Protein Alignment CG4562 and AgaP_AGAP004600

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_001237640.2
• Gene: AgaP_AGAP004600 / 4576814
• VectorBaseID: AGAP004600
• Length: 1011
• Species: Anopheles gambiae
• Alignment Length: 1158
• Identity: 410/1158 - (35%)
• Similarity: 623/1158 - (53%)
• Gaps: 222/1158 - (19%)

  Fly   155 HPYMLGMFHIGMKARIA----------MTSMIY------------------RKALRLSRTALGDT 191
            |||.|.....|...|:.          :|.:.|                  |..:.|.....||.
Mosquito    11 HPYELLQRTDGALKRLVDGMEESTAQQLTGIAYQAYGKRLTQPSSTPNGSNRAKMILCMNNAGDG 75

  Fly   192 TIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYL 256
            ..|.|:||::|||.|.|.:||..:.||.||||:.|:..|:|||||.:...|:..:|||||:||:|
Mosquito    76 LSGTVINLMANDVSRFDYAVIFFHDLWKGPVELVIVAVLVYREIGPAGLIGIGFLLLFIPIQAWL 140

  Fly   257 GKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGT 321
            ||:::..|:|.||.||||||:.|||:.||||||||.||.||.:|...:||||:.|:|....|:..
Mosquito   141 GKQSARFRMKAALATDERVRLTNEIVHGIQVIKMYVWEKPFEQMARKLRTKEIKALRGSAIIKSA 205

  Fly   322 LQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIR 386
            |.: :..|.::|:|::||.:|..|..|||.:.:::.::::::.::|..::|:.::..||..:|::
Mosquito   206 LFA-LRIVPKVSIFLTLVAYVYFGNALTARRVYMLISFFSVIHHSMVEFWPLAVTSAAEGWISLK 269

  Fly   387 RIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHS-----IVIS 446
            |||.|:..|  .|||..:..:                             |...|:     :...
Mosquito   270 RIQQFLFEE--NVRDHGKQAE-----------------------------SRCPHADVPPYVEFK 303

  Fly   447 KLKAKWDQKNTDNTLDNISLKFK--PRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLS 509
            .:...|  .|::.:|.:.|.:.:  ..:..|:|||:|:|||:|:..|:||.:...|::.||||:|
Mosquito   304 NVHTSW--PNSNFSLQDASFRVEATAHRTAAIIGPIGAGKSTLLNLVIGEQSATHGTITVNGTVS 366

  Fly   510 YASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKA 574
            |.||:||||.|||:||::|....|:.|||||||.||||.|.:..|:.|:|:|||||.||||||||
Mosquito   367 YCSQKPWLFEGTVQQNVIFVDTYDETRYRTVVKICALEHDIQTWPHGDQTMVGERGYSLSGGQKA 431

  Fly   575 RISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIM 639
            ||:||||:||:||||||||||:|||.|:...:|:|.:|.||::::.:||||||:::.|.:.|:::
Mosquito   432 RINLARALYRRADIYLLDDPLAAVDAHIANVIFEQAIRDFLQDKLCMLVTHQLKYIHQVEHIIVL 496

  Fly   640 DKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSL---SRQNSKLRDRHGSISSME 701
            :.|||::.|.|...........|:     .||:   .||..|.|   .:...::|       ..:
Mosquito   497 EDGKITSQGHYSKELSEWFTSHQL-----SKDQ---KAPMDKMLECVEKDEPQVR-------RTD 546

  Fly   702 SAAESLAAESPMQTQEGRVEGRIGMKLYKKYF-GANGYGLFIVFAFFCIGAQVLASGGDIFLSYW 765
            :..::|.||  ...:||:.:|.:..|:|..:. ..|...:....|...||.|..:||.|.|:..|
Mosquito   547 TQEQTLPAE--RNVKEGQEDGTVEFKVYIDFLKSVNSIPIVAFTALLMIGYQAASSGTDYFVFIW 609

  Fly   766 VNKNGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTT 830
            |:     ..:||...:...:        |....::::||..|..|:.: ..|..||.:.:::|..
Mosquito   610 VD-----WEETFSNTVHALW--------TTDDHVWFYTGAIVITIMLT-TNSFAFFEMCLKASLH 660

  Fly   831 LHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMD------------------- 876
            ||..:::|||...|.||..|||||::||||||:|.:|..||:||:|
Mosquito   661 LHAALYRGVTETVMAFFYQNPSGRVMNRFSKDIGLIDTSLPTVMIDSLYVRNLHLRFCIRVLNPA 725

  Fly   877 -VMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSA 940
             .:|.||.:.||:|::.:.|.|.::.|..:.:||||||..:|..:|:|||:||::
Mosquito   726 KYLQFFLELSGIIVIVALANYWLLIPTAIMGVVFYLLRGVFLRAARNVKRVEAIS---------- 780

  Fly   941 SLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFS 1005
                                                          :|...||
Mosquito   781 ----------------------------------------------ECDGNVY------------ 787

  Fly  1006 PENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKP---P 1067
              :.|:|||||||.:.:.||..||:||:|||||.||:||||.||..|.||.|.  .|..:.   .
Mosquito   788 --HVGNVGLAITQVLNLIGMCNWGIRQTAELENQMTSVERVFEYAQLGPEPDL--APGVQTIVRN 848

  Fly  1068 KDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLS--- 1129
            :.|||:..|.|.::.|:|.|  .|:.||:.|:..|:.                  .|||||:
Mosquito   849 EAWPENASITFREVYLRYSP--TAEPVLKRLSFTIKA------------------KALFRLTPLH 893

  Fly  1130 YNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQ 1194
            ..:|:|.||..:...:.|...|..||||||:||:|||::|.||||.:...|.:||::|::|:||.
Mosquito   894 AGDGSIEIDGINIGSVPLRQSRGLISIIPQDPVIFSGSLRSNLDPEERLPDEELWKALDQVELKT 958

  Fly  1195 VVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1247
            .::....||.:|:.|||||.|.|||||:|||||||:.::||::|||||||||:
Mosquito   959 TISTFAGGLNTKMMEGGTNLSAGQRQLICLARAILKGSKILILDEATANVDPR 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	410/1158 (35%)
		ABC_membrane	98..367	CDD:294371	91/239 (38%)
		ABCC_MRP_domain1	443..643	CDD:213217	99/201 (49%)
		ABC_membrane	799..1027	CDD:294371	69/247 (28%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	76/177 (43%)
AgaP_AGAP004600	XP_001237640.2	ABC_membrane	<77..246	CDD:294371	79/169 (47%)
		EcfA2	300..505	CDD:224047	102/206 (50%)
		ABCC_MRP_domain1	300..500	CDD:213217	99/201 (49%)
		MdlB	583..1011	CDD:224055	182/533 (34%)
		ABC_membrane	617..>780	CDD:294371	57/171 (33%)
		P-loop_NTPase	856..>1010	CDD:304359	74/173 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830