DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC11

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001319112.1	Gene:	ABCC11 / 839922	AraportID:	AT1G30420	Length:	1495	Species:	Arabidopsis thaliana

Alignment Length:	1355	Identity:	470/1355 - (34%)
Similarity:	744/1355 - (54%)	Gaps:	134/1355 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPEN----PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKL 61
            :.:::.|.||..    |...::|||.:.|.:..|....|.:|.:.|.|:::..|..:::.|..:.
plant   212 LDNVEYDALPGGVNICPERYASIFSGIYFSWMTPLMQLGYRKPITERDVWQLDQWDQTETLIKRF 276

  Fly    62 SAAWEKEVEKKRKKKKTPSLLKASMNVFGWR--LAGLGLVLFILEIGFRVTQPLFLGGLVAYYAD 124
            ...|   .|:.|:.|  |.||:|..|..|.|  |.|      |.::|..::|  |:|.::..:..
plant   277 QRCW---TEESRRPK--PWLLRALNNSLGRRFWLGG------IFKVGHDLSQ--FVGPVILSHIL 328

  Fly   125 ASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALG 189
            .|..|||.....|:||..:.......||....|...:..:|.:.|..:.:.|:.|:|||:..|..
plant   329 QSMIEGDPAWVGYVYAFLIFFGVTFGVLCQSQYFQHVGRVGFRLRSTLVAAIFHKSLRLTNKARK 393

  Fly   190 DTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQA 254
            :...|:|.|:|:.|...|.:....::.||..|..|.:...|:|:::|:::.||..::.|.||.|.
plant   394 NFASGKVTNMITTDANALQLIAEQLHGLWSAPFRIIVSMVLLYQQLGVASIFGSLILFLLIPFQT 458

  Fly   255 YLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIR 319
            .:.:|...|..:....||:||.::.||::.:.::|.||||..|...|..:|.:|::..|....:
plant   459 LIVRKMRKLTKEGLQWTDKRVGIIYEILASMDIVKCYAWEKSFESRIQGIRNEELSWFRKAQLL- 522

  Fly   320 GTLQSFIMFVTRISVFVSLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAEL 381
            ....|||:..|  .|.|:||.|   ||||..||..:||...:.:.:||:.::. .|..|||....
plant   523 SAFNSFILNST--PVVVTLVSFGVYVLLGGDLTPARAFTSLSLFAVLRSPLST-LPNLISQAVNA 584

  Fly   382 LVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVIS 446
            .||::||:..:|.||.                  ::|:      ...|:|.:       .:|.|.
plant   585 NVSLQRIEELLLSEER------------------ILAQ------NPPLQPGA-------PAISIK 618

  Fly   447 KLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGEL-NPDSGSVKVNGTLSY 510
            .....||.|.:..||.:|:|:.....|||::|..|.||:|||.|:|||| :.::.||.:.|:::|
plant   619 NGYFSWDSKTSKPTLSDINLEIPVGSLVAIVGGTGEGKTSLISAMLGELSHAETSSVDIRGSVAY 683

  Fly   511 ASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKAR 575
            ..|..|:|..|:|:|||||...:..||...:...||:.|.:|.|..|:|.:||||.::|||||.|
plant   684 VPQVSWIFNATLRENILFGSDFESERYWRAIDVTALQHDLDLFPGRDRTEIGERGVNISGGQKQR 748

  Fly   576 ISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMD 640
            :|:|||||..:|||:.|||.||:|.||...:||.|::..|:.:..:|||:||.||...|.|:::.
plant   749 VSMARAVYSNSDIYIFDDPFSALDAHVAHQVFDSCVKHELKGKTRVLVTNQLHFLPLMDRIILVS 813

  Fly   641 KGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAG--DAPDKKSLSRQN-SKLRDRHGSISSMES 702
            :|.|...|.:..::|||..|.:::       |.||  ||..:.:.:.:| |||    |...:::.
plant   814 EGMIKEEGNFAELSKSGTLFKKLM-------ENAGKMDATQEVNTNDENISKL----GPTVTIDV 867

  Fly   703 AAESLAA-------ESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFF-C-IGAQVLASGG 758
            :..||.:       .|.:..||.|..|.|...:..:|..|.| ||::|.... | :..:||....
plant   868 SERSLGSIQQGKWGRSMLVKQEERETGIISWDVVMRYNKAVG-GLWVVMILLVCYLTTEVLRVLS 931

  Fly   759 DIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDP---VDIYYFTGINVSVIIFSLVRSMLF 820
            ..:||.|.:               ::.|::     ..|   :.:|...|.....:.|:  .|...
plant   932 STWLSIWTD---------------QSTPKS-----YSPGFYIVVYALLGFGQVAVTFT--NSFWL 974

  Fly   821 FYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVM---MDVMQIFL 882
            ...::.::..||:.|...:.||.|.||.|||:||::||||||:|.:|..:.::|   |:.:...|
plant   975 ISSSLHAAKRLHDAMLNSILRAPMLFFETNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLL 1039

  Fly   883 AIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLAT 947
            :...::.::..|::|.|:.   |:|:||...::|.||||:|:||::|||||||:....:||||::
plant  1040 STFALIGIVSTISLWAIMP---LLILFYATYIYYQSTSREVRRLDSVTRSPIYALFGEALNGLSS 1101

  Fly   948 IRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWL----DCVCVVYIAVITLSFFLF---S 1005
            |||:.|. :.:|:. |.:.|.::  ..|...|.:...||    :.:..|.| .:|.:|.:.   :
plant  1102 IRAYKAY-DRMAKI-NGKSMDNN--IRFTLASTSSNRWLTIRSESLGGVMI-WLTATFAVLRYGN 1161

  Fly  1006 PEN----GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKP 1066
            .||    ...:||.::..:.:|.::...:||:::.||::.:||||..|.||..|.....: |.:|
plant  1162 AENQAVFASTMGLLLSYTLNITTLLSGVLRQASKAENSLNSVERVGNYIDLPSEATAIIE-NNRP 1225

  Fly  1067 PKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SY 1130
            ...||..|.|.|:|:.|:|.|  ....||..|:..:...||||:||||||||||::|||:|: ..
plant  1226 VSGWPSRGSIQFEDVHLRYRP--GLPPVLHGLSFFVYPSEKVGVVGRTGAGKSSMLNALYRIVEL 1288

  Fly  1131 NEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQV 1195
            .:|.||||..|....||.|||..:|||||.|||||||:|:|:|||.|::||.|||:||...:|.|
plant  1289 EKGRILIDDYDVAKFGLTDLRRVLSIIPQSPVLFSGTVRFNIDPFSEHNDADLWEALERAHIKDV 1353

  Fly  1196 VADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKF 1260
            :...|.||.:::||||.|||||||||:.||||:||.::||.:|||||:||.:||:|||.|||.:|
plant  1354 IDRNPFGLDAEVSEGGENFSVGQRQLLSLARALLRRSKILFLDEATASVDVRTDSLIQRTIREEF 1418

  Fly  1261 KDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |.||:|.|||||:|::|.||:||:.:|:.:|:.||.||| :.:...|..||..||
plant  1419 KSCTMLIIAHRLNTIIDCDKILVLSSGQVLEYDSPQELL-SRDTSAFFKMVHSTG 1472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	461/1327 (35%)
		ABC_membrane	98..367	CDD:294371	79/271 (29%)
		ABCC_MRP_domain1	443..643	CDD:213217	87/200 (44%)
		ABC_membrane	799..1027	CDD:294371	74/241 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	123/221 (56%)
ABCC11	NP_001319112.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720