DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and ABCC2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1440	Identity:	472/1440 - (32%)
Similarity:	750/1440 - (52%)	Gaps:	146/1440 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKKK 77
            |.:.:|||..:.|.:..|....|.|:.|.|.|::......:::.|.:....:|:||::|.:
plant   227 PEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSFQHSWDKELQKPQ---- 287

  Fly    78 TPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALG 142
             |.||:|..|..|.|....|    ..:||...:|  |:|.|:......|.||.......|:||..
plant   288 -PWLLRALNNSLGGRFWWGG----FWKIGNDCSQ--FVGPLLLNQLLKSMQEDAPAWMGYIYAFS 345

  Fly   143 VILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRL 207
            :.:.....||....|...:..:|.:.|.|:.:.::||:|||:.........|::.||::.|...|
plant   346 IFVGVVFGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKITNLMTTDAESL 410

  Fly   208 DVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTD 272
            ......::.:|..|..|.|...|:|:::|:::..|..:::|..|||..:..|...|..:...|||
plant   411 QQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKLTKEGLQRTD 475

  Fly   273 ERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS 337
            :|:.:|||:::.:..:|.||||..|...:..||..|::..|. :.:.|.|..||:  ..|.|.|:
plant   476 KRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRK-SQLLGALNMFIL--NSIPVLVT 537

  Fly   338 LVG---FVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKV 399
            :|.   |.|||..||..:||...:.:.:||..:.: .|..|:|.....||::|::..:..||..
plant   538 IVSFGVFTLLGGDLTPARAFTSLSLFAVLRFPLFM-LPNIITQVVNANVSLKRLEEVLATEERI- 600

  Fly   400 RDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNI 464
                            |:..|.:              ...|.:|.|......||.|....||.||
plant   601 ----------------LLPNPPI--------------EPGEPAISIRNGYFSWDSKGDRPTLSNI 635

  Fly   465 SLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGS-VKVNGTLSYASQEPWLFTGTVRQNILF 528
            :|......||||:|..|.||:|||.|:||||...|.: |.:.|:::|..|..|:|..|||.||||
plant   636 NLDVPLGSLVAVVGSTGEGKTSLISAILGELPATSDAIVTLRGSVAYVPQVSWIFNATVRDNILF 700

  Fly   529 GLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDD 593
            |.|.|:.:|...:...:|:.|.||||..|.|.:||||.::|||||.|:|:|||||..:|:|:.||
plant   701 GSPFDREKYERAIDVTSLKHDLELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDD 765

  Fly   594 PLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGL 658
            ||||:|.|||:.:|::|::..|.::..:|||:||.||.|.|.||::.:|.:...||||.::.:|.
plant   766 PLSALDAHVGQQVFEKCIKRELGQKTRVLVTNQLHFLSQVDRIVLVHEGTVKEEGTYEELSSNGP 830

  Fly   659 DFAQMLTDPSKKD-------EGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQ 716
            .|.:::.:..|.:       |...|...::.::..|:......||.............:|.:..|
plant   831 LFQRLMENAGKVEEYSEENGEAEADQTAEQPVANGNTNGLQMDGSDDKKSKEGNKKGGKSVLIKQ 895

  Fly   717 EGRVEGRIGMKLYKKYFGANGYGLFIVFAFFC-IGAQVLASGGDIFLSYWVNKNGEAERDTFMAR 780
            |.|..|.:..::.|:|..|.|....::....| :..:|.......:||.|.:.............
plant   896 EERETGVVSWRVLKRYQDALGGAWVVMMLLLCYVLTEVFRVTSSTWLSEWTDAGTPKSHGPLFYN 960

  Fly   781 LRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMH 845
            |                 ||..  ::...::.:|..|......::.::..||:.|...:.||.|.
plant   961 L-----------------IYAL--LSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHSILRAPMS 1006

  Fly   846 FFNTNPSGRILNRFSKDLGQVDE---ILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVI 907
            ||:|||.|||:|||:||||.:|.   :..::.|..:...|:.|.::.::..:::|.|:.   |::
plant  1007 FFHTNPLGRIINRFAKDLGDIDRTVAVFVNMFMGQVSQLLSTVVLIGIVSTLSLWAIMP---LLV 1068

  Fly   908 VFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGY 972
            :||...::|.:|:|:|||:::::|||:|:....:||||:||||:.|       :|...|::....
plant  1069 LFYGAYLYYQNTAREVKRMDSISRSPVYAQFGEALNGLSTIRAYKA-------YDRMADINGRSM 1126

  Fly   973 -------YMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPENG---------GDVGLAITQAMG 1021
                   .:.:..:|..|..|:.:..:.| .:|.||.:.  :||         ..:||.::.|:.
plant  1127 DNNIRFTLVNMGANRWLGIRLETLGGLMI-WLTASFAVM--QNGRAENQQAFASTMGLLLSYALN 1188

  Fly  1022 MTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKP---NKKPPKDWPEDGKIVFDDLSL 1083
            :|.::...:|.::..||::.|||||..|.::.|    |:.|   |.:||..||..|.|.|:|:.|
plant  1189 ITSLLTGVLRLASLAENSLNAVERVGNYIEIPP----EAPPVIENNRPPPGWPSSGSIKFEDVVL 1249

  Fly  1084 KYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGL 1147
            :|.|....  ||..::..|...:|||||||||||||||:|||||: ...:|.||||..|....||
plant  1250 RYRPQLPP--VLHGVSFFIHPTDKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDCDVGKFGL 1312

  Fly  1148 HDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGT 1212
            .|||..:.||||.|||||||:|:|||||.|::||.||||||...||..:...|.||.:::||.|.
plant  1313 MDLRKVLGIIPQSPVLFSGTVRFNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDAEVSEAGE 1377

  Fly  1213 NFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMD 1277
            |||||||||:.|:||:||.::|||:|||||.||.:||||||.|||.:||.||:|.|||||:|::|
plant  1378 NFSVGQRQLLSLSRALLRRSKILVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAHRLNTIID 1442

  Fly  1278 SDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDAL----------------LKVA 1326
            .||:||:|:|:..||.|| |.|.::|...|..||:.||.:..:.|                |:..
plant  1443 CDKILVLDSGRVQEFSSP-ENLLSNEGSSFSKMVQSTGAANAEYLRSLVLDNKRAKDDSHHLQGQ 1506

  Fly  1327 QK--------VGLRFKIQCNLSTCLSSLSSFQAHDDNLRLKKDSXHFAVPKAFKD--YILKILEP 1381
            :|        ...:|.:..:|::..:.|.|.:..||:..||:.:......::..:  :..:|.|.
plant  1507 RKWLASSRWAAAAQFALAASLTSSHNDLQSLEIEDDSSILKRTNDAVVTLRSVLEGKHDKEIAES 1571

  Fly  1382 ITNHPAANAG 1391
            :..|..:..|
plant  1572 LEEHNISREG 1581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	450/1321 (34%)
		ABC_membrane	98..367	CDD:294371	77/271 (28%)
		ABCC_MRP_domain1	443..643	CDD:213217	94/200 (47%)
		ABC_membrane	799..1027	CDD:294371	68/246 (28%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	128/221 (58%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	472/1440 (33%)
		ABC_membrane	309..570	CDD:279056	77/265 (29%)
		ABCC_MRP_domain1	614..815	CDD:213217	94/200 (47%)
		ABC_membrane	925..1179	CDD:294371	70/285 (25%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	128/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720