DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCA3

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_190358.3	Gene:	ABCA3 / 823928	AraportID:	AT3G47740	Length:	932	Species:	Arabidopsis thaliana

Alignment Length:	910	Identity:	175/910 - (19%)
Similarity:	318/910 - (34%)	Gaps:	261/910 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 ISLARAVYRKADIYLLDD--------PLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQ 632
            |.:.|..||..|....:|        |::.:.|.....|.....|..||....         :..
plant   106 ILIPRPEYRALDANFTNDSCRRKNSCPVTILFTGNNHSLGAVLSRNLLRRPFA---------MNS 161

  Fly   633 ADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSI 697
            :|::..:....::.  |::..|.:.||              ||...|....:.|.....:.:.||
plant   162 SDLLFSLANNVLAT--TFKGSATNYLD--------------AGIVSDGSIYNIQPRCPPNSNFSI 210

  Fly   698 SSMESAAESLAAESPMQ-TQEGR-VEG---------RIGMKLYKKYFGANGYGLF--IVFAFFCI 749
            |         ..:||:. |::.| |:|         .:.::|::.|...|..|:.  ||.|:
plant   211 S---------IGQSPLNFTKDMRCVQGLNLWRNNSIEVNLELFEGYHKGNSDGMINEIVAAY--- 263

  Fly   750 GAQVLASGGDIF--------LSYWVNK--NGEAERDTFMA---------------------RLRR 783
                     |:|        ::.|.|.  ..||....:..                     |.:.
plant   264 ---------DLFDTNMTNFNVNIWFNATYKDEARNQPYKVVRVPRLVNWVSNAYLQYLQGPRTKM 319

  Fly   784 AF--------PETRINADTDPVDIYYFTGINVSVIIFSLVRSMLF-FYLAMRSSTTLHNTMFQGV 839
            .|        |||::..|                 |.||:..:.| :.:.:.....|::.:::..
plant   320 LFEFVKEMPKPETKLRLD-----------------IASLIGPIFFTWVILLLLPVILNSLVYEKQ 367

  Fly   840 TR----AAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVL--CIINVWY 898
            .|    ..||.....|...|...:...|.           ....|||.|.|.|:.|  .::|.:.
plant   368 QRLRIIMKMHGLGDGPYWIISYAYFLALS-----------TFYIIFLMIFGSVIGLKFFLLNDFS 421

  Fly   899 ILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSA---------SLNGLATIRAFGAQ 954
            :..:.:.|.:...:.:.:|.:|...|...|...:.:|...|.         .|.||:..|.:...
plant   422 LQFSFYFVYINLQISIAFLLSSAFSKVETASVAAYLYVFGSGLLGMFLFQFLLEGLSFPRRWIFV 486

  Fly   955 KELIAEFDNYQDMH--SSGYYMFLATSRAFGYW-------LDCVCVV-----YIAVITLSFFLFS 1005
            .||...|..|:.::  |...|......:....|       :|.|..:     ::|:|...:....
plant   487 MELYPGFSLYRGLYEFSQNAYQGNLNGKDGMKWKYFSDNAIDEVFYIIIVEWFVALIATYYIDKM 551

  Fly  1006 PENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGD------FESKPNK 1064
            ..:|.|:...:..        |...:.|..|:..::|:...:|..|:..|.:      .||..:.
plant   552 SSSGKDLLFFLKN--------QNPFKISHSLQKQVSAISVEMEKLDVIHESEKVAQLMLESSTSH 608

  Fly  1065 KPPKDWPEDGKIVFDDLSLKYFPDKAAD---YVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALF 1126
                      .||.|.|. |.:|.:..:   ..:|.|::|:...|..|::|..||||:|.||.:.
plant   609 ----------AIVCDKLR-KVYPGRDGNPPKKAVRVLSLAVPSGECFGMLGPNGAGKTSFINMMT 662

  Fly  1127 RL-SYNEGAILIDRRDT--------NDLGL---HDLRSKISIIPQEPVLFSGTMRYNLDPFDEYS 1179
            .| ....||..:...|.        ..:|:   |||..: ::..:|.:||.|.:: ||...|  .
plant   663 GLVKPTSGAAFVQGLDICKDMDRVYTSMGVCPQHDLLWE-TLTGREHLLFYGRLK-NLKGVD--L 723

  Fly  1180 DAKLWESLEEVKL-KQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATAN 1243
            :..:.|||..|.| ...|||.|:|          .:|.|.::.:.:|.:::...:::.|||.:..
plant   724 NQAVEESLRSVNLFHGGVADKPAG----------KYSGGMKRRLSVAISLIGNPKVVYMDEPSTG 778

  Fly  1244 VDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV-MDSDKVLVMDAGKAVEFGSPFEL--------- 1298
            :||.:...:.|.|:|..:...::...|.:... ...|::.:...|:....|:|.||
plant   779 LDPASRKNLWTVIKNAKRHTAIILTTHSMEEAEFLCDRLGIFVDGRLQCIGNPKELKGRYGGSYV 843

  Fly  1299 --LTTSE-----------------KKVFHSMVKQTGDSTFD---------ALLKVAQKVGLRFKI 1335
              :|||.                 ||::|.    .|...|:         .:.:|.:|....||:
plant   844 LTMTTSSEHEKDVEMLVQEVSPNVKKIYHI----AGTQKFEIPKDEVRISEVFQVVEKAKSNFKV 904

Fly 1336 1335
plant 905 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	163/847 (19%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217	13/74 (18%)
		ABC_membrane	799..1027	CDD:294371	43/257 (17%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	59/237 (25%)
ABCA3	NP_190358.3	ABC2_membrane_3	<360..511	CDD:289468	31/161 (19%)
		CcmA	609..892	CDD:224054	70/301 (23%)
		ABC_subfamily_A	614..835	CDD:213230	58/235 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910