DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC3

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1360	Identity:	436/1360 - (32%)
Similarity:	693/1360 - (50%)	Gaps:	142/1360 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDH---LGSKLSAAWEKEVEKKRK 74
            |..::.|.|.|.|.:..|....|.|||||..|:   .|.|.:|.   |..|..:..|.....:|.
plant   245 PYSRAGILSLLTFSWMSPLIDIGNKKTLDLEDV---PQLHDTDSVVGLAPKFRSMLESPDGGERS 306

  Fly    75 KKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPL------FLGGLVAYYADASNQEGDNQ 133
            ...|..|:||......|.:.......||..:...|...|      :|.|...|     |.||
plant   307 GVTTFKLIKALYFTAQWEILVTAFFAFIYTVASYVGPALIDTFVQYLNGRRQY-----NHEG--- 363

  Fly   134 TKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
               |:..:..........|....:...:..:|::.|.|:.:|||.|.|.||..:....|.|:::|
plant   364 ---YVLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRTSGEIIN 425

  Fly   199 LISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVL 263
            .::.|..|:.....:|:..|:..:::|:..:::||.:|:::...:...::.:.:....|:.....
plant   426 FMTVDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPFGRMQERF 490

  Fly   264 RLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMF 328
            :.|.....|.|::..:||:..::::|:..||:.|...|..:|..|...::...| ...:.||:.:
plant   491 QEKLMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVY-NSAVISFVFW 554

  Fly   329 VTRISVFVSLVG-FVLLGKLLTAEKAFVITAYYNILRNTMTVY-FPMGISQFAELLVSIRRIQTF 391
            .....|.||..| .:|||..|.:.|.....|.:.||:.  .:| .|..||...:..||:.|:.::
plant   555 GAPTLVSVSTFGACILLGIPLESGKILSALATFRILQE--PIYNLPDTISMIVQTKVSLDRLASY 617

  Fly   392 MLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKN 456
            :.            ||.         .:|.:.:..      .:.:|:....::.|.|  .||..:
plant   618 LC------------LDN---------LQPDIVERL------PKGSSDVAVEVINSTL--SWDVSS 653

  Fly   457 TDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGT 521
            ::.||.:|:.|..|...|||.|.||||||||:.::|||:...|||:||.||.:|.:|.||:.:|.
plant   654 SNPTLKDINFKVFPGMKVAVCGTVGSGKSSLLSSLLGEVPKVSGSLKVCGTKAYVAQSPWIQSGK 718

  Fly   522 VRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKA 586
            :..|||||.||::.||..|::.|:|.:|.|:|.:.|:|::||||.:||||||.||.:|||:|:.|
plant   719 IEDNILFGKPMERERYDKVLEACSLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALYQDA 783

  Fly   587 DIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYE 651
            ||||.|||.||||.|.|.|||.:.:.|.|..:.|:.||||::||..||:|::|..|:||..|.|.
plant   784 DIYLFDDPFSAVDAHTGSHLFKEVLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYN 848

  Fly   652 SMAKSGLDFAQMLTDPSK-----KDEGAGDAPDKKSLSRQNSKLRDRHGSISSMES------AAE 705
            .:..||.||.:::....:     ....|....:|.:|.::|..::|.......:||      ..|
plant   849 DILNSGTDFMELIGAHQEALAVVDSVDANSVSEKSALGQENVIVKDAIAVDEKLESQDLKNDKLE 913

  Fly   706 SLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNG 770
            |:..:..:..:|.|.:|.:.:.:|.||. ...||..:| .|..:| |||.....|..:||:
plant   914 SVEPQRQIIQEEEREKGSVALDVYWKYI-TLAYGGALV-PFILLG-QVLFQLLQIGSNYWM---- 971

  Fly   771 EAERDTFMARLRRAFPETRINADTD-PVD------IYYFTGINVSVIIFSLVRSMLFFYLAMRSS 828
                         |: .|.::.|.. ||.      :|.......|:.|  |:|:.|......:::
plant   972 -------------AW-ATPVSEDVQAPVKLSTLMIVYVALAFGSSLCI--LLRATLLVTAGYKTA 1020

  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILP----SVMMDVMQIFLAIVGIVV 889
            |.|.:.|...:.|:.|.||::.|||||::|.|.|...||..||    ||.:.|:|    ::||:.
plant  1021 TELFHKMHHCIFRSPMSFFDSTPSGRIMSRASTDQSAVDLELPYQFGSVAITVIQ----LIGIIG 1081

  Fly   890 VLCIIN--VWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFG 952
            |:..::  |:.:...|....::|  :.:|::.:|::.||..|.::|:..|.|.:::|..|||:|
plant  1082 VMSQVSWLVFLVFIPVVAASIWY--QRYYIAAARELSRLVGVCKAPLIQHFSETISGATTIRSF- 1143

  Fly   953 AQKELIAEFDNYQDMHSSGYYMFLATSRAFGY------WLDCVCVVYIAVITLSF---FLFSPEN 1008
             .:|.....||.:  .|.||      ||...|      || |..:..::.:|..|   ||.|...
plant  1144 -SQEFRFRSDNMR--LSDGY------SRPKFYTAGAMEWL-CFRLDMLSSLTFVFSLVFLVSIPT 1198

  Fly  1009 G----GDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKD 1069
            |    ...|||:|..:.:..:..|.:.....|||.:.:|||:::|..:..|.....:.| :|.:.
plant  1199 GVIDPSLAGLAVTYGLSLNTLQAWLIWTLCNLENKIISVERILQYASVPSEPPLVIESN-RPEQS 1262

  Fly  1070 WPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEG 1133
            ||..|::...||.::|.|.  ...|||.:....:|..:.|||||||:|||:||..|||: ..:.|
plant  1263 WPSRGEVEIRDLQVRYAPH--MPLVLRGITCTFKGGLRTGIVGRTGSGKSTLIQTLFRIVEPSAG 1325

  Fly  1134 AILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVAD 1198
            .|.||..:...:||||||.::|||||:|.:|.||||.||||.:||:|.::||:|::.:|...|..
plant  1326 EIRIDGVNILTIGLHDLRLRLSIIPQDPTMFEGTMRSNLDPLEEYTDDQIWEALDKCQLGDEVRK 1390

  Fly  1199 LPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDC 1263
            ....|.|.:||.|.|:|:||||||||.|.:|:.::|||:|||||:||..||.|||.|:|..|.||
plant  1391 KEQKLDSSVSENGDNWSMGQRQLVCLGRVLLKRSKILVLDEATASVDTATDNLIQKTLREHFSDC 1455

  Fly  1264 TVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQ---TGDSTFD 1320
            ||:|||||:.:|:|||.||::..|...|:.:|..|| ..:...|..:|.:   ...|:||
plant  1456 TVITIAHRISSVIDSDMVLLLSNGIIEEYDTPVRLL-EDKSSSFSKLVAEYTSRSSSSFD 1514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	430/1335 (32%)
		ABC_membrane	98..367	CDD:294371	61/275 (22%)
		ABCC_MRP_domain1	443..643	CDD:213217	99/199 (50%)
		ABC_membrane	799..1027	CDD:294371	70/246 (28%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	109/221 (49%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	431/1343 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720