DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc6a

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_009300481.1	Gene:	abcc6a / 566555	ZFINID:	ZDB-GENE-050517-18	Length:	1507	Species:	Danio rerio

Alignment Length:	1401	Identity:	477/1401 - (34%)
Similarity:	756/1401 - (53%)	Gaps:	176/1401 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ADELP------EN--PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLS 62
            ||:.|      :|  |.:.::..|.::|.:.....|||.:..|...||:...:|..|:.:.|.|.
Zfish   190 ADQAPLGKAVHKNACPVQDASFLSKILFWWFSGLIFKGYRSPLQAEDLWSLREEDTSERIISDLE 254

  Fly    63 AAW--------------------------EKEVEKKRKKKKTPS--LLKASMNVFG-WRLAGLGL 98
            ..|                          :.::.:|.:|:::..  ||:.....|| :.|.|. |
Zfish   255 EEWTAKRTKLQQQENHMSTSAALGSRLPDQAQLLRKIQKEQSSGFCLLRTLARSFGPYFLTGT-L 318

  Fly    99 VLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFH 163
            .|.:.:: |..:.|..|..|:.:..|    |.....|.|.||..:.|.|....:|.|.|....|.
Zfish   319 CLIVHDV-FMFSVPQVLSLLLGFMKD----EDTPLWKGYFYATLMFLLSCLQSVFNHQYTYTCFT 378

  Fly   164 IGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIIT 228
            :||:.:.|:..::|||:|.::.:|....|:|::|||:|.|..:|...|::.|.:||.|:|:.:..
Zfish   379 VGMRVKTAVMGLVYRKSLVMNSSARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEVTLCL 443

  Fly   229 YLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAW 293
            :.:::.:|.||..|:|.::...||..::.:|.|.|:.......|.||::||||::||:::|.|||
Zfish   444 FFLWQHLGPSALAGIATVIFIFPLNGFIARKRSKLQEIQMKYMDGRVKLMNEILNGIKILKFYAW 508

  Fly   294 EIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS---LVGFVLLG--------KL 347
            |..|.:.:...|.||:..::         :|.|::...::.|.|   |:.|.:.|        .:
Zfish   509 EKAFLEQVLGYREKELKTLK---------KSQILYSVSLASFNSSSFLIAFAMFGVYVLIDDKNV 564

  Fly   348 LTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLG 412
            |.|:|.||..|..|||:..:: ..|..:|...:.|||::|:..|:..:|
Zfish   565 LDAQKIFVSMALINILKTPLS-QLPFAMSTTMQALVSLKRLGKFLCQDE---------------- 612

  Fly   413 KAGLIAEPTVAQTTGVLKPS--SRRTSEAE-HSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLV 474
                            |||.  :|.:.::: ..:|.......| .|:....|..||:|.....||
Zfish   613 ----------------LKPDNVARESFKSDVDGVVFDNGTFSW-SKDGPPCLKRISVKVPCGSLV 660

  Fly   475 AVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRT 539
            ||:|.||||||||:.|:|||....||:|.|.|:::|..|:.|:...:::.|||||....:..|:.
Zfish   661 AVVGHVGSGKSSLLSAMLGETEKRSGTVSVKGSIAYVPQQAWIQNASLQDNILFGREKKESWYQR 725

  Fly   540 VVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGR 604
            |::.|||..|.:.||..|.|.:||:|.:||||||.|:|||||||||.|:|||||||||||.|||:
Zfish   726 VLEACALLPDLDNLPAGDATEIGEKGLNLSGGQKQRVSLARAVYRKGDVYLLDDPLSAVDAHVGQ 790

  Fly   605 HLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY-ESMAKSG--LDFAQML 664
            |:|::.:  :|.||::..:||||.:.||.|||:|:::..|:||..|:| |.:.::|  .||....
Zfish   791 HIFNKVIGPKGILRDKTRVLVTHGMSFLPQADLILVLVDGEISERGSYQELLNRNGAFADFIHTF 855

  Fly   665 TDPSKKD--EGAGDAPDKKSL----------SRQNSKLRDRHGSISSMESAAESL--AAESPMQT 715
            .:..:|:  ..|.....:||:          ||..|:.:...|..:|:  |.|.|  :.|..:..
Zfish   856 ANSERKECFSEALQRGSRKSVRLSVTDYMPFSRDLSQEQLIGGDTNSI--AIEPLPDSDEDHIPE 918

  Fly   716 QEGRVE-------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNK---NG 770
            ..|::.       ||:.:::|.:||...|..|.|...|.....|..:...:.:||.|.::   ||
Zfish   919 DLGKLTKVDKARIGRVKLEMYIEYFRTIGLPLIISIVFLYAFQQAASLSNNYWLSLWADQPVING 983

  Fly   771 EAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIF-SLVRSMLFFYLAMRSSTTLHNT 834
                             |::|.|. .:.:|...|....:.|| :.|...|...:|.|.   ||..
Zfish   984 -----------------TQLNTDL-KLGVYGALGFAQGISIFGTTVAISLGCIIASRH---LHLD 1027

  Fly   835 MFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYI 899
            :...|..:.|.||.:.|||.:||||:|::..:|.::|..:..::..|..:..:    |||   .:
Zfish  1028 LLNNVLHSPMSFFESTPSGNLLNRFAKEIDAIDNMIPDGLKMMLSYFFKLTEV----CII---VL 1085

  Fly   900 LATVF-------LVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKEL 957
            :||.|       :|.::..::.||::||..::|||:|:|||||:||:.::.|.:.||||..|...
Zfish  1086 MATPFAAVIILPMVFLYGFIQSFYVATSCQLRRLESVSRSPIYTHLNETVQGASVIRAFNEQSRF 1150

  Fly   958 IAEFDNYQDMHSSGYY-MFLATSRAFGYWLDCV-CVVYIAVITLSFFLFSPENGGDVGLAITQAM 1020
            |...::..|.:.:.|: .|:|| |..|..|:.: ..:.:|...||.......:.|.||||::.::
Zfish  1151 IMGANHKVDHNQTAYFPRFIAT-RWLGVNLEFLGNGIVLAASILSVMAKGTLSPGMVGLAVSHSL 1214

  Fly  1021 GMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKY 1085
            .:||.:.|.:|...::||.:.:||||.||.|...|..:..:.:..|| .||:.|.|.|.|..|:|
Zfish  1215 QVTGFLSWIVRSWTDVENNIVSVERVKEYADTPKEAAWSIEGSSLPP-SWPQTGTIEFQDYGLQY 1278

  Fly  1086 FPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHD 1149
              .|..:..|:.:::.|...||:|||||||||||||...:|| |...:|.|.||..:..::||||
Zfish  1279 --RKGLELALKGISVHIHEREKIGIVGRTGAGKSSLALGIFRILEAAKGEIYIDGINIAEIGLHD 1341

  Fly  1150 LRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNF 1214
            |||:|:||||:||||||::|.|||||:.|||.::|.:||...||..|::||..|..:.||||.|.
Zfish  1342 LRSRITIIPQDPVLFSGSLRMNLDPFNAYSDEEVWNALELAHLKNFVSELPDKLNHECSEGGENL 1406

  Fly  1215 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSD 1279
            |:|||||||||||:||:.::||:|||||.:|.:||.|||:|||::|:||.||||||||:|:||..
Zfish  1407 SLGQRQLVCLARALLRKTKVLVLDEATAALDLETDTLIQSTIRSQFEDCAVLTIAHRLNTIMDYT 1471

  Fly  1280 KVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||:|||.|..||..||..|:  :::..|:.|.::.|
Zfish  1472 KVIVMDKGHVVEMDSPSNLI--AKRGQFYYMCREAG 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	471/1372 (34%)
		ABC_membrane	98..367	CDD:294371	84/279 (30%)
		ABCC_MRP_domain1	443..643	CDD:213217	96/201 (48%)
		ABC_membrane	799..1027	CDD:294371	72/237 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	124/221 (56%)
abcc6a	XP_009300481.1	MRP_assoc_pro	5..1506	CDD:188098	477/1401 (34%)
		ABC_membrane	317..584	CDD:279056	84/281 (30%)
		ABCC_MRP_domain1	630..831	CDD:213217	96/201 (48%)
		ABC_membrane	955..1218	CDD:279056	80/291 (27%)
		ABCC_MRP_domain2	1267..1487	CDD:213211	124/221 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660