Protein Alignment Mrp5 and ABCC3

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_187915.1
• Gene: ABCC3 / 820496
• AraportID: AT3G13080
• Length: 1514
• Species: Arabidopsis thaliana
• Alignment Length: 1360
• Identity: 436/1360 - (32%)
• Similarity: 693/1360 - (50%)
• Gaps: 142/1360 - (10%)

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDH---LGSKLSAAWEKEVEKKRK 74
            |..::.|.|.|.|.:..|....|.|||||..|:   .|.|.:|.   |..|..:..|.....:|.
plant   245 PYSRAGILSLLTFSWMSPLIDIGNKKTLDLEDV---PQLHDTDSVVGLAPKFRSMLESPDGGERS 306

  Fly    75 KKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPL------FLGGLVAYYADASNQEGDNQ 133
            ...|..|:||......|.:.......||..:...|...|      :|.|...|     |.||
plant   307 GVTTFKLIKALYFTAQWEILVTAFFAFIYTVASYVGPALIDTFVQYLNGRRQY-----NHEG--- 363

  Fly   134 TKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
               |:..:..........|....:...:..:|::.|.|:.:|||.|.|.||..:....|.|:::|
plant   364 ---YVLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRTSGEIIN 425

  Fly   199 LISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVL 263
            .::.|..|:.....:|:..|:..:::|:..:::||.:|:::...:...::.:.:....|:.....
plant   426 FMTVDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPFGRMQERF 490

  Fly   264 RLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMF 328
            :.|.....|.|::..:||:..::::|:..||:.|...|..:|..|...::...| ...:.||:.:
plant   491 QEKLMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVY-NSAVISFVFW 554

  Fly   329 VTRISVFVSLVG-FVLLGKLLTAEKAFVITAYYNILRNTMTVY-FPMGISQFAELLVSIRRIQTF 391
            .....|.||..| .:|||..|.:.|.....|.:.||:.  .:| .|..||...:..||:.|:.::
plant   555 GAPTLVSVSTFGACILLGIPLESGKILSALATFRILQE--PIYNLPDTISMIVQTKVSLDRLASY 617

  Fly   392 MLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKN 456
            :.            ||.         .:|.:.:..      .:.:|:....::.|.|  .||..:
plant   618 LC------------LDN---------LQPDIVERL------PKGSSDVAVEVINSTL--SWDVSS 653

  Fly   457 TDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGT 521
            ::.||.:|:.|..|...|||.|.||||||||:.::|||:...|||:||.||.:|.:|.||:.:|.
plant   654 SNPTLKDINFKVFPGMKVAVCGTVGSGKSSLLSSLLGEVPKVSGSLKVCGTKAYVAQSPWIQSGK 718

  Fly   522 VRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKA 586
            :..|||||.||::.||..|::.|:|.:|.|:|.:.|:|::||||.:||||||.||.:|||:|:.|
plant   719 IEDNILFGKPMERERYDKVLEACSLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALYQDA 783

  Fly   587 DIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYE 651
            ||||.|||.||||.|.|.|||.:.:.|.|..:.|:.||||::||..||:|::|..|:||..|.|.
plant   784 DIYLFDDPFSAVDAHTGSHLFKEVLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYN 848

  Fly   652 SMAKSGLDFAQMLTDPSK-----KDEGAGDAPDKKSLSRQNSKLRDRHGSISSMES------AAE 705
            .:..||.||.:::....:     ....|....:|.:|.::|..::|.......:||      ..|
plant   849 DILNSGTDFMELIGAHQEALAVVDSVDANSVSEKSALGQENVIVKDAIAVDEKLESQDLKNDKLE 913

  Fly   706 SLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNG 770
            |:..:..:..:|.|.:|.:.:.:|.||. ...||..:| .|..:| |||.....|..:||:
plant   914 SVEPQRQIIQEEEREKGSVALDVYWKYI-TLAYGGALV-PFILLG-QVLFQLLQIGSNYWM---- 971

  Fly   771 EAERDTFMARLRRAFPETRINADTD-PVD------IYYFTGINVSVIIFSLVRSMLFFYLAMRSS 828
                         |: .|.::.|.. ||.      :|.......|:.|  |:|:.|......:::
plant   972 -------------AW-ATPVSEDVQAPVKLSTLMIVYVALAFGSSLCI--LLRATLLVTAGYKTA 1020

  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILP----SVMMDVMQIFLAIVGIVV 889
            |.|.:.|...:.|:.|.||::.|||||::|.|.|...||..||    ||.:.|:|    ::||:.
plant  1021 TELFHKMHHCIFRSPMSFFDSTPSGRIMSRASTDQSAVDLELPYQFGSVAITVIQ----LIGIIG 1081

  Fly   890 VLCIIN--VWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFG 952
            |:..::  |:.:...|....::|  :.:|::.:|::.||..|.::|:..|.|.:::|..|||:|
plant  1082 VMSQVSWLVFLVFIPVVAASIWY--QRYYIAAARELSRLVGVCKAPLIQHFSETISGATTIRSF- 1143

  Fly   953 AQKELIAEFDNYQDMHSSGYYMFLATSRAFGY------WLDCVCVVYIAVITLSF---FLFSPEN 1008
             .:|.....||.:  .|.||      ||...|      || |..:..::.:|..|   ||.|...
plant  1144 -SQEFRFRSDNMR--LSDGY------SRPKFYTAGAMEWL-CFRLDMLSSLTFVFSLVFLVSIPT 1198

  Fly  1009 G----GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKD 1069
            |    ...|||:|..:.:..:..|.:.....|||.:.:|||:::|..:..|.....:.| :|.:.
plant  1199 GVIDPSLAGLAVTYGLSLNTLQAWLIWTLCNLENKIISVERILQYASVPSEPPLVIESN-RPEQS 1262

  Fly  1070 WPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEG 1133
            ||..|::...||.::|.|.  ...|||.:....:|..:.|||||||:|||:||..|||: ..:.|
plant  1263 WPSRGEVEIRDLQVRYAPH--MPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAG 1325

  Fly  1134 AILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVAD 1198
            .|.||..:...:||||||.::|||||:|.:|.||||.||||.:||:|.::||:|::.:|...|..
plant  1326 EIRIDGVNILTIGLHDLRLRLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRK 1390

  Fly  1199 LPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDC 1263
            ....|.|.:||.|.|:|:||||||||.|.:|:.::|||:|||||:||..||.|||.|:|..|.||
plant  1391 KEQKLDSSVSENGDNWSMGQRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDC 1455

  Fly  1264 TVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQ---TGDSTFD 1320
            ||:|||||:.:|:|||.||::..|...|:.:|..|| ..:...|..:|.:   ...|:||
plant  1456 TVITIAHRISSVIDSDMVLLLSNGIIEEYDTPVRLL-EDKSSSFSKLVAEYTSRSSSSFD 1514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	412/1284 (32%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	431/1343 (32%)