DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and TAP2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_000535.3	Gene:	TAP2 / 6891	HGNCID:	44	Length:	703	Species:	Homo sapiens

Alignment Length:	650	Identity:	151/650 - (23%)
Similarity:	278/650 - (42%)	Gaps:	89/650 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 GAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGM----KLYKKYF 733
            ||..||..:..|...|.|...:|:.....|....|:.....:.::.:|..::.|    ||.:...
Human    85 GASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDL 149

  Fly   734 GANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVD 798
            .      .:|.|||.:   |||..|:..:.::..:..:.                 :..|.||
Human   150 P------LLVAAFFFL---VLAVLGETLIPHYSGRVIDI-----------------LGGDFDP-- 186

  Fly   799 IYYFTGINVSVIIFSLVRSM-------LFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRIL 856
             :.|......:.:||...|:       .|.|...|.:..:...:|..:.|..:.||....:|.:.
Human   187 -HAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELN 250

  Fly   857 NRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSR 921
            :|.|.|...:...||.....:::..:.:||:...:..|:....|.::..:.........|.:..:
Human   251 SRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQ 315

  Fly   922 DVKR--LEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYY-------MFLA 977
            :|.|  .:||.|:.  ..:..::.||.|:|:|||::..:..:....:.....|:       ::|.
Human   316 EVLREIQDAVARAG--QVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLL 378

  Fly   978 TSRAFGYWLDCVCVVYIAV--ITLSFFLFSPENGGDVGLAITQAMGMTGM---------VQWGMR 1031
            ..|          |:::.|  :.||..|...::|     .:||...::.|         ||..:.
Human   379 VRR----------VLHLGVQMLMLSCGLQQMQDG-----ELTQGSLLSFMIYQESVGSYVQTLVY 428

  Fly  1032 QSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLR 1096
            ...::.:.:.|.|:|..|.|.:|.   ...|....|...  .|.:.|.|:|..| |::....||:
Human   429 IYGDMLSNVGAAEKVFSYMDRQPN---LPSPGTLAPTTL--QGVVKFQDVSFAY-PNRPDRPVLK 487

  Fly  1097 SLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNE--GAILIDRRDTNDLGLHDLRSKISIIPQ 1159
            .|...:...|...:||..|:|||: :.||.:..|..  |.:|:|.:..:......|.|::..:.|
Human   488 GLTFTLRPGEVTALVGPNGSGKST-VAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQ 551

  Fly  1160 EPVLFSGTMRYNLD-PFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVC 1223
            |||||||::|.|:. ......|.|:..:.:.......:.::..|:.:.:.|.|:..:.||:|.:.
Human   552 EPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLA 616

  Fly  1224 LARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGK 1288
            :|||::|:.|:|::||||:.:|.|.:..:|..  |...|.|||.|||||..|..:.::||:..||
Human   617 IARALVRDPRVLILDEATSALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGK 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	150/649 (23%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	46/254 (18%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	69/217 (32%)
TAP2	NP_000535.3	3a01208	1..697	CDD:273363	150/649 (23%)
		Part of the peptide-binding site. /evidence=ECO:0000269\|PubMed:8955196	301..389		18/99 (18%)
		Part of the peptide-binding site. /evidence=ECO:0000269\|PubMed:8955196	414..433		2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910