DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and PGP10

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_172538.1	Gene:	PGP10 / 837611	AraportID:	AT1G10680	Length:	1227	Species:	Arabidopsis thaliana

Alignment Length:	1432	Identity:	310/1432 - (21%)
Similarity:	574/1432 - (40%)	Gaps:	388/1432 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 AAWEKEVEKKRKKKKTPSLLK------------ASMNVFGWRLAGLGLVLFILEIGFRVTQPLFL 115
            ||.|||     ||:.:.|.||            .::...|..:.|..:.:|.:..|..:.    :
plant    13 AAAEKE-----KKRPSVSFLKLFSFADFYDCVLMALGSIGACIHGASVPVFFIFFGKLIN----I 68

  Fly   116 GGLVAYYADASNQEGDNQTKAYLYALGVILTS-----ACNVLFMHPYMLGMFHIGMKARIAMTSM 175
            .||...:...::.:....:..::|...|||.|     ||           ..|.| :.:.|....
plant    69 IGLAYLFPQEASHKVAKYSLDFVYLSVVILFSSWLEVAC-----------WMHTG-ERQAAKIRK 121

  Fly   176 IYRKALRLSRTALGDTTI--GQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYR----- 233
            .|.:::.....:|.||.|  |:|::.|::::..:..::..         ::|...:.:.|
plant   122 AYLRSMLSQDISLFDTEISTGEVISAITSEILVVQDAISE---------KVGNFMHFISRFIAGF 177

  Fly   234 EIGISAFFGVAVMLL----FIPL----QAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKM 290
            .||.::.:.::::.|    ||.|    .|::.....|...|:.::.:|   :..|:|..::.::.
plant   178 AIGFASVWQISLVTLSIVPFIALAGGIYAFVSSGLIVRVRKSYVKANE---IAEEVIGNVRTVQA 239

  Fly   291 YAWEIPFSKMINYVRTKEMNAIRNV-NYIR----------GTLQSFIMFVT--RISVFVSLV--- 339
            :..|   .|.:    :....|:||. ||.|          |:|. |::|::  .:..|.|:|
plant   240 FTGE---EKAV----SSYQGALRNTYNYGRKAGLAKGLGLGSLH-FVLFLSWALLIWFTSIVVHK 296

  Fly   340 GFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEET------K 398
            |....|:..|.....||..              :.:.|.|.      .|.|||.....      .
plant   297 GIANGGESFTTMLNVVIAG--------------LSLGQAAP------DISTFMRASAAAYPIFQM 341

  Fly   399 VRDKSEDLDEQKLGKAG---LIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNT 460
            :...:||...:|||...   |..:.|.             |..:...:||
plant   342 IERNTEDKTGRKLGNVNGDILFKDVTF-------------TYPSRPDVVI--------------- 378

  Fly   461 LDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGT-------------LSYAS 512
            .|.::......::||::|..|||||::|..:.....|..|:|.::|.             :...:
plant   379 FDKLNFVIPAGKVVALVGGSGSGKSTMISLIERFYEPTDGAVMLDGNDIRYLDLKWLRGHIGLVN 443

  Fly   513 QEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFEL---LPYADKTIVGERGASLSGGQKA 574
            |||.||..|:|:||::|  .|......:.....|......   ||...:|.|||||..||||||.
plant   444 QEPVLFATTIRENIMYG--KDDATSEEITNAAKLSEAISFINNLPEGFETQVGERGIQLSGGQKQ 506

  Fly   575 RISLARAVYRKADIYLLDDPLSAVDTH---VGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVI 636
            |||::||:.:...|.|||:..||:|..   :.:...|:.|.|    ...::|.|:|..:..||:|
plant   507 RISISRAIVKNPSILLLDEATSALDAESEKIVQEALDRVMVG----RTTVVVAHRLSTVRNADII 567

  Fly   637 VIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSME 701
            .::..|||...|:::          :::::|    :||     ..||.|.............|:.
plant   568 AVVGGGKIIESGSHD----------ELISNP----DGA-----YSSLLRIQEAASPNLNHTPSLP 613

  Fly   702 SAAESL--------------AAESPMQTQEGRVEGRIGMKLYK------KYFGANGYGLFIV--- 743
            .:.:.|              :...|..|::.:|  .:| :||.      ||......|.||.
plant   614 VSTKPLPELPITETTSSIHQSVNQPDTTKQAKV--TVG-RLYSMIRPDWKYGLCGTLGSFIAGSQ 675

  Fly   744 FAFFCIG-AQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINV 807
            ...|.:| ||.|.|    :...|.....|.:|                      :.|.:..|..:
plant   676 MPLFALGIAQALVS----YYMDWETTQNEVKR----------------------ISILFCCGSVI 714

  Fly   808 SVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFN--TNPSGRILNRFSKDLGQVDEIL 870
            :||:.: :....|..:..|.:..:...||..:.|..:.:|:  .|.|..:.:|...|.    .:|
plant   715 TVIVHT-IEHTTFGIMGERLTLRVRQKMFSAILRNEIGWFDKVDNTSSMLASRLESDA----TLL 774

  Fly   871 PSVMMDVMQIFLAIVGIVVVLCIINV---W----YILATVFLVIVFYLL-RVFYLSTSRDVKRLE 927
            .::::|...|.|..:|:||...||:.   |    .:|||..|:|..::. ::|......::.:
plant   775 RTIVVDRSTILLENLGLVVTAFIISFILNWRLTLVVLATYPLIISGHISEKIFMQGYGGNLSK-- 837

  Fly   928 AVTRSPIYSHLSA------SLNGLATIRAFGAQKELIAEFDNYQDMHS----------------- 969
                    ::|.|      |::.:.|:.||.|:::::       |::|
plant   838 --------AYLKANMLAGESISNIRTVVAFCAEEKVL-------DLYSKELLEPSERSFRRGQMA 887

  Fly   970 ------SGYYMFLATSRAFGYW----------LDCVCVVYIAVITLSFFL-----FSPE--NGGD 1011
                  |.:::|.:...|..|.          .:.|...::.:|..:..:     .:|:  .|..
plant   888 GILYGVSQFFIFSSYGLALWYGSILMEKGLSSFESVMKTFMVLIVTALVMGEVLALAPDLLKGNQ 952

  Fly  1012 VGLAI-------TQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKD 1069
            :.:::       ||.:|.||         .||.|    ||..:|.:.:  ...:.|:|:
plant   953 MVVSVFELLDRRTQVVGDTG---------EELSN----VEGTIELKGV--HFSYPSRPD------ 996

  Fly  1070 WPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYN--E 1132
                 ..:|.|                 .|:.:...:.:.:||::|:||||:::.:.|. |:  .
plant   997 -----VTIFSD-----------------FNLLVPSGKSMALVGQSGSGKSSVLSLVLRF-YDPTA 1038

  Fly  1133 GAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYN-LDPFDEYSDAKLWESLEEVKLKQVV 1196
            |.|:||.:|...|.|..||..|.::.|||.||:.|:..| |...:..|::::.|:.:.......:
plant  1039 GIIMIDGQDIKKLKLKSLRRHIGLVQQEPALFATTIYENILYGKEGASESEVMEAAKLANAHSFI 1103

  Fly  1197 ADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFK 1261
            :.||.|..:|:.|.|...|.||||.:.:|||:|:...||::||||:.:|.:::.::|..:....:
plant  1104 SSLPEGYSTKVGERGIQMSGGQRQRIAIARAVLKNPEILLLDEATSALDVESERVVQQALDRLMR 1168

  Fly  1262 DCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVA 1326
            |.|.:.:||||.|:.:||.:.|:..||.:|.||             |:::.:..:..:..|:.:.
plant  1169 DRTTVVVAHRLSTIKNSDMISVIQDGKIIEQGS-------------HNILVENKNGPYSKLISLQ 1220

  Fly  1327 QK 1328
            |:
plant  1221 QR 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	307/1402 (22%)
		ABC_membrane	98..367	CDD:294371	56/304 (18%)
		ABCC_MRP_domain1	443..643	CDD:213217	63/218 (29%)
		ABC_membrane	799..1027	CDD:294371	52/290 (18%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	69/223 (31%)
PGP10	NP_172538.1	PTZ00265	40..1221	CDD:240339	299/1397 (21%)
		ABC_membrane	50..313	CDD:279056	55/298 (18%)
		ABC_MTABC3_MDL1_MDL2	361..599	CDD:213216	76/290 (26%)
		ABC_membrane	666..935	CDD:279056	57/316 (18%)
		ABC_MTABC3_MDL1_MDL2	982..1220	CDD:213216	75/281 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910