DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc8

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_005170744.1	Gene:	abcc8 / 553281	ZFINID:	ZDB-GENE-050517-22	Length:	1594	Species:	Danio rerio

Alignment Length:	1434	Identity:	441/1434 - (30%)
Similarity:	710/1434 - (49%)	Gaps:	185/1434 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IFSSLMFCFAMPTFFKGRKKTLDENDL-YRALQE-----HRSDH--LGSKLSAAWEKEVEKKRKK 75
            |||....|||..|..|..:   |..|| .|.||.     .:|.:  :.:.:::|..:.::.| ..
Zfish   203 IFSRRYMCFAHATEVKPPE---DLQDLGVRFLQPFVNLLSKSTYWWMNTFITSAHRRPIDLK-VI 263

  Fly    76 KKTPSLLKASMNVFGWRLA--------------------------GLGLVLFILE------IGFR 108
            .:.|..::|..|....|.|                          |..|:|.|..      :||
Zfish   264 GRLPIAMRALTNYIKLRQAFEAQKGPQDTPPQGSKWIWAALRQAFGKPLILSITYRFMADLLGF- 327

  Fly   109 VTQPLFLGGLVAYYADASNQEGDNQT---------------KAYL---YALGVILTSACNVLFMH 155
             ..||.:.|:|.:.:.      :|.|               :.:|   |.|.|:|..|  :|...
Zfish   328 -AGPLCISGIVHHLSK------ENHTILPPVKHLGMYFISSQEFLANGYVLAVLLFFA--LLLQR 383

  Fly   156 PYMLGMFHI----GMKARIAMTSMIYRKALRL--SRTALGDTTIGQVVNLISNDVGRLDVSVIHM 214
            .::...:::    |:..|.|:.:.|:.|.:||  |..::|..|:||:.||::.|..:|.......
Zfish   384 TFLQASYYVAIETGINLRGAIQTKIFNKIMRLCTSNLSMGGMTVGQICNLVAIDTNQLMWFFFLC 448

  Fly   215 NYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMN 279
            ..|:..||:|.:...|:|..:||||..|..::.|..|:|.::..|.|..:..|...:.||::..|
Zfish   449 PNLFAMPVQIIVGIILLYYLLGISALIGATIITLLAPVQYFVATKLSDAQKSTLEYSSERLKKTN 513

  Fly   280 EIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS------- 337
            |::.||:::|:||||..|...:...|.||:.          :||:|.:: |.||:|::
Zfish   514 ELLRGIKLLKLYAWEHIFCSNVEETRCKELT----------SLQAFALY-TSISIFMNTAIPIAA 567

  Fly   338 -LVGFVLLGKL-----LTAEKAFVITAYYNILRNTMTVYFPMG--ISQFAELLVSIRRIQTFMLH 394
             ||.||....|     |:...||...:.::||   :|..|.:.  :....:.|||::::..|...
Zfish   568 VLVTFVAHVHLSDDADLSPAVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFFSC 629

  Fly   395 EE---------TKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSE----AEHSIVIS 446
            :|         |.|.:.:.....|.|....:..:..|.:........|.:..|    .:..|.|.
Zfish   630 DEIGGEQEPRATVVPNSTNHNKYQALPLKVVNRKRPVREDWNSFALQSEQEDEVLAVGDEDICIK 694

  Fly   447 KLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELN--------------- 496
            .....:......:||.|:::|....||..::|.||.|||||:.|.|||:.
Zfish   695 ITNGYFSWTEGTSTLSNVNIKIPFGQLTMIVGQVGCGKSSLLLAALGEMQKISGTVIWNRMPTLD 759

  Fly   497 -------PDS---GSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFE 551
                   ||:   |.::..|.::||||:|||...|:.:||.|.:|:.|.|||.|::.|:|:.|.:
Zfish   760 AEGNESLPDAAAEGDIRKRGAVAYASQKPWLLNTTLAENITFEMPLIKQRYRAVIEACSLQPDID 824

  Fly   552 LLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLR 616
            :||..|:||:||||..|||||:.|||:|||:|:..::..||||.||:|.|:..||..:.:...||
Zfish   825 ILPQGDQTIIGERGIILSGGQRQRISVARALYQTTNVVFLDDPFSALDIHLSDHLMQEGILKLLR 889

  Fly   617 EE--IVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLD-FAQMLTDPSKKD-EGAGDA 677
            ||  .|::|||:||:|..||.|:.|..|.|...||.:.:.||..: |.|..|...::| |...:.
Zfish   890 EEKRTVVIVTHKLQYLPHADWIIAMKDGSIQTEGTLKDIQKSQPELFEQWKTLMHRQDKEFEKET 954

  Fly   678 PDKKS--LSRQNSK--LRDRHGSISSMESAAESLAAESPMQ-TQEGRVEGRIGMKLYKKYFGANG 737
            .|:..  |.|:|.:  :..|....:..:...|||.::.... :|..|....|..:....|..:.|
Zfish   955 VDENMTVLERKNLRRAMYSREALKTEEDEEEESLESDDDDNLSQVMRHRATIPWRSCGTYLSSAG 1019

  Fly   738 YGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINAD---TDPVDI 799
            ..|.::.....:....|....|.:|::|.:|       ...|::..|.....:..|   |....:
Zfish  1020 LLLLLLLLLSQLLKHSLLVAIDYWLAHWTSK-------VITAKIDAAAHNCSLVQDIGFTHSSYL 1077

  Fly   800 YYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLG 864
            ..|:.:....|:..|..|:...:..:|.:..||:.:...:..|.|..|.|.|.|.||||||.|..
Zfish  1078 LVFSLLCCLGIVLCLATSVAVEWTGLRVAKELHHNLLSNIILAPMRLFETTPLGSILNRFSSDTN 1142

  Fly   865 QVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAV 929
            .:|:.:|:.:..:.:..|..|..:.|:..:...:::....|.|..|.::.::...|:|:::||..
Zfish  1143 TIDQHIPATLECLSRSTLLCVSALGVISYVTPVFLIVLAPLTIACYFIQKYFRVASKDLQQLEDS 1207

  Fly   930 TRSPIYSHLSASLNGLATIRAFGAQ---KELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDC--- 988
            |:.|:.||.|.::.||.|||||..:   ::.:.:|.:..:|.|    :||.   |...||:.
Zfish  1208 TQLPLLSHFSETVEGLTTIRAFRYEPRFRQRLLQFTDANNMAS----LFLT---AANRWLEVRME 1265

  Fly   989 ---VCVVYI-AVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY 1049
               .|:|.| ||.:::..|:|..:.|.|||.:|.|:.::..:.|.:|..|::|..:.||:|:...
Zfish  1266 YIGACIVLIAAVASITNSLYSHLSTGLVGLGLTYALMVSNYLNWMVRNLADMEVQLGAVKRIKAL 1330

  Fly  1050 EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRT 1114
            ...|||.........:.|:.||:.|:|...:||::|  |.....||:.:|..|:..:|:||.|||
Zfish  1331 LRTEPENYEGLLSASQVPEGWPQQGEIQIQNLSVRY--DSTLKPVLKHVNAHIKPGQKLGICGRT 1393

  Fly  1115 GAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEY 1178
            |:||||...|.||: ...||.|:||..|...|.|..|||:.|||.|:|.|||||:|:||||..:.
Zfish  1394 GSGKSSFSLAFFRMVDTFEGRIIIDDIDIAKLPLQTLRSRFSIIQQDPFLFSGTIRFNLDPEMKA 1458

  Fly  1179 SDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATAN 1243
            :|:.|||:||..:||.||..||.||.:.|:|||.|||.|||||.|||||.:|::.||:||||||:
Zfish  1459 TDSMLWEALEIAQLKPVVKTLPGGLDAIITEGGENFSQGQRQLFCLARAFVRKSSILIMDEATAS 1523

  Fly  1244 VDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFH 1308
            :|..|::::|..:...|.|.||:|||||:||::::|.|:||..|..:||..| |:|...|..||.
Zfish  1524 IDMATESILQKVVMTAFADRTVVTIAHRVHTILNADLVIVMKRGVILEFDKP-EVLLDQEDSVFA 1587

  Fly  1309 SMVK 1312
            |.|:
Zfish  1588 SFVR 1591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	435/1420 (31%)
		ABC_membrane	98..367	CDD:294371	83/311 (27%)
		ABCC_MRP_domain1	443..643	CDD:213217	90/226 (40%)
		ABC_membrane	799..1027	CDD:294371	65/237 (27%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	111/221 (50%)
abcc8	XP_005170744.1	MRP_assoc_pro	39..1591	CDD:188098	440/1432 (31%)
		ABC_membrane	<388..603	CDD:294371	66/228 (29%)
		P-loop_NTPase	693..918	CDD:304359	89/224 (40%)
		ABC_membrane	1038..1307	CDD:279056	73/282 (26%)
		P-loop_NTPase	1355..1594	CDD:304359	119/240 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650