DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC6

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_187916.3	Gene:	ABCC6 / 820497	AraportID:	AT3G13090	Length:	1466	Species:	Arabidopsis thaliana

Alignment Length:	1375	Identity:	451/1375 - (32%)
Similarity:	701/1375 - (50%)	Gaps:	202/1375 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAW----EKEVEKKR 73
            |..|:.|.|.:.|.:..|....|.:|.:|..|:   .|..|||   :..|..|    :.|.:...
plant   208 PFSKAGILSRMSFSWMSPLITLGNEKIIDIKDV---PQLDRSD---TTESLFWIFRSKLEWDDGE 266

  Fly    74 KKKKTPSLLKASMNVFGWR-LAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAY 137
            ::..|..|:|| :.:..|| :....|:.|:..:...|. |..:...|.|.      .|:.|.|..
plant   267 RRITTFKLIKA-LFLSVWRDIVLSALLAFVYTVSCYVA-PYLMDNFVQYL------NGNRQYKNQ 323

  Fly   138 LYALGVILTSACNVLFMHPYMLGMFHIGMKA----RIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
            .|.|  :.|.....|.........|..|.||    |..:.||||.|.|.|...:....|.|:::|
plant   324 GYVL--VTTFFVAKLVECQTQRQWFFRGQKAGLGMRSVLVSMIYEKGLTLPCHSKQGHTSGEIIN 386

  Fly   199 LISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIG---ISAF-FGVAVMLLFIPLQAYLGKK 259
            |::.|..|:......|:..|:..:::.:..:::|:.:|   |:|| ..:.|||...|. |.|.:|
plant   387 LMAVDADRISAFSWFMHDPWILVLQVSLALWILYKSLGLGSIAAFPATILVMLANYPF-AKLEEK 450

  Fly   260 --TSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTL 322
              :|:::.|     |.|::..:|::..::::|:..||:.|...|..:|..|...::...|....:
plant   451 FQSSLMKSK-----DNRMKKTSEVLLNMKILKLQGWEMKFLSKILELRHIEAGWLKKFVYNSSAI 510

  Fly   323 QSFIMFVTRISVFVSLVGFVLLGKL-LTAEKAFVITAYYNILRNTMTVY-FPMGISQFAELLVSI 385
            .| :::.....:..:..|..||.|: |.:.|.....|.:.||:.  .:| .|..||...:..||:
plant   511 NS-VLWAAPSFISATAFGACLLLKIPLESGKILAALATFRILQG--PIYKLPETISMIVQTKVSL 572

  Fly   386 RRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKA 450
            .||.:|:.         .:||.:..:|:.                ||    ..:|.::.||....
plant   573 NRIASFLC---------LDDLQQDVVGRL----------------PS----GSSEMAVEISNGTF 608

  Fly   451 KWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEP 515
            .||..:...||.:::.|......||:.|.||||||||:.::|||:...||::||.|..:|.:|.|
plant   609 SWDDSSPIPTLRDMNFKVSQGMNVAICGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSP 673

  Fly   516 WLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLAR 580
            |:.:|.|.:|||||.||::..|..|::.|:|.:|.|:||:.|:|::||||.:||||||.||.:||
plant   674 WIQSGKVEENILFGKPMEREWYDRVLEACSLNKDLEILPFHDQTVIGERGINLSGGQKQRIQIAR 738

  Fly   581 AVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKIS 645
            |:|:.|||||.|||.||||.|.|.|||.:.:.|.||.:.|:.||||::||.:||:|::|..|||:
plant   739 ALYQDADIYLFDDPFSAVDAHTGSHLFKEVLLGLLRHKTVIYVTHQVEFLPEADLILVMKDGKIT 803

  Fly   646 AMGTYESMAKSGLDFAQMLTDPSKKDEGA-------------GDAPDKKSLSRQNSKLRDRHGSI 697
            ..|.|..:..||.||.:::        ||             |.|.:|.:..::|..|..:
plant   804 QAGKYHEILDSGTDFMELV--------GAHTEALATIDSCETGYASEKSTTDKENEVLHHK---- 856

  Fly   698 SSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYG------LFIVFAFFCIGAQVLAS 756
            ...|:.:::..:...:|.:| |.:|::|..:||||. |..||      :.:|...|    |:|:.
plant   857 EKQENGSDNKPSGQLVQEEE-REKGKVGFTVYKKYM-ALAYGGAVIPLILVVQVLF----QLLSI 915

  Fly   757 GGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVII------FSLV 815
            |.:.::: ||                     |.::.|.:| .:..||.|.|.|::      ..|:
plant   916 GSNYWMT-WV---------------------TPVSKDVEP-PVSGFTLILVYVLLAVASSFCILI 957

  Fly   816 RSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQI 880
            |::|......:.:|.|...|...:.||:|.||:..|.||||||.|.|....|..||.....|...
plant   958 RALLVAMTGFKMATELFTQMHLRIFRASMSFFDATPMGRILNRASTDQSVADLRLPGQFAYVAIA 1022

  Fly   881 FLAIVGIVVVLCIINVWYILATVFLVIV----FYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSAS 941
            .:.|:||:.|:..: .|.:| .||:.:|    :|  |.:|:|.:|::.||..::|||:..|.|.:
plant  1023 AINILGIIGVIVQV-AWQVL-IVFIPVVAACAWY--RQYYISAARELARLAGISRSPVVHHFSET 1083

  Fly   942 LNGLATIRAFGAQKELIAEFDNYQD------MHSSG------YYMFLATSRAFGYWLDCVCVVYI 994
            |:|:.|||:|..:.....:.....|      .||:|      :.:.|.::.||...|
plant  1084 LSGITTIRSFDQEPRFRGDIMRLSDCYSRLKFHSTGAMEWLCFRLELLSTFAFASSL-------- 1140

  Fly   995 AVITLSFFLFSPE---NGGDVGLAITQAMGMTGM---VQWGMRQSAELENTMTAVERVVEYEDL- 1052
             ||.:|    :||   |....|||||.|:.:..:   :.|.:   .:|||.|.:|||:::|.::
plant  1141 -VILVS----APEGVINPSLAGLAITYALNLNTLQATLIWTL---CDLENKMISVERMLQYTNIP 1197

  Fly  1053 -EPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGA 1116
             ||....|:   .:|.|.||..|:|...:|.::|.|.  ...||..|.....|..|.|||||||.
plant  1198 SEPPLVIET---TRPEKSWPSRGEITICNLQVRYGPH--LPMVLHGLTCTFPGGLKTGIVGRTGC 1257

  Fly  1117 GKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSD 1180
            |||:||..|||: ....|.|.||..:...:|||||||::|||||:|.:|.||:|.||||.:||:|
plant  1258 GKSTLIQTLFRIVEPAAGEIRIDGINILSIGLHDLRSRLSIIPQDPTMFEGTIRSNLDPLEEYTD 1322

  Fly  1181 AKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVD 1245
            .::||:|:..:|...|......|.|.:||.|.|:||||||||||.|.:|:.:::||:|||||::|
plant  1323 DQIWEALDNCQLGDEVRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRSKLLVLDEATASID 1387

  Fly  1246 PQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELL----------- 1299
            ..||.|||.|:|:.|.||||:|||||:.:|:|||.||::|.|...|..||..||
plant  1388 TATDNLIQETLRHHFADCTVITIAHRISSVIDSDMVLLLDQGLIKEHDSPARLLEDRSSLFSKLV 1452

  Fly  1300 ----TTSEKK 1305
                |:||.|
plant  1453 AEYTTSSESK 1462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	447/1368 (33%)
		ABC_membrane	98..367	CDD:294371	68/279 (24%)
		ABCC_MRP_domain1	443..643	CDD:213217	96/199 (48%)
		ABC_membrane	799..1027	CDD:294371	76/255 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	110/221 (50%)
ABCC6	NP_187916.3	PLN03232	67..1452	CDD:215640	447/1363 (33%)
		ABC_membrane	286..555	CDD:294371	68/286 (24%)
		ABCC_MRP_domain1	601..801	CDD:213217	96/199 (48%)
		ABC_membrane	902..1173	CDD:294371	86/314 (27%)
		ABCC_MRP_domain2	1217..1437	CDD:213211	110/221 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720