DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC8

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001326629.1	Gene:	ABCC8 / 821679	AraportID:	AT3G21250	Length:	1470	Species:	Arabidopsis thaliana

Alignment Length:	1359	Identity:	434/1359 - (31%)
Similarity:	689/1359 - (50%)	Gaps:	147/1359 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPENPREKS------NIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEK 67
            |.:|||::|      ..||.|.|.:..|....|.||.|...|:...:.|..:.....|.|.||:.
plant   198 LTKNPRKESARLATAGFFSILSFSWMNPLLSLGFKKPLSPEDIPSVVPEDEAQLAYKKFSQAWDT 262

  Fly    68 EVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDN 132
            .:..:...|:...:.:|.:.|:......:.:..|:..... |:.||.|...|.|   |::...|.
plant   263 LLGDESSTKERNLVFRAVVKVYFKENIFIAVFAFLRTFAV-VSLPLMLYVFVDY---ANSDHRDL 323

  Fly   133 QTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVV 197
            :...:..|..|:|....::...|.|.... ..||:.|.|:....|:|.|:||.......:.|::|
plant   324 RNGFFNLACLVMLKLVESLTMRHWYFASR-RSGMRIRSALMVAAYKKQLKLSSLGRKRHSSGEIV 387

  Fly   198 NLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSV 262
            |.|:.|..|:...:...:..|...:::.:.|.:::..:|..||.|:.::||...|.....|....
plant   388 NYIAVDAYRMGEFLWWFHSGWSLSLQLLLSTAVLFGVVGAGAFPGLILLLLCGLLNLPFAKMLQN 452

  Fly   263 LRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFI- 326
            .:.:..:..|:|:|..:||::.::|||:.:||..|.|.|...|..|...:......: ...||:
plant   453 CQTQFMIAQDKRLRSTSEILNSMKVIKLQSWEDEFKKKIESCRDDEFTWLAKAQLTK-AFGSFLY 516

  Fly   327 -MFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQT 390
             |..|.:|..|.|...:|....|.|...|.:.|...::...:.: .|..||...:..||.:|:..
plant   517 WMSPTIVSSVVFLGCALLKSAPLNASTIFTVLATLRVMSEPVKI-IPDAISAIIQGNVSFQRLNN 580

  Fly   391 FMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQK 455
            |:|.:|.|       :||  :.::||.|..|                    ::.|......|:.:
plant   581 FLLDDELK-------MDE--IERSGLDASGT--------------------AVDIQVGNFGWEPE 616

  Fly   456 NTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTG 520
            ....||.||.|:.|..|.|||.||||:|||||:.|||||:...||:|||.|:::|.||..|:.:|
plant   617 TKIPTLRNIHLEIKHGQKVAVCGPVGAGKSSLLHAVLGEIPKVSGTVKVFGSIAYVSQTSWIQSG 681

  Fly   521 TVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRK 585
            |:|.|||:|.||:..||...:|.|||::|.....:.|.|.:|:||.:||||||.||.||||||..
plant   682 TIRDNILYGKPMESRRYNAAIKACALDKDMNGFGHGDLTEIGQRGINLSGGQKQRIQLARAVYAD 746

  Fly   586 ADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY 650
            ||:||||||.||||.|....||.:|:...|:|:.|:|||||::||.:.|.|::|::|.|:..|.|
plant   747 ADVYLLDDPFSAVDAHTAGVLFHKCVEDSLKEKTVILVTHQVEFLSEVDQILVMEEGTITQSGKY 811

  Fly   651 ESMAKSGLDFAQMLTD--------PSKKDEGAGDAPDKKSLSRQNSKLRDRHGS--ISSMESAAE 705
            |.:...|..|.|::..        |...:|..||.       |:..|.|:....  :..:|...|
plant   812 EELLMMGTAFQQLVNAHNDAVTVLPLASNESLGDL-------RKEGKDREIRNMTVVEKIEEEIE 869

  Fly   706 SLAAESPMQTQEGRVE-GRIGMKLYKKYFG-ANGYGLFIVFAFFCIGAQVLASGGDIFL----SY 764
            .........|||...| |.:|||.:..|.| :.|:.|        :.:.||...|.:..    :|
plant   870 KTDIPGVQLTQEEEKESGYVGMKPFLDYIGVSRGWCL--------LWSSVLGQVGFVVFQAASTY 926

  Fly   765 WVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVI-IFSLVRSMLFFYLAMRSS 828
            |:                 ||          .:.|...|  |..:| ::|::.::...::..|:.
plant   927 WL-----------------AF----------AIGIPKIT--NTMLIGVYSIISTLSAGFVYARAI 962

  Fly   829 TTLH------NTMFQGVT----RAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLA 883
            ||.|      ...|.|.|    :|.|.||::.|.||||.|.|.||..:|..:|...:.|:...:.
plant   963 TTAHLGLKASKAFFSGFTNAVFKAPMLFFDSTPVGRILTRASSDLNVLDYDVPFAFIFVVAPAVE 1027

  Fly   884 IVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATI 948
            :...::::..:....|:..:..:....:::.:||:::|::.|:...|::|:.::.:.:..|:.||
plant  1028 LTAALLIMTYVTWQVIIIALLALAATKVVQDYYLASARELIRINGTTKAPVMNYAAETSLGVVTI 1092

  Fly   949 RAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYW--LDCVCVVYIAVITLSFFLFSPENG-- 1009
            ||||..:..   |.||.::..:...:|..::.|. .|  |....:..:.:.|.:..|.....|
plant  1093 RAFGTAERF---FKNYLNLVDADAVLFFLSNAAM-EWVILRIETLQNVTLFTCALLLILIPKGYI 1153

  Fly  1010 --GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDL--EPEGDFESKPNKKPPKDW 1070
              |.|||:::.|:.:|....:..|....|.|::.:|||:.:|.::  ||....:   :|:||..|
plant  1154 APGLVGLSLSYALTLTQTQVFLTRWYCTLSNSIISVERIKQYMNIPEEPPAIID---DKRPPSSW 1215

  Fly  1071 PEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGA 1134
            |.:|.|...:|.::|.|:  |..||:.::.......:||:|||||:|||:||:||||| ....|.
plant  1216 PSNGTIHLQELKIRYRPN--APLVLKGISCTFREGTRVGVVGRTGSGKSTLISALFRLVEPASGC 1278

  Fly  1135 ILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADL 1199
            ||||..|.:.:||.|||.|:|||||||.||.|.:|.||||...|||.::|::||:.:||..:::|
plant  1279 ILIDGIDISKIGLKDLRMKLSIIPQEPTLFRGCIRTNLDPLGVYSDDEIWKALEKCQLKTTISNL 1343

  Fly  1200 PSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCT 1264
            |:.|.|.:|:.|.|:|||||||.||.|.:|:.|:|||:|||||::|..|||:||..||.:|.|||
plant  1344 PNKLDSSVSDEGENWSVGQRQLFCLGRVLLKRNKILVLDEATASIDSATDAIIQRIIREEFADCT 1408

  Fly  1265 VLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALL 1323
            |:|:|||:.||:|||.|:|:..|..||:..|.:|:.|              ||.|..|:
plant  1409 VITVAHRVPTVIDSDMVMVLSFGDLVEYNEPSKLMET--------------DSYFSKLV 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	428/1331 (32%)
		ABC_membrane	98..367	CDD:294371	66/270 (24%)
		ABCC_MRP_domain1	443..643	CDD:213217	100/199 (50%)
		ABC_membrane	799..1027	CDD:294371	58/244 (24%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	114/221 (52%)
ABCC8	NP_001326629.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720