DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and abcc12

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:XP_009301629.1 Gene:abcc12 / 568482 ZFINID:ZDB-GENE-050517-25 Length:1368 Species:Danio rerio


Alignment Length:1365 Identity:475/1365 - (34%)
Similarity:764/1365 - (55%) Gaps:112/1365 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 NPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHL-GSKLSAAWEKEVEKKRKK 75
            :|.:.:..||...|.:..|..::..:..|||:.|:  |..|...|: |.:....|::||.:    
Zfish    67 HPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF--LSPHDGAHINGERFQRLWDEEVAR---- 125

  Fly    76 KKTPSLLKASMNVFGWRLAGLG-LVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLY 139
               ..|.|||::....|..... :|.|:..:.|...  :|:|..:..| :..|....::....::
Zfish   126 ---VGLEKASLSAVIMRFQKTRFIVSFLASVMFAFA--VFVGPSILVY-EILNYVEQSEPSTVVH 184

  Fly   140 ALGVILTSACNVLFMHPYMLGMF---------HIGMKARIAMTSMIYRKALRLSRTALGDTTIGQ 195
            .:||     |..||:..:....|         ...::.:.|.:.:.::|.:.|  .:|...|:|:
Zfish   185 GVGV-----CVALFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISL--RSLTTITVGE 242

  Fly   196 VVNLISNDVGRLDVSVIHMNYLWLGPVEIGI-ITYLMYREIGISAFFGVAVMLLFIPLQAYLGKK 259
            .:|::::|..||..:||...:|...||.:.| |.|..: .:|.:|..|:.|.|:|:|:|..:.:.
Zfish   243 TINVLTSDGYRLFDAVIFGTFLLCVPVLLIICIIYACF-ILGYTALIGILVYLIFLPIQFSIARL 306

  Fly   260 TSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQS 324
            ..|.|.:....||:|||.|||:::.|::|||||||..|.|.|..:|..|...::...|::....|
Zfish   307 IGVFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSLNSS 371

  Fly   325 FIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQ 389
            ....|..::..|:.:....|...|....|:.|.|.:|.:|.:|.: .|..:...||..|::.|::
Zfish   372 LTTIVPTLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSMGL-LPFSVKAVAEAKVALTRLK 435

  Fly   390 TFMLHEETK---VRDKSEDLDEQKLGKAGLIAEPTVAQTTGVL--KPSSRRTSEAEHSIVISKLK 449
            ..||.:..|   .:||:.|| ...:.||.....||..:.|..:  .||.....:||         
Zfish   436 RIMLVQNPKGYLTQDKNMDL-ALVMEKATFSWSPTDDKNTSQMPENPSQNGKHKAE--------- 490

  Fly   450 AKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQE 514
                   :..:|.||||......|:.|.|.|||||:|||.::|.:::..||||..||||:|.||:
Zfish   491 -------SQPSLRNISLTLSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGTLAYVSQQ 548

  Fly   515 PWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLA 579
            .|:|.||||.|||.|.|.|:.||.:|:..|.|:.|..:|||.|:|.:||||.:||||||.|:|||
Zfish   549 AWIFHGTVRDNILMGEPFDEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVSLA 613

  Fly   580 RAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKI 644
            ||||...||:||||||||||.|||:|:|::|::..|:.:.|:|||||||:||..|.::::|.|:|
Zfish   614 RAVYSNRDIFLLDDPLSAVDAHVGKHIFEECIKKELKGKSVILVTHQLQYLEFCDEVMLLDNGEI 678

  Fly   645 SAMGTYESMAKSGLDFAQMLTDP--SKKDEGAGDAP-----DKKSLSRQNSKLR----------- 691
            ...||:..:.|:...::|::|:.  .:.:|.|...|     |.:..:....|..           
Zfish   679 KEAGTHSDLMKTKGRYSQLITNVHLEQNNERADSKPQTEHNDSEQTNPDEPKANGIENPAFDMSD 743

  Fly   692 DRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYF-GANGY-GLFIVFAFF--CIGAQ 752
            ::..:..:.:.::|:...:..:.|:|...||.:..:.|.:|. .|.|| .||:|...|  .:|:.
Zfish   744 EKPATNETPKDSSETKGKKDQLVTREVAQEGSVTWRTYHQYCQAAGGYILLFLVVLLFTLLVGST 808

  Fly   753 VLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTDPVDIYY---FTGINVSVIIFSL 814
            ..::.   :||||::: |.....:..|.....      |...:|...:|   :..|.:::|:.|:
Zfish   809 AFSNW---WLSYWLDQ-GSGNNSSSNATSNSG------NISENPDLSFYQMVYGVIIIAMIVLSI 863

  Fly   815 VRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQ 879
            ::...|..:.:|||:.||:|||:.:..:.|.||:|.|:||::||||||..:||.:||..|.:.:|
Zfish   864 LKGYTFTKVTLRSSSKLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQ 928

  Fly   880 IFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNG 944
            ..|.:...::.:||:..:.::|.|.|.::|..:...:..:.|.:||:|.|:|||..|..::::.|
Zfish   929 FCLIVTFTLLTICIVFPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQG 993

  Fly   945 LATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPE-- 1007
            |:||.|:..:::.|..|....|.:|:.:.:|.|.:|...:|||.:......:::| |.:.||.  
Zfish   994 LSTIHAYDKRQQYIERFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSL-FVVLSPNET 1057

  Fly  1008 -NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY-EDLEPEGDFESKPNKKPPKDW 1070
             |....|||::..:.:||::|:.:|.|.|:|...|:|||::|| .....||....| :...|..|
Zfish  1058 INPSLKGLALSYTIQLTGILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGPRRVK-DANIPAGW 1121

  Fly  1071 PEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSY-NEGA 1134
            |::|.|.|.:.|::|..:  ...||.:|||.|...||:|||||||:|||||..|||||:. .||.
Zfish  1122 PQEGTITFKNYSMRYRDN--TPIVLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGT 1184

  Fly  1135 ILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADL 1199
            ||||..|...|||.||||::|:|||:||||.||:|||||||:.|.|.:||.:||:..:|..::.|
Zfish  1185 ILIDDMDICKLGLKDLRSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKL 1249

  Fly  1200 PSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCT 1264
            |..|||.:.|.|.|||||:|||:|:|||:||.::|:::|||||::|.:||:|||.|||:.|:.||
Zfish  1250 PEKLQSPVVENGENFSVGERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCT 1314

  Fly  1265 VLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQKV 1329
            :||||||::||::||::||||.||.:||..|.:|:             |..:|.|.:||..|.:|
Zfish  1315 MLTIAHRINTVLESDRILVMDQGKVIEFDPPQDLI-------------QRPNSLFASLLAAANQV 1366

  Fly  1330  1329
            Zfish  1367  1366

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 468/1334 (35%)
ABC_membrane 98..367 CDD:294371 73/278 (26%)
ABCC_MRP_domain1 443..643 CDD:213217 100/199 (50%)
ABC_membrane 799..1027 CDD:294371 73/233 (31%)
ABCC_MRP_domain2 1074..1295 CDD:213211 125/221 (57%)
abcc12XP_009301629.1 CFTR_protein 68..1366 CDD:273530 474/1362 (35%)
ABC_membrane 149..414 CDD:294371 72/275 (26%)
ABCC_MRP_domain1 457..677 CDD:213217 109/235 (46%)
ABC_membrane 809..1077 CDD:294371 81/278 (29%)
ABCC_MRP_domain2 1125..1345 CDD:213211 125/221 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170586093
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.660

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