:::|||||::|..:||.||.|||.:|:..|:|||||||.:|:|.||:||||||:..|:..|:.
Yeast  1558 KIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYS 1622

  Fly  1298 LLTTSEKKVFHSMVKQTGDSTFDALLKVAQK 1328
            || .:::..|:||.:.:|:  .|.|:::|:|
Yeast  1623 LL-LNKQSAFYSMCEHSGE--LDILIELAKK 1650

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 436/1423 (31%)
ABC_membrane 98..367 CDD:294371 74/307 (24%)
ABCC_MRP_domain1 443..643 CDD:213217 91/217 (42%)
ABC_membrane 799..1027 CDD:294371 63/234 (27%)
ABCC_MRP_domain2 1074..1295 CDD:213211 114/242 (47%)
YBT1NP_013052.1 MRP_assoc_pro <353..1639 CDD:188098 427/1355 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344646
Domainoid 1 1.000 64 1.000 Domainoid score I2425
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.640

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