Protein Alignment Mrp5 and Cftr

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 1441
• Identity: 606/1441 - (42%)
• Similarity: 845/1441 - (58%)
• Gaps: 196/1441 - (13%)

  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKK 75
            :|||:.:||.|.|:|.:|:|..::|.::.|:.:||.:.|:|.||:.||.:|...|.||:|:..:|
  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74

  Fly    76 KKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYY------------------ 122
            |:.|.|..|....|.......||:.||. |..:...|..|..|:..:
  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIY-IVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138

  Fly   123 --------------------ADASNQEGD----------------------------------NQ 133
                                |::|...||                                  :|
  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203

  Fly   134 TKAYLY----ALGVIL---TSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDT 191
            |..:::    :||.:|   |..|..| :|...|....:|.:.|||..|:||||.||||....|.|
  Fly   204 TVEHMWNDMNSLGAVLVLSTLFCCFL-LHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQT 267

  Fly   192 TIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLL-FIPLQAY 255
            ..|.::||:||||.|||...|.|:::|:.|::..:..||::..|||.|..||..:|| .:|:|..
  Fly   268 PAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTA 332

  Fly   256 LGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG 320
            |.|.|||||::.|.|||.||.:|||::.|||||||||||.||..::...|..|:..||..:|:||
  Fly   333 LSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRG 397

  Fly   321 TLQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSI 385
            ...|.::|..|.:::::|....|:|:.:||:..|...:|||||:....:::|:.:|..||.|||:
  Fly   398 FYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSL 462

  Fly   386 RRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEA--EHSIVISKL 448
            ||||.|::.|..:.|                        |.|:   :.:|..|.  ..::.|..:
  Fly   463 RRIQDFLMLEGREER------------------------TQGL---THKRDQEGGDSRAVTIKDI 500

  Fly   449 KAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQ 513
            .|.||.:....||.:|:|:.:..||.|||||||:||||::|.:||||....|.|.:.|.||||:|
  Fly   501 NASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQ 565

  Fly   514 EPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISL 578
            |||||||:||.|||||...|:.||:.|.:.|||..||:.||..|||:||||||||||||:|||||
  Fly   566 EPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISL 630

  Fly   579 ARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLRE--EIVLLVTHQLQFLEQADVIVIM 639
            |||||:.|.|||:||||||||.||||||||:.:  ||.|.:  ...:|||||:.||.:||||||:
  Fly   631 ARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIV 695

  Fly   640 DKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAA 704
            |:|:|...|||:.:..|.||||::|..|.:::||            :||:.:....|::|:||..
  Fly   696 DQGRILRQGTYQELINSDLDFARLLERPKEEEEG------------ENSRNQTSPLSVNSLESDD 748

  Fly   705 ESL---------------------AAESPMQTQ-----------EGRVEGRIGMKLYKKYFGANG 737
            |.:                     .::|...||           |.:..|.|..:::.:||.|..
  Fly   749 EDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGS 813

  Fly   738 YGL-FIVFAFFCIGAQVLASGGDIFLSYWVNK-----NGEAERDTFMARLRRAFPETRINADTDP 796
            ..| |....|..:.:||:.|..|.|.:.|..:     .|||...||..
  Fly   814 TLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFEC----------------- 861

  Fly   797 VDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSK 861
              :|.:..:.::|:|.:..|..|||.:.|.:|..||:.||..:..|.|.||:|.|||||||||||
  Fly   862 --MYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSK 924

  Fly   862 DLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRL 926
            |:|.:||:||..|||.:||.|.:.||::|:.|:|...:.|.:.:.:|..|:...||..|:|:|||
  Fly   925 DMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRL 989

  Fly   927 EAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCV 991
            |.:.|||::|||||||.|||.||:...|..:..|||..||:|||.:.:.:|.:...|.|||||..
  Fly   990 EGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSC 1054

  Fly   992 VYIAVITLSFFLFSPEN-GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPE 1055
            :::..:|.||.:.|... .|:|||||.|||.:|||||:|:||.||....||:||||::|.:||.|
  Fly  1055 IFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE 1119

  Fly  1056 GDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSS 1120
               .:...|.||:.||..|::.|.::|.:|.|:.:.  |||:||:.||...||||||||||||||
  Fly  1120 ---PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSP--VLRNLNLTIEAGWKVGIVGRTGAGKSS 1179

  Fly  1121 LINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWE 1185
            ||.|||||::.||.|.||..:|..:.|..||::||||||:|||||.|:|||||||:.|:||:||.
  Fly  1180 LIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWS 1244

  Fly  1186 SLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDA 1250
            :||:|:|::.:    .||...::|.|.|||||||||:||||||||.|::||:|||||||||||||
  Fly  1245 ALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDA 1305

  Fly  1251 LIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |||.|||.|||.|||||:|||||||||||:::|||||.||||..|:.||..|:..: ..||:.||
  Fly  1306 LIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATG 1369

  Fly  1316 DSTFDALLKVA 1326
            ..: :||.|.|
  Fly  1370 GES-EALKKTA 1379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	573/1360 (42%)
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	596/1412 (42%)