DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC9

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_191575.2	Gene:	ABCC9 / 825186	AraportID:	AT3G60160	Length:	1506	Species:	Arabidopsis thaliana

Alignment Length:	1386	Identity:	438/1386 - (31%)
Similarity:	697/1386 - (50%)	Gaps:	184/1386 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSA--- 63
            |:.|......:|...:.:|..:.|.:..|.|..|.|:.|:::|:         ..:..|.||
plant   225 QNKKDSYSSSSPYGNATLFQRITFSWINPLFSLGYKRPLEKDDV---------PDIDVKDSARFC 280

  Fly    64 --AWEKEVEKKRKKKKTP-------SLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLV 119
              |::::: |..|:|:.|       |:|:     :.||.|.:..|..::........|..:...|
plant   281 SHAFDQKL-KTTKEKEGPGNAFFYNSVLR-----YVWRKAAINAVFAVVNASTAYIGPYLINDFV 339

  Fly   120 AYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLS 184
            .:.::..:|   :....||.|||.:.......:....::.|...:|::.|.|:.|.||:|.|.||
plant   340 EFLSEKQSQ---SLNHGYLLALGFLTAKIVETVTQRQWIFGARQLGLRLRAALISHIYQKGLVLS 401

  Fly   185 RTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLF 249
            ..:....|.|:::|.:|.||.|:...:.::|.:|:.|::|....|::.:.:|:.|...:...|:.
plant   402 SQSRQSHTSGEIINYMSVDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLMV 466

  Fly   250 IPLQAYLGK-----KTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEM 309
            :.....|.:     ::.::..|     |:|::..:||:..::::|:.||:..|...:..:|.||.
plant   467 MACNYPLTRLQRNYQSDIMNAK-----DDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEY 526

  Fly   310 NAI-RNVNYIRGTLQSFIMFV-----TRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMT 368
            :.: :::.     ||:|..|:     :.||| |:.|..:|:|..|||.......|.:.:|::.:
plant   527 DCLWKSLR-----LQAFTTFILWGAPSLISV-VTFVTCMLMGVKLTAGAVLSALATFQMLQSPI- 584

  Fly   369 VYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSS 433
            ...|..:|...:..||..||.:::...||: :|..|...:
plant   585 FGLPDLLSALVQSKVSADRIASYLQQSETQ-KDAVEYCSK------------------------- 623

  Fly   434 RRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPD 498
               ...|.|:.|......|:.:::..|||:|.||.|....|||.|.||||||||:.::|||:...
plant   624 ---DHTELSVEIENGAFSWEPESSRPTLDDIELKVKSGMKVAVCGAVGSGKSSLLSSILGEIQKL 685

  Fly   499 SGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGE 563
            .|:|:|:|..:|..|.||:.:||:|.|||||...:..:|...||.|||.:||||....|.|.:||
plant   686 KGTVRVSGKQAYVPQSPWILSGTIRDNILFGSMYESEKYERTVKACALIKDFELFSNGDLTEIGE 750

  Fly   564 RGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQ 628
            ||.::|||||.||.:|||||:.|||||||||.||||.|.||.||:.|:.|.|:::.||.||||::
plant   751 RGINMSGGQKQRIQIARAVYQNADIYLLDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVE 815

  Fly   629 FLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDR 693
            ||..||:|::|..|::...|.:|.:.|..:.|..::        ||.:......||.:.|....:
plant   816 FLPAADLILVMQNGRVMQAGKFEELLKQNIGFEVLV--------GAHNEALDSILSIEKSSRNFK 872

  Fly   694 HGSISSMESAAESLAA---------------ESPMQTQEGRVEGRIGMKLYKKYFGANGYGL--- 740
            .||.....|.||||..               |:.:...|...:|.||.::|..|......||
plant   873 EGSKDDTASIAESLQTHCDSEHNISTENKKKEAKLVQDEETEKGVIGKEVYLAYLTTVKGGLLVP 937

  Fly   741 FIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGI 805
            ||:.|..|.  |:|....:.::::......|:.....|.|:               :.:|.....
plant   938 FIILAQSCF--QMLQIASNYWMAWTAPPTAESIPKLGMGRI---------------LLVYALLAA 985

  Fly   806 NVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVD-EI 869
            ..|:.:  |.|::|.....:.::.|..:.|...:.||.|.||::.|:||||||.|.|...:| |:
plant   986 GSSLCV--LARTILVAIGGLSTAETFFSRMLCSIFRAPMSFFDSTPTGRILNRASTDQSVLDLEM 1048

  Fly   870 LPSVMMDVMQIFLAIVGIVVVLCII--NVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRS 932
            ...:......| :.|||.:.|:..:  .|..|...|.:..|||  :.:|..|:|::.|:..|.|:
plant  1049 AVKLGWCAFSI-IQIVGTIFVMSQVAWQVCVIFIPVAVACVFY--QRYYTPTARELSRMSGVERA 1110

  Fly   933 PIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVI 997
            ||..|.:.||.|..|||||..:...|:......|.||..::...:...    ||.      ..:.
plant  1111 PILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFHVASAME----WLS------FRLN 1165

  Fly   998 TLSFFLFS---------PE---NGGDVGLAITQAMGMT---GMVQWGMRQSAELENTMTAVERVV 1047
            .||.|:|:         ||   |....||.:|..:.:.   ..|.|.:   ...||.|.:|||::
plant  1166 LLSHFVFAFSLVLLVTLPEGVINPSIAGLGVTYGLSLNVLQATVIWNI---CNAENKMISVERIL 1227

  Fly  1048 EYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKY---FPDKAADYVLRSLNIAIEGCEKVG 1109
            :|..:..|..... ...:|..:||..|.|||.||.::|   ||     .||:::.....|.:|:|
plant  1228 QYSKIPSEAPLVI-DGHRPLDNWPNVGSIVFRDLQVRYAEHFP-----AVLKNITCEFPGGKKIG 1286

  Fly  1110 IVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLD 1173
            :|||||:|||:||.||||: ..::|.|:||..|...:|||||||::.||||:|.||.||:|.|||
plant  1287 VVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLGIIPQDPALFDGTIRLNLD 1351

  Fly  1174 PFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMD 1238
            |..:|:|.::||::::.:|..|:......|.:.:.|.|.|:||||||||||.|.:|:::.|||:|
plant  1352 PLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVGQRQLVCLGRVLLKKSNILVLD 1416

  Fly  1239 EATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSE 1303
            ||||:||..||.:||..|..:|||.||:|||||:|||::||.|||:..|:..||.||.:||
plant  1417 EATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGRIAEFDSPAKLL---- 1477

  Fly  1304 KKVFHSMVKQTGDSTFDALLK 1324
                     |..||.|..|:|
plant  1478 ---------QREDSFFSKLIK 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	429/1350 (32%)
		ABC_membrane	98..367	CDD:294371	64/279 (23%)
		ABCC_MRP_domain1	443..643	CDD:213217	101/199 (51%)
		ABC_membrane	799..1027	CDD:294371	67/245 (27%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	112/224 (50%)
ABCC9	NP_191575.2	PLN03232	68..1488	CDD:215640	436/1383 (32%)
		ABC_membrane	319..586	CDD:294371	64/281 (23%)
		ABCC_MRP_domain1	630..830	CDD:213217	101/199 (51%)
		ABC_membrane	973..1209	CDD:294371	69/265 (26%)
		ABCC_MRP_domain2	1253..1473	CDD:213211	112/224 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720