DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_956883.2	Gene:	abcc2 / 393561	ZFINID:	ZDB-GENE-040426-1523	Length:	1567	Species:	Danio rerio

Alignment Length:	1441	Identity:	506/1441 - (35%)
Similarity:	797/1441 - (55%)	Gaps:	211/1441 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ADELPE-------NPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDH------- 56
            ||..||       ||..|:...|.:.|.:.....:||.|:.|.:.|:: .|.::.|.|
Zfish   194 ADVSPEAKKVAETNPEAKATFLSRITFNWFNSMVWKGFKRPLVQEDMW-DLNKNDSTHFICQTFE 257

  Fly    57 --LGSKLSAA-------------------------------------WEKEVEKKRKKKKTPS-- 80
              :..:|..|                                     .|||.:||:|||:..|
Zfish   258 DVMAKELKKARNNLQKKKSKKRKTVDAEGQNGLAKGVSQDVLVMETETEKESKKKKKKKQKDSDS 322

  Fly    81 ----------LLKASMNVFGWRLAGLGLVLF-ILEIGFRVTQPLFLGGLVAYYADASNQEGDNQT 134
                      ::|:...|.      |...|| :|:.......|..|..::|:     .|..|:..
Zfish   323 DYPQSWLVTTIVKSFKGVL------LESALFKLLQDLLSFASPQLLKLMIAF-----TQNKDSYA 376

  Fly   135 -KAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVN 198
             ..||||:.::|.:....:.:..|....|.:|||.|.|:.:.:|:|||.:|..:..::|.|::||
Zfish   377 WTGYLYAVLLVLVAFVQSVVLQQYFQRCFILGMKVRTAIMAAVYKKALVVSNDSRKESTAGEIVN 441

  Fly   199 LISNDVGRLD--VSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTS 261
            |:|.|..|.:  .:.||:  ||..|::|.:....::.|:|.|...|:.||:|.:|:..:|..|:.
Zfish   442 LMSADAQRFNDVTNFIHL--LWSCPLQIALSIAFLWIELGPSVLSGLLVMVLMVPINGWLATKSR 504

  Fly   262 VLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFI 326
            ..:::.....|.|::::|::::||:::|.||||..|...:..:|.||:..:|...|: .::.:||
Zfish   505 QFQMQNMKFKDSRMKIVNDLLNGIKILKYYAWETSFEAQVQEIREKELKVMRKFAYL-SSVSTFI 568

  Fly   327 -------MFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVS 384
                   :.:...:||||    |....:|.|||||...:.:||||..:.: .|..||...:..||
Zfish   569 FSCAPALVSLATFAVFVS----VSPDNILDAEKAFTSISLFNILRFPLAM-LPQLISIMVQTSVS 628

  Fly   385 IRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLK 449
            .:|::.|:         ..:|||                 ||.|...||     ...::.::...
Zfish   629 KKRLEKFL---------SGDDLD-----------------TTTVTHDSS-----ITAAVSMTNGT 662

  Fly   450 AKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQE 514
            ..| :::|:..|..:||..||.:||||:|.|||||:||:.|:||||:...|::.:||:::|..|:
Zfish   663 YAW-ERDTEPVLKRVSLDIKPGRLVAVVGAVGSGKTSLVSALLGELHSIKGNININGSVAYVPQQ 726

  Fly   515 PWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLA 579
            .|:...|::.|||||..:|:.||::|:|.|||..|.:|||..|:|.:||:|.:||||||.|:|||
Zfish   727 AWIQNATLKDNILFGSSVDEERYQSVIKACALGPDLDLLPGRDQTEIGEKGINLSGGQKQRVSLA 791

  Fly   580 RAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKG 642
            ||||..||:|||||||||||:|||:|||::.:  .|.||::..:|:||.:.||...|.||::..|
Zfish   792 RAVYSSADVYLLDDPLSAVDSHVGKHLFEKVIGPNGLLRDKTRILITHGISFLPYVDEIVVLVHG 856

  Fly   643 KISAMGTYESMAKSGLDFAQML----TDPSKKD--------------------EG----AGDAPD 679
            .:|.:|:|||:..|...|::.|    .|.|.||                    ||    |..:|:
Zfish   857 VVSEIGSYESLRASKGAFSEFLETYGKDESNKDNDKKAAAAQTPVYEEIETLPEGLETQADGSPE 921

  Fly   680 ---KKSLSRQNSKLR------DRHGSISSMESAAESLAAESPMQTQEGR--VE------GRIGMK 727
               ..:|.|:|| ||      .|:||:...:::  ||.|:...:.::|:  :|      ||:...
Zfish   922 DIVSSTLKRENS-LRHSQRHSKRNGSVKVRKNS--SLRAQKDPEDKKGQRLIEKEMMETGRVKFS 983

  Fly   728 LYKKYFGANGY---GLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETR 789
            :|.:|..|.|:   |...||.|.   ..|...|.:::||.|.:.:.|....|:...:|    :||
Zfish   984 VYLQYLSAMGWWYVGFSFVFYFI---QNVAVIGQNLWLSDWTDDSIEYFNQTYPNHIR----DTR 1041

  Fly   790 INADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGR 854
            |.       ::...|:....::|  ..::|....::.:|.|||.::...:.:..|.||:|.||||
Zfish  1042 IG-------VFGALGLAQGFLVF--FGTILLADGSISASRTLHTSLLTNILKVPMMFFDTTPSGR 1097

  Fly   855 ILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLST 919
            |:|||:||:..|||::|......:...|.::|.:.|:|:....:....|.:.:|:|.::.||::|
Zfish  1098 IVNRFAKDIFTVDEMIPMSFRSWILCLLGVLGTLFVICLATPIFTAVVVPMAVVYYFVQRFYVAT 1162

  Fly   920 SRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGY 984
            ||.::||::|:|||||||...:::||:.|||:|.|...:...::..|.:....|.::.::|....
Zfish  1163 SRQLRRLDSVSRSPIYSHFGETVSGLSVIRAYGHQDRFLKRNEHTIDQNLKSVYPWIVSNRWLAM 1227

  Fly   985 WLDCV--CVVYIAVITLSFFLFSPE--NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVER 1045
            .|:.:  .||:.|.:   |.:.|.:  |.|.|||:|:.|:.:|..:.|.:|.::|||..:.||||
Zfish  1228 RLESLGNLVVFFAAL---FAVISRDSLNSGLVGLSISYALNVTQTLNWLVRMTSELETNIVAVER 1289

  Fly  1046 VVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGI 1110
            |.||.:::.|..:.:  :.:||.|||..|.|.|:|..::|.|:  .:.||..:...|:..||:||
Zfish  1290 VREYAEIQNEAPWVT--SVRPPDDWPSAGNIRFEDYKVRYRPE--LELVLHGVTCDIQSTEKIGI 1350

  Fly  1111 VGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDP 1174
            |||||||||||.|.|||: ...:|.||||..|...||||||||:::||||:|||||||:|.||||
Zfish  1351 VGRTGAGKSSLTNCLFRIVEAADGRILIDDIDIATLGLHDLRSRLTIIPQDPVLFSGTLRMNLDP 1415

  Fly  1175 FDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1239
            |..:|||::|..||...||:.|..||:||:.::||||.|.|:|||||:|||||:||::|||::||
Zfish  1416 FQTFSDAEIWSVLELAHLKEYVRGLPTGLEHEVSEGGENLSLGQRQLLCLARALLRKSRILILDE 1480

  Fly  1240 ATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEK 1304
            |||.||.:||.|||:|||.:|..||||||||||:|::||.:|:|:|:||.|||.||.|||  |:.
Zfish  1481 ATAAVDLETDDLIQSTIRREFSHCTVLTIAHRLNTILDSSRVMVLDSGKIVEFDSPNELL--SKP 1543

  Fly  1305 KVFHSMVKQTG 1315
            ..|.||.:..|
Zfish  1544 GHFSSMAEDAG 1554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	496/1411 (35%)
		ABC_membrane	98..367	CDD:294371	82/279 (29%)
		ABCC_MRP_domain1	443..643	CDD:213217	97/201 (48%)
		ABC_membrane	799..1027	CDD:294371	71/231 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	130/221 (59%)
abcc2	NP_956883.2	MRP_assoc_pro	10..1555	CDD:188098	506/1441 (35%)
		ABC_membrane	346..612	CDD:294371	82/277 (30%)
		ABCC_MRP_domain1	656..856	CDD:213217	97/200 (49%)
		ABC_membrane	1001..1270	CDD:279056	85/287 (30%)
		ABCC_MRP_domain2	1316..1536	CDD:213211	130/221 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.660