DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC12

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001319111.1	Gene:	ABCC12 / 839921	AraportID:	AT1G30410	Length:	1498	Species:	Arabidopsis thaliana

Alignment Length:	1345	Identity:	468/1345 - (34%)
Similarity:	733/1345 - (54%)	Gaps:	139/1345 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKK 77
            |...::|||.:.|.:..|....|.:|.:.|.|:::..:..:::.|..:....|   .|:.|:.|
plant   228 PERHASIFSRIYFGWITPLMQLGYRKPITEKDVWQLDKWDQTETLIKRFQRCW---TEESRRPK- 288

  Fly    78 TPSLLKASMNVFGWR--LAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYA 140
             |.||:|..|..|.|  |||   :..:..||..::|  |:|.::..:...|.||||.....|:||
plant   289 -PWLLRALNNSLGGRFWLAG---IFKVTRIGNDLSQ--FVGPVILSHLLRSMQEGDPAWVGYVYA 347

  Fly   141 LGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVG 205
            ..:.:.....||....|...::.:|.:.|..:.:.|:.|:|||:..|..:...|:|.|:|:.|..
plant   348 FIIFVGVTLGVLCEAQYFQNVWRVGFRLRSTLVAAIFHKSLRLTHEARKNFASGKVTNMITTDAN 412

  Fly   206 RLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALR 270
            .|......::.||..|..|.:...|:|:::|:::.||..::.|.||||..:..|...|..:....
plant   413 ALQQISQQLHGLWSAPFRIIVSMILLYQQLGVASLFGSLILFLLIPLQTLIISKMRKLTKEGLQW 477

  Fly   271 TDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVF 335
            ||:||.:.|||:|.:..:|.||||..|...|..:|.:|::..|....: ....|||:  ..|.|.
plant   478 TDKRVGITNEILSSMDTVKCYAWEKSFESRIQGIRNEELSWFRKAQLL-SAFNSFIL--NSIPVV 539

  Fly   336 VSLVG---FVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMG-----ISQFAELLVSIRRIQTFM 392
            |::|.   |||||..||..:||...:.:.:||      ||:.     :||.....||::||:..:
plant   540 VTVVSFGVFVLLGGDLTPARAFTSLSLFAVLR------FPLNMLPNLLSQVVNANVSLQRIEELL 598

  Fly   393 LHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNT 457
            |.||.                  ::|:      ...|:|.:       .:|.|......||.|.|
plant   599 LSEER------------------ILAQ------NPPLQPGT-------PAISIKNGYFSWDSKTT 632

  Fly   458 DNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGEL-NPDSGSVKVNGTLSYASQEPWLFTGT 521
            ..||.:|:|:.....|||::|..|.||:|||.|:|||| :.::.||.:.|:::|..|..|:|..|
plant   633 KPTLSDINLEIPVGTLVAIVGGTGEGKTSLISAMLGELSHAETTSVVIRGSVAYVPQVSWIFNAT 697

  Fly   522 VRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKA 586
            ||:|||||...:..||...:...||:.|.:|||..|.|.:||||.::|||||.|:|:|||||..:
plant   698 VRENILFGSDFESERYWRAIDATALQHDLDLLPGRDLTEIGERGVNISGGQKQRVSMARAVYSNS 762

  Fly   587 DIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYE 651
            |:|:.||||||:|.||...:||.||:..||.:..:|||:||.||...|.|:::.:|.|...||:.
plant   763 DVYIFDDPLSALDAHVAHQVFDSCMKDELRGKTRVLVTNQLHFLPLMDKIILVSEGMIKEEGTFV 827

  Fly   652 SMAKSGLDFAQMLTDPSKKDEGAG--DAPDKKSLSRQN-SKLRDRHGSISSMESAAESLAA---- 709
            .::|||:.|.:::       |.||  ||..:.:.:.:| .||    |...:::.:..:|.:
plant   828 ELSKSGILFKKLM-------ENAGKMDATQEVNTNDENILKL----GPTVTVDVSERNLGSTKQG 881

  Fly   710 ---ESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFC--IGAQVLASGGDIFLSYWVNKN 769
               .|.:..||.|..|.|...:..:|..|.| ||::|.....  :..:||......:||.|.:::
plant   882 KRRRSVLIKQEERETGIISWNVLMRYKEAVG-GLWVVMILLACYLATEVLRVSSSTWLSIWTDQS 945

  Fly   770 GEAERDTFMARLRRAFPETRINADTDP---VDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTL 831
                                .:.:..|   :.:|...|.....:.|:  .|......::.::..|
plant   946 --------------------TSKNYSPGFYIVVYALLGFGQVAVTFT--NSFWLITSSLHAARRL 988

  Fly   832 HNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVM---MDVMQIFLAIVGIVVVLCI 893
            |:.|...:.||.|.||:|||:||::||||||:|.:|..:.::|   |:.:...|:...::..:..
plant   989 HDAMLSSILRAPMLFFHTNPTGRVINRFSKDIGDIDRNVANLMNMFMNQLWQLLSTFALIGTVST 1053

  Fly   894 INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELI 958
            |::|.|:.   |:|:||...::|.||||:|:||::|||||||:....:||||::|||:.|. :.:
plant  1054 ISLWAIMP---LLILFYAAYLYYQSTSREVRRLDSVTRSPIYAQFGEALNGLSSIRAYKAY-DRM 1114

  Fly   959 AEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAV---ITLSFFLFSPENG---------GD 1011
            |:. |.:.|.::  ..|...:.:...||.........|   :|.:|.:.  :||         ..
plant  1115 AKI-NGKSMDNN--IRFTLANTSSNRWLTIRLETLGGVMIWLTATFAVL--QNGNTNNQAGFAST 1174

  Fly  1012 VGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKI 1076
            :||.::..:.:|.::...:||::..||::.:||||..|.||..|.. :...|.:|...||..|.|
plant  1175 MGLLLSYTLNITSLLSGVLRQASRAENSLNSVERVGNYIDLPSEAT-DIIENNRPVCGWPSGGSI 1238

  Fly  1077 VFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRR 1140
            .|:|:.|:|.|  ....||..|...:...||||:||||||||||::|||||: ...:|.|:||..
plant  1239 KFEDVHLRYRP--GLPPVLHGLTFFVSPSEKVGVVGRTGAGKSSMLNALFRIVEVEKGRIMIDDC 1301

  Fly  1141 DTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQS 1205
            |....||.|:|..:|||||.|||||||:|:|:|||.|::||.|||:|....:|.|::..|.||.:
plant  1302 DVAKFGLTDVRRVLSIIPQSPVLFSGTVRFNIDPFSEHNDAGLWEALHRAHIKDVISRNPFGLDA 1366

  Fly  1206 KISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAH 1270
            ::.|||.|||||||||:.||||:||.::|||:|||||:||.:||:|||.|||.:||.||:|.|||
plant  1367 EVCEGGENFSVGQRQLLSLARALLRRSKILVLDEATASVDVRTDSLIQRTIREEFKSCTMLVIAH 1431

  Fly  1271 RLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||:|::|.||:||:.:|:.:|:.||.||| :.:...|..||..||
plant  1432 RLNTIIDCDKILVLSSGQVLEYDSPQELL-SRDTSAFFRMVHSTG 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	462/1328 (35%)
		ABC_membrane	98..367	CDD:294371	82/271 (30%)
		ABCC_MRP_domain1	443..643	CDD:213217	92/200 (46%)
		ABC_membrane	799..1027	CDD:294371	72/242 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	121/221 (55%)
ABCC12	NP_001319111.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720