DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4562 and CG5789

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_001247286.1 Gene:CG5789 / 42928 FlyBaseID:FBgn0039207 Length:1402 Species:Drosophila melanogaster


Alignment Length:1441 Identity:606/1441 - (42%)
Similarity:845/1441 - (58%) Gaps:196/1441 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 ENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKK 75
            :|||:.:||.|.|:|.:|:|..::|.::.|:.:||.:.|:|.||:.||.:|...|.||:|:..:|
  Fly    10 KNPRQHANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSHRK 74

  Fly    76 KKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYY------------------ 122
            |:.|.|..|....|.......||:.||. |..:...|..|..|:..:                  
  Fly    75 KQKPHLRNALFRCFLGPTIINGLICFIY-IVIKTLIPAVLAQLLIQFQKTPVAQLRNIDVNDISI 138

  Fly   123 --------------------ADASNQEGD----------------------------------NQ 133
                                |::|...||                                  :|
  Fly   139 SDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAGPLEPIQPPVEEVDHNATAVRSILDQ 203

  Fly   134 TKAYLY----ALGVIL---TSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDT 191
            |..:::    :||.:|   |..|..| :|...|....:|.:.|||..|:||||.||||....|.|
  Fly   204 TVEHMWNDMNSLGAVLVLSTLFCCFL-LHHVDLRQRLMGARMRIACCSLIYRKTLRLSMKTAGQT 267

  Fly   192 TIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLL-FIPLQAY 255
            ..|.::||:||||.|||...|.|:::|:.|::..:..||::..|||.|..||..:|| .:|:|..
  Fly   268 PAGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPVQTA 332

  Fly   256 LGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG 320
            |.|.|||||::.|.|||.||.:|||::.|||||||||||.||..::...|..|:..||..:|:||
  Fly   333 LSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIRYASYLRG 397

  Fly   321 TLQSFIMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSI 385
            ...|.::|..|.:::::|....|:|:.:||:..|...:|||||:....:::|:.:|..||.|||:
  Fly   398 FYLSTMVFTERSTLYITLAAAALMGQTITADFVFSAASYYNILQLVAAIWYPLAVSFGAEALVSL 462

  Fly   386 RRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEA--EHSIVISKL 448
            ||||.|::.|..:.|                        |.|:   :.:|..|.  ..::.|..:
  Fly   463 RRIQDFLMLEGREER------------------------TQGL---THKRDQEGGDSRAVTIKDI 500

  Fly   449 KAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQ 513
            .|.||.:....||.:|:|:.:..||.|||||||:||||::|.:||||....|.|.:.|.||||:|
  Fly   501 NASWDIEKPQKTLQSINLQIEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQGDLSYAAQ 565

  Fly   514 EPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISL 578
            |||||||:||.|||||...|:.||:.|.:.|||..||:.||..|||:||||||||||||:|||||
  Fly   566 EPWLFTGSVRNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISL 630

  Fly   579 ARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLRE--EIVLLVTHQLQFLEQADVIVIM 639
            |||||:.|.|||:||||||||.||||||||:.:  ||.|.:  ...:|||||:.||.:||||||:
  Fly   631 ARAVYKPAQIYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIV 695

  Fly   640 DKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAA 704
            |:|:|...|||:.:..|.||||::|..|.:::||            :||:.:....|::|:||..
  Fly   696 DQGRILRQGTYQELINSDLDFARLLERPKEEEEG------------ENSRNQTSPLSVNSLESDD 748

  Fly   705 ESL---------------------AAESPMQTQ-----------EGRVEGRIGMKLYKKYFGANG 737
            |.:                     .::|...||           |.:..|.|..:::.:||.|..
  Fly   749 EDIPFIDGVKDGYQQLRKQSSSVHGSKSLDSTQLDDNVDEDDLAEAQASGGISPRVWYEYFHAGS 813

  Fly   738 YGL-FIVFAFFCIGAQVLASGGDIFLSYWVNK-----NGEAERDTFMARLRRAFPETRINADTDP 796
            ..| |....|..:.:||:.|..|.|.:.|..:     .|||...||..                 
  Fly   814 TLLSFSFMVFVMVMSQVVCSSSDFFANIWTQQEHQRSQGEATFSTFEC----------------- 861

  Fly   797 VDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSK 861
              :|.:..:.::|:|.:..|..|||.:.|.:|..||:.||..:..|.|.||:|.|||||||||||
  Fly   862 --MYIYGALIIAVVIMTTFRGFLFFKICMHASKVLHDRMFACILHATMRFFDTTPSGRILNRFSK 924

  Fly   862 DLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRL 926
            |:|.:||:||..|||.:||.|.:.||::|:.|:|...:.|.:.:.:|..|:...||..|:|:|||
  Fly   925 DMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVAVVDVLILKLYLRPSQDLKRL 989

  Fly   927 EAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCV 991
            |.:.|||::|||||||.|||.||:...|..:..|||..||:|||.:.:.:|.:...|.|||||..
  Fly   990 EGICRSPVFSHLSASLTGLAIIRSRQLQDVVAKEFDLLQDVHSSVWQLTMAVNTTLGLWLDCVSC 1054

  Fly   992 VYIAVITLSFFLFSPEN-GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPE 1055
            :::..:|.||.:.|... .|:|||||.|||.:|||||:|:||.||....||:||||::|.:||.|
  Fly  1055 IFLTSVTFSFIISSETTYSGNVGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQYTELEQE 1119

  Fly  1056 GDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSS 1120
               .:...|.||:.||..|::.|.::|.:|.|:.:.  |||:||:.||...||||||||||||||
  Fly  1120 ---PALGEKTPPQQWPTRGQVEFRNMSCRYDPNGSP--VLRNLNLTIEAGWKVGIVGRTGAGKSS 1179

  Fly  1121 LINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWE 1185
            ||.|||||::.||.|.||..:|..:.|..||::||||||:|||||.|:|||||||:.|:||:||.
  Fly  1180 LIGALFRLAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFERYTDAELWS 1244

  Fly  1186 SLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDA 1250
            :||:|:|::.:    .||...::|.|.|||||||||:||||||||.|::||:|||||||||||||
  Fly  1245 ALEDVELRKAI----PGLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEATANVDPQTDA 1305

  Fly  1251 LIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |||.|||.|||.|||||:|||||||||||:::|||||.||||..|:.||..|:..: ..||:.||
  Fly  1306 LIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGHL-RQMVEATG 1369

  Fly  1316 DSTFDALLKVA 1326
            ..: :||.|.|
  Fly  1370 GES-EALKKTA 1379

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 596/1412 (42%)
ABC_membrane 98..367 CDD:294371 112/348 (32%)
ABCC_MRP_domain1 443..643 CDD:213217 121/203 (60%)
ABC_membrane 799..1027 CDD:294371 104/228 (46%)
ABCC_MRP_domain2 1074..1295 CDD:213211 141/220 (64%)
CG5789NP_001247286.1 CFTR_protein 9..1367 CDD:273530 600/1426 (42%)
ABC_membrane 214..441 CDD:294371 98/227 (43%)
ABCC_MRP_domain1 495..699 CDD:213217 121/203 (60%)
ABC_membrane 863..1088 CDD:294371 101/224 (45%)
ABCC_MRP_domain2 1135..1350 CDD:213211 141/220 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 86 1.000 Domainoid score I2776
eggNOG 1 0.900 - - E2759_KOG0054
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 133 1.000 Inparanoid score I246
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - P PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X771
109.870

Return to query results.
Submit another query.