DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and Abcb9

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	701	Identity:	159/701 - (22%)
Similarity:	294/701 - (41%)	Gaps:	149/701 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   649 TYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPM 713
            ||.|:|.|.|.:..:.|          ..||.::|...|.......|:.:...|
Mouse   123 TYISLAASFLLWGLLAT----------VRPDAEALEPGNEGFHGEGGAPAEQAS----------- 166

  Fly   714 QTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFM 778
                       |..|.|..........|:|.|.|.:   ::|:.|:.||.|:..
Mouse   167 -----------GATLQKLLSYTKPDVAFLVAASFFL---IVAALGETFLPYYTG----------- 206

  Fly   779 ARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSL-------VRSMLFFYLAMRSSTTLHNTMF 836
                ||.....|....|     .||...|.|.:.::       :|..:|..:..|.:..|.|.:|
Mouse   207 ----RAIDSIVIQKSMD-----QFTTAVVVVCLLAIGSSLAAGIRGGIFTLVFARLNIRLRNCLF 262

  Fly   837 QGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILA 901
            :.:......||:.|.:|.:::|.:.|...|.:::...:...::..:.:.|:||.:..:: |.:..
Mouse   263 RSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINIFLRNTVKVTGVVVFMFSLS-WQLSL 326

  Fly   902 TVF-----LVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEF 961
            ..|     :::|..:...:|...|::|:  .|:.|:.  :....:::.:.|:|:|..::|....|
Mouse   327 VTFMGFPIIMMVSNIYGKYYKRLSKEVQ--SALARAS--TTAEETISAMKTVRSFANEEEEAEVF 387

  Fly   962 -DNYQDMH-----SSGYYMFLATSRAFGYWLDCVCVVY----------------IAVITLSFFLF 1004
             ...|.::     .:..||...........:..|.::|                ||.|...|.|
Mouse   388 LRKLQQVYKLNRKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAFIIYEFVL- 451

  Fly  1005 SPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEP----EGDFESKPNKK 1065
                 ||       .|...|.|..|:.|.      :.|.|:|.|:.|.:|    :|...
Mouse   452 -----GD-------CMESVGSVYSGLMQG------VGAAEKVFEFIDRQPTMVHDGSLA------ 492

  Fly  1066 PPKDWPE--DGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL 1128
                 |:  :|::.|::::..| ..:....||::::.::...:...:||.:|:||||.:|.|...
Mouse   493 -----PDHLEGRVDFENVTFTY-RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 551

  Fly  1129 -SYNEGAILIDRRDTNDLGLHD---LRSKISIIPQEPVLFSGTMRYNLD------PFDEYSDAKL 1183
             ....|.:|:|.:   .:|.:|   |...||::.||||||:.::..|:.      ||:     .:
Mouse   552 YPLQGGRVLLDGK---PIGAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFE-----MV 608

  Fly  1184 WESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQT 1248
            .|:.::......:.:|..|..::..|.|...|.||:|.|.:|||::|...:|::||||:.:|.::
Mouse   609 VEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAES 673

  Fly  1249 DALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELL 1299
            :.|||..|....:..|||.|||||.||..:..::|:|.|:.|:.|:..:||
Mouse   674 EYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	159/701 (23%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371	47/261 (18%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	70/230 (30%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	159/701 (23%)
		ABC_membrane	189..451	CDD:279056	52/289 (18%)
		ABCC_TAP	489..714	CDD:213215	70/244 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000