Protein Alignment CG4562 and ABCC5

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_171908.1
• Gene: ABCC5 / 839277
• AraportID: AT1G04120
• Length: 1514
• Species: Arabidopsis thaliana
• Alignment Length: 1365
• Identity: 441/1365 - (32%)
• Similarity: 691/1365 - (50%)
• Gaps: 135/1365 - (9%)

  Fly     9 LPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKR 73
            |...|...:.:.|.:...:..|....|.|:.|:..|:.......|:......|.:.|::  .|..
plant   225 LKVTPYSTAGLVSLITLSWLDPLLSAGSKRPLELKDIPLLAPRDRAKSSYKVLKSNWKR--CKSE 287

  Fly    74 KKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGG-LVAYYADASNQEGDNQTKAY 137
            ...|.|||.:|.|..| |:.|....|...|.     |...::|. |::|:.|....:.....:.|
plant   288 NPSKPPSLARAIMKSF-WKEAACNAVFAGLN-----TLVSYVGPYLISYFVDYLGGKEIFPHEGY 346

  Fly   138 LYALGVILTS-ACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLIS 201
            :.| |:..|| ....:....:.:|:..:||..|.|:|:|:|||.|:||..|..:.|.|::||.::
plant   347 VLA-GIFFTSKLIETVTTRQWYMGVDILGMHVRSALTAMVYRKGLKLSSIAKQNHTSGEIVNYMA 410

  Fly   202 NDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLK 266
            .||.|:.....:::.:|:.|::|.:...::|:.:||:|...:...::.|.:...|.|.....:.|
plant   411 VDVQRIGDYSWYLHDIWMLPMQIVLALAILYKSVGIAAVATLVATIISILVTIPLAKVQEDYQDK 475

  Fly   267 TALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTR 331
            .....|||:|..:|.:..::|:|:.|||..:...:..:|.:|...:|...|    .|:|:.|:..
plant   476 LMTAKDERMRKTSECLRNMRVLKLQAWEDRYRVRLEEMREEEYGWLRKALY----SQAFVTFIFW 536

  Fly   332 IS-VFVSLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFM 392
            .| :||:.|.|   :.||..|||.......|.:.||:..:. .||..:|..|:..||:.||..|:
plant   537 SSPIFVAAVTFATSIFLGTQLTAGGVLSALATFRILQEPLR-NFPDLVSMMAQTKVSLDRISGFL 600

  Fly   393 LHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNT 457
            ..||                   |..:.||....|:    |....|.:..:..      ||..::
plant   601 QEEE-------------------LQEDATVVIPRGL----SNIAIEIKDGVFC------WDPFSS 636

  Fly   458 DNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTV 522
            ..||..|.:|.:....|||.|.|||||||.|..:|||:...||.|::.||..|.||..|:.:|.:
plant   637 RPTLSGIQMKVEKGMRVAVCGTVGSGKSSFISCILGEIPKISGEVRICGTTGYVSQSAWIQSGNI 701

  Fly   523 RQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKAD 587
            .:|||||.||:|.:|:.|::.|:|::|.||..:.|:||:||||.:||||||.|:.||||:|:.||
plant   702 EENILFGSPMEKTKYKNVIQACSLKKDIELFSHGDQTIIGERGINLSGGQKQRVQLARALYQDAD 766

  Fly   588 IYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES 652
            |||||||.||:|.|.|..||...:...|.|:.|:.||||::||..||:|:::.:|:|...|.|:.
plant   767 IYLLDDPFSALDAHTGSDLFRDYILSALAEKTVVFVTHQVEFLPAADLILVLKEGRIIQSGKYDD 831

  Fly   653 MAKSGLDFAQMLTD----------PSKKDEGAGDAPDKKSLSRQN-------------SKLRDRH 694
            :.::|.||..:::.          ||...|.:.:.|.:.||...|             :|.....
plant   832 LLQAGTDFKALVSAHHEAIEAMDIPSPSSEDSDENPIRDSLVLHNPKSDVFENDIETLAKEVQEG 896

  Fly   695 GSISSMESAAE-----SLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVL 754
            ||.|.:::..|     ..:.:..:..:|.||:|::.||:|..|.||...|..|...       :|
plant   897 GSASDLKAIKEKKKKAKRSRKKQLVQEEERVKGKVSMKVYLSYMGAAYKGALIPLI-------IL 954

  Fly   755 ASGGDIFL----SYWVNKNGEAERDTFMARLRRAFPETRINADTDPVD----IYYFTGINVSVII 811
            |.....||    ::|:                 |:...:...|...||    :..:|.:.....:
plant   955 AQAAFQFLQIASNWWM-----------------AWANPQTEGDESKVDPTLLLIVYTALAFGSSV 1002

  Fly   812 FSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMD 876
            |..||:.|.....:.::..|...|.:.|.||.|.||::.|:||||||.|.|...||..:|..:..
plant  1003 FIFVRAALVATFGLAAAQKLFLNMLRSVFRAPMSFFDSTPAGRILNRVSIDQSVVDLDIPFRLGG 1067

  Fly   877 VMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSAS 941
            .....:.:.|||.|:..:.....|..|.:.:..:.::.:|:::||::.|:.::.:|||......|
plant  1068 FASTTIQLCGIVAVMTNVTWQVFLLVVPVAVACFWMQKYYMASSRELVRIVSIQKSPIIHLFGES 1132

  Fly   942 LNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSF---FL 1003
            :.|.||||.||.:|..|.......|.....::..:|...    || |:.:..::.:..:|   .|
plant  1133 IAGAATIRGFGQEKRFIKRNLYLLDCFVRPFFCSIAAIE----WL-CLRMELLSTLVFAFCMVLL 1192

  Fly  1004 FSPENG----GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEG-----DFE 1059
            .|..:|    ...|||:|..:.:.|.:...:....:|||.:.::||:.:|..:..|.     ||
plant  1193 VSFPHGTIDPSMAGLAVTYGLNLNGRLSRWILSFCKLENKIISIERIYQYSQIVGEAPAIIEDF- 1256

  Fly  1060 SKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINA 1124
                 :||..||..|.|...|:.::|..:...  ||..::....|.:|:|||||||:|||:||.|
plant  1257 -----RPPSSWPATGTIELVDVKVRYAENLPT--VLHGVSCVFPGGKKIGIVGRTGSGKSTLIQA 1314

  Fly  1125 LFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLE 1188
            |||| ....|.|.||..|.:.:|||||||::.||||:|.||.||:|.||||.:|:||.|:||:|:
plant  1315 LFRLIEPTAGKITIDNIDISQIGLHDLRSRLGIIPQDPTLFEGTIRANLDPLEEHSDDKIWEALD 1379

  Fly  1189 EVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQ 1253
            :.:|..||......|.|.:.|.|.|:||||||||.|.||:|::.:|||:|||||:||..||.|||
plant  1380 KSQLGDVVRGKDLKLDSPVLENGDNWSVGQRQLVSLGRALLKQAKILVLDEATASVDTATDNLIQ 1444

  Fly  1254 TTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDST 1318
            ..||.:|:||||.|||||:.||:|||.|||:..|:..||.:|..||..........:.:.:..||
plant  1445 KIIRTEFEDCTVCTIAHRIPTVIDSDLVLVLSDGRVAEFDTPARLLEDKSSMFLKLVTEYSSRST 1509

  Fly  1319  1318
            plant  1510  1509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	437/1342 (33%)
		ABC_membrane	98..367	CDD:294371	74/274 (27%)
		ABCC_MRP_domain1	443..643	CDD:213217	93/199 (47%)
		ABC_membrane	799..1027	CDD:294371	62/234 (26%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	116/221 (52%)
ABCC5	NP_171908.1	MRP_assoc_pro	229..1493	CDD:188098	438/1343 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720