DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc10

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_005155817.1	Gene:	abcc10 / 556709	ZFINID:	ZDB-GENE-050517-24	Length:	1548	Species:	Danio rerio

Alignment Length:	1394	Identity:	469/1394 - (33%)
Similarity:	713/1394 - (51%)	Gaps:	168/1394 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNIFSSLMFCFAMPTFFKGRKKTLDE-NDLYRALQEHRSDHLGSKLSAAWEK-----EVEKKRKK 75
            |::.|.|::.:..|...:|::..|.. :|::......|:..:..:....|||     .:|:..:.
Zfish   231 SSLLSRLLYLWLNPLLNRGKRGELGRPSDVFELPSRLRTKSVTRRFYQCWEKCLHSRALERPERP 295

  Fly    76 KKTP--------------------------SLLKASMNVFGWR---LAGLGLVLFILEIGFRVTQ 111
            .:.|                          .||:.....||.|   |.||.||..:|..    ..
Zfish   296 DRRPRGNLQDNSWSEAQPERICEGEAEHEVKLLQVLHKAFGLRYYLLGGLKLVASMLAF----AG 356

  Fly   112 PLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMI 176
            ||.|||||.:    ...||...:|....|:|:..::....|..:.::..:..:.::||.|:.|.|
Zfish   357 PLLLGGLVGF----METEGAPLSKGVWCAVGLFASTFLAALLKNIFVYEVSKVALEARAAVISTI 417

  Fly   177 YRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFF 241
            |.|||:::..:|....:|:|||.:|.|..|:.......:.:|..|.:..:..||:|.::|::...
Zfish   418 YCKALKVNAPSLARFNMGEVVNFMSTDTDRVVNFFNSFHEVWSLPFQFVLALYLLYLQVGVAFLG 482

  Fly   242 GVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRT 306
            ||.|.:|.:||...|..:............|.||::|.||:.||:|:|.|.||..|::.|...|.
Zfish   483 GVGVAVLLVPLNKVLASRILENNKHMLQHKDGRVKLMTEILFGIRVLKYYNWEEHFTQKIEEARK 547

  Fly   307 KEMNAIRNVNYIRGT-LQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVY 370
            ||::.::.:.|:... :.::......||: ::.:.:||||..|||.|.|...|...:|...:..
Zfish   548 KELHHLKLLKYLDAVCVYTWAALPVVISI-LTFITYVLLGNNLTAAKVFSTLALVGMLILPLNA- 610

  Fly   371 FPMGISQFAELLVSIRRIQTFMLHEETKVRDKS--------EDLDEQKLGKAGLIAEPTVAQTTG 427
            ||..::...|..||:.|||.|:..::   :|.|        ||             .|:..|.
Zfish   611 FPWVLNGTLEAKVSLDRIQRFLAVQD---QDLSVYYSQVCPED-------------PPSAVQM-- 657

  Fly   428 VLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVL 492
            |....|.:.||...|:.|.....:.........|..::|..|...||.|:|.||.|||||:.|:.
Zfish   658 VQASFSWKQSEEADSVSIPDDITEEGSPPRSFYLHALNLNVKMGSLVVVVGKVGCGKSSLLAAIT 722

  Fly   493 GELNPDSGSVKVNGT---LSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLP 554
            |||....|.|.|.|.   ...|.||||:...||:.|||||...|...|::|::.|||..|..:||
Zfish   723 GELTRCGGEVFVQGREQGFGLAVQEPWIQHATVQDNILFGRDYDNMFYQSVIQACALADDLNILP 787

  Fly   555 YADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEI 619
            ..|:|.|||.|.:||||||:|::||||||...:||||||||:|||..|..||.::|:.|.|:::.
Zfish   788 GGDQTEVGENGVTLSGGQKSRLALARAVYMDKEIYLLDDPLAAVDADVAHHLMEKCILGILKDKT 852

  Fly   620 VLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLS 684
            .:|.||:::|:::|||:|:||.|.|...|     |.|  :...::..|            |.|.:
Zfish   853 RILCTHRIEFVDKADVVVLMDNGMIVKTG-----APS--EVLSLVKGP------------KDSKN 898

  Fly   685 RQNSKLRDRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANG--YGLFIVFAFF 747
            ..|:|.:|..|| ..||::...|.||..|..:|.:..|.:...:|:.|:.|.|  ..:.::.|.|
Zfish   899 SSNAKEKDSAGS-EEMEASEPELKAELEMFGEEQKQMGTLSWAVYRSYWKAVGGCMAVAVLLALF 962

  Fly   748 CIGAQVLASGGDIFLSYWVN--KNGEAE------------------RDTFMARLRRAFPETRINA 792
            .:.|....|  |.:||:|::  |:...|                  |..|.|..|.:.....:::
Zfish   963 LMQASKNVS--DWWLSHWISHMKDNMTELVSVSATPLLMLSFLSPGRLVFNAPARGSESSGNMSS 1025

  Fly   793 DTDPVDIYYFT---GINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGR 854
            :..    :|.|   .:..:..:|:..|:.||.|.|:.::|.:|..:...|.:|.|.||:|.|.||
Zfish  1026 ELK----FYMTVYGSLAAANTVFTAARAFLFAYGAICAATVVHKRLLSSVLKATMTFFDTTPLGR 1086

  Fly   855 ILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLST 919
            ||||||.|:..||:.||.|:..::.....::|:::|:.....|.:|..|.|..::|..:.||..:
Zfish  1087 ILNRFSSDIYSVDDSLPFVLNILLANVFGLLGMLIVMSYGLPWVLLPLVPLGALYYQTQCFYRYS 1151

  Fly   920 SRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGY 984
            ||::|||.::|.||:|||.|.:|:||:|:|..|.....  |.:|.:.:..:...:|  .|.|...
Zfish  1152 SRELKRLCSLTLSPVYSHFSETLSGLSTVRGSGHTTRF--EEENERRLEQNQRCLF--NSNAAMQ 1212

  Fly   985 WLD------CVCVV----YIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENT 1039
            |||      .|.||    .||||........|   |.|||:::.|:.:|.::...:...|:.|..
Zfish  1213 WLDIRLQMIAVTVVTGISVIAVIQHQLKSIDP---GLVGLSLSYALSITNLLSGLIFSYAQTEMQ 1274

  Fly  1040 MTAVERVVEYEDLEPEGDFESKPNKKPPK---DWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIA 1101
            :.::||..||....|:     :|.:...:   .|||..::.|.|:.|.|.|  .....|..:::.
Zfish  1275 LVSIERTEEYSTSIPQ-----EPQQASLEVLDRWPERARVEFVDVVLSYRP--GLPNALDGVSVE 1332

  Fly  1102 IEGCEKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFS 1165
            :...||:|||||||:|||||..||||: ..|:|.||:|..|.:.:.|.|||||::||||:|.|||
Zfish  1333 VLPGEKIGIVGRTGSGKSSLFLALFRMVELNQGQILLDGVDISSVRLSDLRSKLAIIPQDPFLFS 1397

  Fly  1166 GTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILR 1230
            .::|.||||...:.|.:|.|:||:..|..|| ....||.|::.|.|.:.|||||||:|||||:|.
Zfish  1398 SSVRENLDPHGRHPDYRLLEALEQCHLGNVV-QRNGGLDSEVGERGKSLSVGQRQLLCLARALLT 1461

  Fly  1231 ENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSP 1295
            |..||.:|||||:||.:||.|:|.|||.||||.|||||||||:|:|||||||||.|||.|||.||
Zfish  1462 EANILCIDEATASVDQKTDMLLQKTIREKFKDKTVLTIAHRLNTIMDSDKVLVMHAGKVVEFDSP 1526

  Fly  1296 FELLTTSEKKVFHSMVKQTGDSTFDALLK 1324
            ..|.             |..||.|..||:
Zfish  1527 ATLC-------------QREDSAFQKLLR 1542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	463/1368 (34%)
		ABC_membrane	98..367	CDD:294371	78/269 (29%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/202 (45%)
		ABC_membrane	799..1027	CDD:294371	80/240 (33%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	121/221 (55%)
abcc10	XP_005155817.1	SunT	248..1531	CDD:331423	459/1364 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586030
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650