DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc9

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_005164758.1	Gene:	abcc9 / 561160	ZFINID:	ZDB-GENE-050517-23	Length:	1583	Species:	Danio rerio

Alignment Length:	1410	Identity:	418/1410 - (29%)
Similarity:	710/1410 - (50%)	Gaps:	167/1410 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NIFSSLMFCFAMPTFFKGRKKTLDENDL------YRALQEHRSDHLGSKLSAAWEKEVEKKRKKK 76
            |:.|...:.:..|......|:.::...:      .|||..:      .:|..::|::.:.....:
Zfish   223 NLLSKATYWWMNPLIIGAHKRPIELKKIGKLPIAMRALTNY------LRLKDSYEEQRQNTEDPE 281

  Fly    77 KTPSLLKASMNVFGWRLAGLGLVLFILE-IGFRVTQPLFLGGLVAYY-----ADASNQEGDNQTK 135
            |:||:.|:....||..:.......::.: :||  ..||.:.|:|.:.     .|.:|:.|:....
Zfish   282 KSPSIWKSMYRAFGGSILLSSTFRYMADLLGF--AGPLCISGIVEHLHNSTEIDRTNKTGNMTFG 344

  Fly   136 AYLYA----------LGVILTSACNVLFMHPYMLGMFHI----GMKARIAMTSMIYRKALRLSRT 186
            .|..:          |.|:|..|  ::....::...:::    |:..|.|:.:|||.|.||||.:
Zfish   345 VYFMSSTELLQNTSVLAVLLFLA--LVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTS 407

  Fly   187 --ALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLF 249
              ::|:.|:||:.||::.:..:|...:.....||..||:|.:...|:|..:|.||..|..|:||.
Zfish   408 NMSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLL 472

  Fly   250 IPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRN 314
            .|:|..:..|.:.::..|...:.:|::...||:.||:::|:||||..|...:...|.||:.
Zfish   473 APVQYLIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELT---- 533

  Fly   315 VNYIRGTLQSFIMFVTRISVFVS--------LVGFVLLGKL----LTAEKAFVITAYYNILRNTM 367
                  :|::|.:. |.:|:|::        |..||....:    |:..|||...|.::||   :
Zfish   534 ------SLKTFALH-TSMSIFMNAAIPIAAVLATFVTHAYIEEDRLSPAKAFASLALFHIL---V 588

  Fly   368 TVYFPMG-ISQFA-ELLVSIRRIQTFMLHEETKVRD---KSEDL--------------DEQKLGK 413
            |..|.:. :.:|| :.|||::::..|:..:|  :.|   ::.|:              |.:.:.:
Zfish   589 TPLFLLSTVVRFAVKALVSVQKLSEFLQSDE--IGDDSWRNGDMCMSLEVGKKYKYQGDTKAINR 651

  Fly   414 AGLIAEPTVAQTTGVLKPSSR--RTSEAEH-SIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVA 475
            .|........|      |..|  |.||.|. ::.::.....|.  :..:||.:|:::....||..
Zfish   652 KGRYRMDNYEQ------PVRRQLRPSETEDVAVQVNDGFFTWG--SNLSTLSDINIRIPTGQLTM 708

  Fly   476 VIGPVGSGKSSLIQAVLGELNPDSGSV--------------KVNG---------------TLSYA 511
            ::|.||.|||||:.|:|||:...||.|              .::|               :::||
Zfish   709 IVGQVGCGKSSLLLAMLGEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYA 773

  Fly   512 SQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARI 576
            :|:.||...||.:||.||.|.:|.||:.|:..|:|:.|.:|||:.|:|.:||||.:|||||:.||
Zfish   774 TQKSWLLNATVEENITFGSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRI 838

  Fly   577 SLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREE--IVLLVTHQLQFLEQADVIVIM 639
            .:|||:|:..:|..||||.||:|.|:..||..:.:..||:::  .|:||||:||:|..||.|:.|
Zfish   839 CVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAM 903

  Fly   640 DKGKISAMGTYESMAKSGLDFAQ----MLTDPSKKDEGAGDAPDKKSLSRQN------SKLRDRH 694
            ..|.:...||.:.:....::..:    ::....::.|...|...:.:|.|:.      |:....|
Zfish   904 KDGSVLREGTLKDIQTHDVELYEHWKTLMNRQDQELEKDTDLESQTTLERKTLRRAFYSREAKNH 968

  Fly   695 GSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGD 759
            ......|...|. ..:..|.|...| ..:|..|:...|..:.|:    :..|..:.:::......
Zfish   969 VDDEDEEEEVEE-EDDDNMSTTTSR-RSKIPWKMCCCYLSSGGF----LMVFLMVSSKLAKHSVM 1027

  Fly   760 IFLSYWVN--KNGEAERDTFMARLRRAFPETRINADTDPVD-----IYYFTGINVSVIIFSLVRS 817
            :.:.||:.  .:......:|   :..:|..| :|.|...:.     :..|..:..:.|...|:.|
Zfish  1028 VAIDYWLAAWTSSNPHNQSF---VNSSFNHT-LNDDATQIAEHRSYVPVFIILCAAAIALCLITS 1088

  Fly   818 MLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFL 882
            :...:|.:.::|.||:.:...:..|.:.||:..|.|:||||||.|...:|:.:|..:..:.:..|
Zfish  1089 LTVEFLGVAAATNLHHNLLNKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTL 1153

  Fly   883 AIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLAT 947
            ..:..:.|:..:...:::|.|.|.:.||.::.::...|:|::.|:..|:.|:..|.|.:..||.|
Zfish  1154 LCLSAIGVIAFVTPAFLIALVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTT 1218

  Fly   948 IRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYI-AVITLS---FFLFSPEN 1008
            ||||..:...........|.:::.|....|.:|    ||: |...|: |||.|:   ..::|...
Zfish  1219 IRAFRHEARFKQRMLELTDTNNTAYLFLSAANR----WLE-VRTDYLGAVIVLTAAVAAIWSTSP 1278

  Fly  1009 GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPED 1073
            .|.|||.:|.|:.:|..:.|.:|..|:||..|.||::|..:...|.|....|....:.|:|||:.
Zfish  1279 SGLVGLGLTYALTLTNYLNWVVRNLADLEVQMAAVKKVNSFLSTESENYEGSMDVSQVPEDWPQH 1343

  Fly  1074 GKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILI 1137
            |:|...||.::|  |.....||:.:|..|...:||||.||||:|||||..|.|.: ...||.|:|
Zfish  1344 GEITIHDLCVRY--DSMLKPVLKHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVI 1406

  Fly  1138 DRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSG 1202
            |..|...|.|..|||::|||.|:||||||::|.||||....:|.:|||:||..:||.:|..||.|
Zfish  1407 DGIDICKLPLQTLRSRLSIILQDPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGG 1471

  Fly  1203 LQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLT 1267
            |.:.::|||.|||||||||.|||||.:|::.||:||||||::|..|:.::|..:...|.|.||:|
Zfish  1472 LDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVT 1536

  Fly  1268 IAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            |||.:.:::::::|||..:|..||..|...|| ..|..:|..:|:
Zfish  1537 IAHLVSSILEAEQVLVFSSGILVENDSAINLL-AQEDSLFGILVR 1580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	414/1396 (30%)
		ABC_membrane	98..367	CDD:294371	79/302 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	86/230 (37%)
		ABC_membrane	799..1027	CDD:294371	63/231 (27%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	107/221 (48%)
abcc9	XP_005164758.1	CFTR_protein	223..1575	CDD:273530	416/1403 (30%)
		ABC_membrane	304..591	CDD:294371	80/304 (26%)
		ABCC_SUR1_N	678..907	CDD:213257	86/230 (37%)
		ABC_membrane	1045..1300	CDD:294371	69/263 (26%)
		ABCC_SUR2	1269..1583	CDD:213255	137/315 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586000
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650