DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and TAP1

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_000584.3	Gene:	TAP1 / 6890	HGNCID:	43	Length:	748	Species:	Homo sapiens

Alignment Length:	633	Identity:	145/633 - (22%)
Similarity:	269/633 - (42%)	Gaps:	100/633 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   734 GANGYGLFIVFAFFCIGAQ-----------VLASGGDIFLSY-------WVNKNGEAERDTFMAR 780
            |..|.|..:.....|:|::           ||:|.|::.:.:       |:.::|.|  |||...
Human   165 GQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSA--DTFTRN 227

  Fly   781 LRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMH 845
            |      |.::..|....:..|.|..:.......|.|            .|...:|..|.|....
Human   228 L------TLMSILTIASAVLEFVGDGIYNNTMGHVHS------------HLQGEVFGAVLRQETE 274

  Fly   846 FFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINV--W-YILATVFLVI 907
            ||..|.:|.|::|.::|...:.:.|    .:.:.:||..  :|..||::.:  | .:..|:..:|
Human   275 FFQQNQTGNIMSRVTEDTSTLSDSL----SENLSLFLWY--LVRGLCLLGIMLWGSVSLTMVTLI 333

  Fly   908 VFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLA---TIRAFG-----AQK--ELIAEFD 962
            ...||.:......:..:.||...|..:......::..|:   |:|:|.     |||  |.:.|..
Human   334 TLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIK 398

  Fly   963 NYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIA--VITLSFFLFSPENGGDVGLAITQAMGMTGM 1025
            ......:..|.:...|:...|..|. |.::||.  ::|     ....:.|::...:...|..|..
Human   399 TLNQKEAVAYAVNSWTTSISGMLLK-VGILYIGGQLVT-----SGAVSSGNLVTFVLYQMQFTQA 457

  Fly  1026 VQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPE----DGKIVFDDLSLKYF 1086
            |:..:.....::..:.:.|::.||.|..|         :.||.....    :|.:.|.|:|..|
Human   458 VEVLLSIYPRVQKAVGSSEKIFEYLDRTP---------RCPPSGLLTPLHLEGLVQFQDVSFAY- 512

  Fly  1087 PDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNE--GAILIDRRDTNDLGLHD 1149
            |::....||:.|...:...|...:||..|:|||: :.||.:..|..  |.:|:|.:.........
Human   513 PNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKST-VAALLQNLYQPTGGQLLLDGKPLPQYEHRY 576

  Fly  1150 LRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQV-------VADLPSGLQSKI 1207
            |..:::.:.|||.:|..:::.|:    .|...:. .::||:....|       ::.||.|..:::
Human   577 LHRQVAAVGQEPQVFGRSLQENI----AYGLTQK-PTMEEITAAAVKSGAHSFISGLPQGYDTEV 636

  Fly  1208 SEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFK--DCTVLTIAH 1270
            .|.|:..|.||||.|.||||::|:..:|::|:||:.:|..:...::..:....:  ..:||.|..
Human   637 DEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQ 701

  Fly  1271 RLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKK-VFHSMVKQTGDS 1317
            .|..|..:|.:|.::.|...|.|:..:|:   ||| .:.:||:...|:
Human   702 HLSLVEQADHILFLEGGAIREGGTHQQLM---EKKGCYWAMVQAPADA 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	139/613 (23%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	49/242 (20%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	63/231 (27%)
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	142/625 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910