DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC4

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_182301.1	Gene:	ABCC4 / 819392	AraportID:	AT2G47800	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1344	Identity:	447/1344 - (33%)
Similarity:	722/1344 - (53%)	Gaps:	137/1344 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPSL 81
            :::||...:.:..|...||.|..|....:.....||:::.|.....::|.|..|......:| :|
plant   255 ASVFSKTFWLWMNPLLSKGYKSPLTLEQVPTLSPEHKAERLALLFESSWPKPSENSSHPIRT-TL 318

  Fly    82 LKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILT 146
            |:..     |:......:|.|:.:|.....|:    |:..:.|.::.:..:..:.|...|.:::.
plant   319 LRCF-----WKEILFTAILAIVRLGVMYVGPV----LIQSFVDFTSGKRSSPWQGYYLVLILLVA 374

  Fly   147 SACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSV 211
            ....||..|.:......:||..|..:.:.:|:|.|:|:.:|..:..:||:||.::.|..:|...:
plant   375 KFVEVLTTHQFNFDSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQIVNYMAVDAQQLSDMM 439

  Fly   212 IHMNYLWLGPVEIGIITYLMYREIG---ISAFFGVAVMLLFIPL--QAYLGKKTSVLRLKTALRT 271
            :.::.:||.|:::.:...|:|..:|   |:|..|:..:.:||.|  |...|.:.|::.     ..
plant   440 LQLHAIWLMPLQVTVALVLLYGSLGASVITAVIGLTGVFVFILLGTQRNNGYQFSLMG-----NR 499

  Fly   272 DERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFV 336
            |.|::..||:::.::|||..|||..|:|.|...|..|...:....|   ::...|:.:....|.:
plant   500 DSRMKATNEMLNYMRVIKFQAWENHFNKRILKFRDMEFGWLSKFLY---SIAGNIIVLWSTPVLI 561

  Fly   337 SLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETK 398
            |.:.|   :.||..|.|...|..|..:.||:..:.. ||..:...::.::|:.|:.::|:.:|.
plant   562 SALTFATALALGVKLDAGTVFTTTTIFKILQEPIRT-FPQSMISLSQAMISLGRLDSYMMSKEL- 624

  Fly   399 VRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDN 463
                |||..|:.||..|..|                        :.:......||.::.:..|.:
plant   625 ----SEDAVERALGCDGNTA------------------------VEVRDGSFSWDDEDNEPALSD 661

  Fly   464 ISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILF 528
            |:.|.|..:|.|::|.||||||||:.:||||::..||.|:|.|:..|.:|..|:..|||:.||||
plant   662 INFKVKKGELTAIVGTVGSGKSSLLASVLGEMHRISGQVRVCGSTGYVAQTSWIENGTVQDNILF 726

  Fly   529 GLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDD 593
            ||||.:.:|..|:..|:||:|.:::.:.|||.:||||.:||||||.||.||||||::.|:|||||
plant   727 GLPMVREKYNKVLNVCSLEKDLQMMEFGDKTEIGERGINLSGGQKQRIQLARAVYQECDVYLLDD 791

  Fly   594 PLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGL 658
            ..||||.|.|..:|.:|:||.|:.:.|||||||:.||...|.|::|..|||...|.|:.:..|||
plant   792 VFSAVDAHTGSDIFKKCVRGALKGKTVLLVTHQVDFLHNVDCILVMRDGKIVESGKYDELVSSGL 856

  Fly   659 DFAQML--------------------TDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESA 703
            ||.:::                    |.|.........:|.....|...|.|.|.|     ::|.
plant   857 DFGELVAAHETSMELVEAGADSAAVATSPRTPTSPHASSPRTSMESPHLSDLNDEH-----IKSF 916

  Fly   704 AESLAAE--SPMQTQEGRVEGRIGMKLYKKY-FGANGYGLFIVFAFFCIGAQVLASGGDIFLSYW 765
            ..|...|  |.:..:|.|..|::.:.:||:| ..|.|:...::..||.:..|......|.:|:|.
plant   917 LGSHIVEDGSKLIKEEERETGQVSLGVYKQYCTEAYGWWGIVLVLFFSLTWQGSLMASDYWLAYE 981

  Fly   766 VN-KNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSST 829
            .: ||.                   |:.|.....:.|.....||:::.| :||....:|.::::.
plant   982 TSAKNA-------------------ISFDASVFILGYVIIALVSIVLVS-IRSYYVTHLGLKTAQ 1026

  Fly   830 TLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCII 894
            .....:...:..|.|.||:|.||||||:|.|.|...||.::|.::..|:.::..::.|.:|.|
plant  1027 IFFRQILNSILHAPMSFFDTTPSGRILSRASTDQTNVDILIPFMLGLVVSMYTTLLSIFIVTC-- 1089

  Fly   895 NVWYILATVFLVI------VFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGA 953
              .|...|.|.||      ::|  |.:||::||::.|::::|::||..|.|.|:.|:.|||:|..
plant  1090 --QYAWPTAFFVIPLGWLNIWY--RNYYLASSRELTRMDSITKAPIIHHFSESIAGVMTIRSFRK 1150

  Fly   954 QKELIAE------FDNYQ-DMHSSGYYMFLA-TSRAFGYWLDCVCVVYIAVITLSFFLFSPENGG 1010
            | ||..:      .||.: |.|::|...:|. .....|.|:.|:..:::.::..:  :..|||
plant  1151 Q-ELFRQENVKRVNDNLRMDFHNNGSNEWLGFRLELVGSWVLCISALFMVLLPSN--VIRPEN-- 1210

  Fly  1011 DVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGK 1075
             |||:::..:.:..::.:.:..|..:||.|.:|||:.::.|:..|.::|.| ...||.:||..|.
plant  1211 -VGLSLSYGLSLNSVLFFAIYMSCFVENKMVSVERIKQFTDIPSESEWERK-ETLPPSNWPFHGN 1273

  Fly  1076 IVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDR 1139
            :..:||.::|.|:  ...||:.:.:.|:|.||||:|||||:|||:||..|||| ..:.|.|:||.
plant  1274 VHLEDLKVRYRPN--TPLVLKGITLDIKGGEKVGVVGRTGSGKSTLIQVLFRLVEPSGGKIIIDG 1336

  Fly  1140 RDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQ 1204
            .|.:.||||||||:..|||||||||.||:|.|:||.::|||.::|:|||..:||.|||..|..|.
plant  1337 IDISTLGLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEQYSDEEIWKSLERCQLKDVVATKPEKLD 1401

  Fly  1205 SKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIA 1269
            |.:.:.|.|:|||||||:||.|.:|:.:|:|.:|||||:||.||||:||..||..|..||:::||
plant  1402 SLVVDNGENWSVGQRQLLCLGRVMLKRSRLLFLDEATASVDSQTDAVIQKIIREDFASCTIISIA 1466

  Fly  1270 HRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQ 1313
            ||:.||||.|:|||:|||||.||.||..||  ....:|.::|::
plant  1467 HRIPTVMDGDRVLVIDAGKAKEFDSPARLL--ERPSLFAALVQE 1508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	444/1329 (33%)
		ABC_membrane	98..367	CDD:294371	68/276 (25%)
		ABCC_MRP_domain1	443..643	CDD:213217	96/199 (48%)
		ABC_membrane	799..1027	CDD:294371	69/241 (29%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	122/221 (55%)
ABCC4	NP_182301.1	CFTR_protein	255..1502	CDD:273530	445/1336 (33%)
		ABC_membrane	331..595	CDD:294371	68/275 (25%)
		ABCC_MRP_domain1	641..841	CDD:213217	96/199 (48%)
		ABC_membrane	976..1229	CDD:294371	75/284 (26%)
		ABCC_MRP_domain2	1272..1492	CDD:213211	122/221 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720