Protein Alignment CG4562 and BPT1

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_013086.1
• Gene: BPT1 / 850645
• SGDID: S000003938
• Length: 1559
• Species: Saccharomyces cerevisiae
• Alignment Length: 1382
• Identity: 449/1382 - (32%)
• Similarity: 711/1382 - (51%)
• Gaps: 169/1382 - (12%)

  Fly    37 KKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLF 101
            ||..|.|.|.....:.....:..:..|.||.|....|.     ||.:|....|| |...:.::..
Yeast   241 KKIKDPNQLPLPPVDLNIKSISKEFKANWELEKWLNRN-----SLWRAIWKSFG-RTISVAMLYE 299

  Fly   102 ILEIGFRVTQPLFLGGLVAYYADASNQEGDNQ---TKAYLYALGVILTSACNVLFMHPYMLGMFH 163
            .......|.||.||    ..:.|..|.|..::   ......||.:.:.|..:|...:.:.:|:|.
Yeast   300 TTSDLLSVVQPQFL----RIFIDGLNPETSSKYPPLNGVFIALTLFVISVVSVFLTNQFYIGIFE 360

  Fly   164 IGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIIT 228
            .|:..|.::.|::|:|:|||:.....:.:.|.::||:|.||.|:.....:...:...|::|.::.
Yeast   361 AGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVL 425

  Fly   229 YLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALR-TDERVRMMNEIISGIQVIKMYA 292
            ..:|..:|.:...|:..|.:.:|:.|:|.:|...|. ||.:: .|.|::.:.|:::.|:.||:||
Yeast   426 TSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLS-KTQMKYKDMRIKTITELLNAIKSIKLYA 489

  Fly   293 WEIPFSKMINYVRT-KEMNAIRNVNYIRGTLQSFIMFVTR-ISVFVSLVGFVLLGKL----LTAE 351
            ||.|....:|:||. .|:...|.:    |.:.:.|.|... :.:.|:...|.|....    |:..
Yeast   490 WEEPMMARLNHVRNDMELKNFRKI----GIVSNLIYFAWNCVPLMVTCSTFGLFSLFSDSPLSPA 550

  Fly   352 KAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEE---TKVRDKSEDLDEQKLGK 413
            ..|...:.:||| |:.....|..|:...|..||:.|:::|:|.:|   :.:.......||:.|
Yeast   551 IVFPSLSLFNIL-NSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDDSFIERIDPSADERAL-- 612

  Fly   414 AGLIAEPTVAQT--TGVLKPSSRRTSEA--------EHSIVISKLKAKWDQKNTDNTLDNISLKF 468
                  |.:...  |.:.|.....||..        |.||:.|...|   .||.|:      .:.
Yeast   613 ------PAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIA---LKNIDH------FEA 662

  Fly   469 KPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGS--------VKVNGTLSYASQEPWLFTGTVRQN 525
            |...||.|:|.||:|||:.::|:||:|...|||        :..:.:::|.|||.|:...:||:|
Yeast   663 KRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVREN 727

  Fly   526 ILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYL 590
            ||||...|:..|...:|.|.|..|.::||..|:|:|||:|.|||||||||:|||||||.:|||||
Yeast   728 ILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYL 792

  Fly   591 LDDPLSAVDTHVGRHLFDQCMRG---FLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYE- 651
            |||.|||||..|.:::.:..:.|   .|:.:.::|.|:.:..|:.:.:|..::.|:|...|.||
Yeast   793 LDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYED 857

  Fly   652 --------SMAKSGL-DFAQMLTDPSKKD-------EGAGDAPDKKSLSRQNS------------ 688
                    |..|..| :|...:.:.::.|       |...|.|.:..::...:
Yeast   858 VMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELEL 922

  Fly   689 -KLRDRHGSISSMES----AAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFC 748
             |...|..|::::..    .|:..:.:...|..|....||:..|:|..|..|.|....::|..|.
Yeast   923 IKANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKACGVLGVVLFFLFM 987

  Fly   749 IGAQVLASGGDIFLSYWV---NKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTG----IN 806
            |..:|.....:.:|.||.   .|||..||                        ::.|.|    |.
Yeast   988 ILTRVFDLAENFWLKYWSESNEKNGSNER------------------------VWMFVGVYSLIG 1028

  Fly   807 VSVIIFSLVRS-MLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEIL 870
            |:...|:.:|| |:..|.::|.|..||.:|.:.|.|:.|.||.|.|.|||:||||.|:..||..|
Yeast  1029 VASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNL 1093

  Fly   871 PSVMMDVMQIFLAIVGIVVVLCIINV-WYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPI 934
            ..:.....:..|..: :.|:|...|: |:::..:|||:::...:.||:..||::|||.:::.|||
Yeast  1094 QYIFSFFFKSILTYL-VTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPI 1157

  Fly   935 YSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-------CVCVV 992
            .|.:|.||||.:.|.|:...:..|  :.||:.:..:..::|  ..|:...||.       ...|:
Yeast  1158 MSLMSESLNGYSIIDAYDHFERFI--YLNYEKIQYNVDFVF--NFRSTNRWLSVRLQTIGATIVL 1218

  Fly   993 YIAVITLSFFLFSPE-NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEG 1056
            ..|::.|:......: :.|.|||.::.::.:||.:.|.:|.:..:|..:.:|||:|||.:|.||.
Yeast  1219 ATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEA 1283

  Fly  1057 DFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSL 1121
            . ...|.|:|.::||..|.|.|.:.|.||  .:..|.||.::|:.||.|||||||||||||||:|
Yeast  1284 Q-SINPEKRPDENWPSKGGIEFKNYSTKY--RENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTL 1345

  Fly  1122 INALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWE 1185
            ..|||| |...||.|:||..|.:|:||.||||.::||||:...|.||::.|||||:.||:.:|..
Yeast  1346 SLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKR 1410

  Fly  1186 SLEEVKLK----QVVADLPSG-------------LQSKISEGGTNFSVGQRQLVCLARAILRENR 1233
            ::|:..||    :::...|.|             |..||:|.|:|.|||||||:|||||:|..::
Yeast  1411 AVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSK 1475

  Fly  1234 ILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFEL 1298
            |||:|||||:||.:||.:||.|||.:|||.|:||||||:.||:||||::|:|.|...||.||.:|
Yeast  1476 ILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKL 1540

  Fly  1299 LTTSEKKVFHSMVKQTG 1315
            | :.:..:|:|:.::.|
Yeast  1541 L-SDKTSIFYSLCEKGG 1556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	445/1365 (33%)
		ABC_membrane	98..367	CDD:294371	70/278 (25%)
		ABCC_MRP_domain1	443..643	CDD:213217	85/210 (40%)
		ABC_membrane	799..1027	CDD:294371	74/241 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	123/238 (52%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	448/1380 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650