DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCA5

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001326002.1	Gene:	ABCA5 / 823930	AraportID:	AT3G47760	Length:	936	Species:	Arabidopsis thaliana

Alignment Length:	702	Identity:	142/702 - (20%)
Similarity:	249/702 - (35%)	Gaps:	210/702 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 LSYWVNKNGEAERDTF----MARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSL----VRSM 818
            |:.|.|.:.|...:.|    ...|.....|.....|....||..|   ||::...|.    :|..
plant   230 LNLWRNNSIEISNEIFKGYRQGNLEEIINEVAAAYDLMDTDINNF---NVTIWYNSTYKGDLRDR 291

  Fly   819 LFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDE--------------- 868
            ...|:.:..|..|       |:.|.:.|...:.: ::|..|.|::.:.:.
plant   292 RVKYVRVPRSVNL-------VSNAYLEFLQGSGT-KMLFDFVKEMPKQETRLRLEMASLIGPIFF 348

  Fly   869 ----------ILPSVMMDVMQ----------------------IFLAIVGIVVVLCIINVWYILA 901
                      :|.|::.:..|                      .|||| .||.::|::.....:.
plant   349 TWVILLLFPVMLTSLVYEKQQHLRIIMKMHGLGDGPYWMITYAYFLAI-SIVYIICLMIFGSAIG 412

  Fly   902 TVF-------LVIVFYLLRV-------FYLSTSRDVKRLEAVTRSPIYSHLSAS----------- 941
            ..|       :..:||.|.:       |.:|::  ..::|..:.: .|.::..|
plant   413 LKFFRFNDYSIQFIFYFLCINLQISIAFLVSSA--FSKIETASVA-AYLYVFGSGLLGAFLFQFL 474

  Fly   942 LNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFG--YWLD----------CVCVV-- 992
            |.||:..|::....||...|..|:.::....|.|.......|  .|.|          .:.:|
plant   475 LEGLSFPRSWIYIMELYPGFSLYRGLYEFSQYAFKRNLNGSGGMKWKDFNDSAMEEIFYIIIVEW 539

  Fly   993 YIAVITL------------SFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVER 1045
            ::|:|..            .||....:|      ...::....|:.:.....:.|:|....|.||
plant   540 FVALIAAYYTDKISSSGIDPFFFLKNQN------PFKKSPSPYGLQRQVSAIAIEMEKLDVAHER 598

  Fly  1046 V-VEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKY-----FPDKAADYVLRSLNIAIEG 1104
            | ||...||..                ....||.|:|...|     .|.|.|   :|.|::|:..
plant   599 VKVEQLMLETS----------------TGHAIVCDNLKKVYPCRDGNPQKMA---VRGLSLAVPS 644

  Fly  1105 CEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRD-TNDLGLHDLRSKISIIPQ-------- 1159
            .|..|::|..||||:|.||.:..| ....||..:...| ..|:.:  :.:.|.:.||
plant   645 GECFGMLGPNGAGKTSFINMMTGLMKPTSGAAFVHGLDICKDMDI--VYTSIGVCPQHDLLWETL 707

  Fly  1160 ---EPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKL-KQVVADLPSGLQSKISEGGTNFSVGQRQ 1220
               |.:||.|.:: ||...|  .|..:.|||:.|.| :..|||.|:|          .:|.|.::
plant   708 TGREHLLFYGRLK-NLKGSD--LDQAVEESLKSVNLFRGGVADKPAG----------KYSGGMKR 759

  Fly  1221 LVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV-MDSDKVLVM 1284
            .:.:|.:::...:::.|||.:..:||.:...:.|.|:.......::...|.:... ...|::.:.
plant   760 RLSVAISLIGSPKVVYMDEPSTGLDPASRRSLWTAIKRAKNHTAIILTTHSMEEAEFLCDRLGIF 824

  Fly  1285 DAGKAVEFGSPFEL-----------LTT-----------------SEKKVFH 1308
            ..|:....|:|.||           :||                 :.||::|
plant   825 VDGRLQCVGNPKELKARYGGSYVLTMTTPSEHEKDVEMLVQDVSPNAKKIYH 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	137/675 (20%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	54/329 (16%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	61/240 (25%)
ABCA5	NP_001326002.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910