DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and CG10505

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:NP_611571.2 Gene:CG10505 / 37428 FlyBaseID:FBgn0034612 Length:1312 Species:Drosophila melanogaster


Alignment Length:1347 Identity:577/1347 - (42%)
Similarity:830/1347 - (61%) Gaps:86/1347 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 NPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRKKK 76
            ||..|:||.|..:|.:....|.|||::.||.:.||..|....|:.|...|...||||     .||
  Fly    14 NPFIKANIISKWLFLWMHSVFRKGRREELDASKLYEHLPSFDSESLTRNLQPHWEKE-----SKK 73

  Fly    77 KTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYAL 141
            |.|||::....|:||:...:.::..:||:.....|||.||||::|:  |..|....:..|||||:
  Fly    74 KNPSLMRLIFKVYGWQFVPVCILYSLLEMAIHSFQPLLLGGLISYF--AYGQTTVTKESAYLYAM 136

  Fly   142 GVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGR 206
            |::|.|....|..||:|..:|.:|.:.|:|...::|||.||.|.:: |:...||.::::|.|:.:
  Fly   137 GIVLCSLVTSLVFHPFMFYVFAVGTRVRLACAGLVYRKCLRASASS-GEGLGGQAISVMSIDLSQ 200

  Fly   207 LDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRT 271
            .|::....:.||.||||..|..|||.|::|.::..|:|.:::.|||||:..|.::....::|...
  Fly   201 FDLTFYFFHDLWKGPVEACIFGYLMTRQVGWTSLIGIAFIVILIPLQAWAAKASASFGTRSAKHR 265

  Fly   272 DERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFV 336
            |.||::|||||..||||||||||..|.::|..||..|:.|||....|...||...| :::||:|:
  Fly   266 DARVKLMNEIIGAIQVIKMYAWEKSFGRLIAAVRQSEVKAIRGSMSIYAALQCTNM-ISKISLFL 329

  Fly   337 SLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLH-----EE 396
            |||.:|.:|.|:||:|.|::::||.:|.:::..|:||.|:.:|:.|||.||:..|:|.     ||
  Fly   330 SLVAYVYVGDLVTAKKVFILSSYYGLLNDSLLHYWPMAITTWAQTLVSARRVVEFLLQVEKPTEE 394

  Fly   397 TKVRDK-SEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNT 460
            :..||. ..:||.:|         |..|| :|.|......|.    .:...|:.|.||:.:....
  Fly   395 SCCRDNPGLELDAEK---------PKPAQ-SGRLHCVQSETK----CLSFRKVSASWDKPSIKQP 445

  Fly   461 ----LDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGT 521
                ::.||......|.|.::|.||||||:|:.|:|||:....|.|:|:|.:|||:|:||:|.|:
  Fly   446 RKPHIEGISFHINAGQFVGIVGNVGSGKSTLLHAILGEIELMQGRVEVHGRISYAAQQPWVFQGS 510

  Fly   522 VRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKA 586
            :|:||||....::.|||.||..|.|:||.||||..|.|:|||||.||||||||||:|||||||:|
  Fly   511 IRENILFVEQYEEKRYRAVVHACQLDRDLELLPRGDATVVGERGISLSGGQKARIALARAVYRQA 575

  Fly   587 DIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYE 651
            ||||.||||:|||..||:.|.|:|....|..::.:||||.:|.|:..|.:::::.||::..|:||
  Fly   576 DIYLFDDPLAAVDAQVGKLLMDKCFHRLLDGKMRILVTHHVQLLKSVDQLLLLEGGKLTQQGSYE 640

  Fly   652 SMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQ 716
                   :...::|..:..|..|.:| ||:.:.|..|:: ||.....|.....:....:......
  Fly   641 -------ELKDVITHHAALDLEAIEA-DKQQVKRVLSQV-DRTSKQLSKGEEKDPATIQDENGNA 696

  Fly   717 EGRVEGRIGMKLYKKYFGANG--YGLFIVFAFFCIGAQVLASG----GDIFLSYWVNKNGEAERD 775
            |.:::|.:....||.||.|.|  :.:.:|.:.|     |||.|    .|||:|.|..    .|.|
  Fly   697 EQQLQGAVSYDTYKAYFRALGAPFLVCLVLSMF-----VLARGCQAVMDIFISRWAT----WEED 752

  Fly   776 TFMARLRRAFPETRINADTDPVDIY---------YFTGINVSVIIFSLVRSMLFFYLAMRSSTTL 831
                   |.:         |.||.|         ::|.:.:..:...|:|:..||::.:|.|.||
  Fly   753 -------RGY---------DSVDDYEATRTKMVIWYTVLLLLTLALFLLRTFGFFFMCLRISLTL 801

  Fly   832 HNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINV 896
            |:.::.|:.||.|:|||.|||||:|||||.|:..||..||..|||.:|..:.:|.::|::.|.|.
  Fly   802 HDQLYHGIIRAWMYFFNANPSGRVLNRFSSDIQNVDVNLPQAMMDSLQFLVDVVAVLVIVAIANY 866

  Fly   897 WYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEF 961
            |.::....:||:.|..|..|:..||.:||:|::||||||||.:.:.:|.:|||:..|..:|...|
  Fly   867 WLLIPAAIMVILLYFCRALYIGASRSLKRIESLTRSPIYSHTNQTFHGHSTIRSMDAMPQLEQTF 931

  Fly   962 DNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPE-NGGDVGLAITQAMGMTGM 1025
            ..:|:.:||..:::::.:|||.:|.|.:||:||..:|.||.:.:.. ..|||||||||:|.:..|
  Fly   932 HGHQNTNSSALFLYVSANRAFSFWTDLICVIYILAVTFSFLVINQSFYSGDVGLAITQSMTLVIM 996

  Fly  1026 VQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKA 1090
            .||||||:||:||.||:||||:||.....|...||..:.....:||:.|.:.|.||.::|.|  .
  Fly   997 CQWGMRQTAEMENNMTSVERVLEYAQTPSEPPLESPKSVNLAAEWPQAGHLRFQDLRMRYSP--G 1059

  Fly  1091 ADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKIS 1155
            .:.:||.||...:..||:||||||||||||:|.|||||:.|||.|.||..|...||||||||:||
  Fly  1060 DEDILRGLNFESQPMEKIGIVGRTGAGKSSIIQALFRLALNEGTIEIDGLDIGKLGLHDLRSRIS 1124

  Fly  1156 IIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQ 1220
            ||||:|||||||:|:|||||||.||..||.:|::||||:.||.|..||..::.:||:|||:||||
  Fly  1125 IIPQDPVLFSGTLRFNLDPFDEKSDESLWSALDDVKLKKHVASLEGGLSCRMQDGGSNFSMGQRQ 1189

  Fly  1221 LVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMD 1285
            ||||||||||:||:|||||||||||.:||.|||.||:.||.:|||||||||||||||:|.|||||
  Fly  1190 LVCLARAILRQNRVLVMDEATANVDTETDILIQETIQTKFAECTVLTIAHRLHTVMDNDSVLVMD 1254

  Fly  1286 AGKAVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQKVGLR 1332
            ||:.||||:|.:||...:..:. .:|.|...:|...|.::|.:..:|
  Fly  1255 AGQIVEFGAPHKLLQRKDGALL-KLVNQNDATTVKFLKRIASESYMR 1300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 570/1313 (43%)
ABC_membrane 98..367 CDD:294371 107/268 (40%)
ABCC_MRP_domain1 443..643 CDD:213217 99/203 (49%)
ABC_membrane 799..1027 CDD:294371 93/237 (39%)
ABCC_MRP_domain2 1074..1295 CDD:213211 148/220 (67%)
CG10505NP_611571.2 CFTR_protein 12..1268 CDD:273530 569/1312 (43%)
ABC_membrane 95..360 CDD:294371 107/268 (40%)
ABCC_MRP_domain1 428..632 CDD:213217 99/203 (49%)
ABC_membrane 728..994 CDD:294371 108/290 (37%)
ABCC_MRP_domain2 1045..1264 CDD:213211 148/220 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45440890
Domainoid 1 1.000 179 1.000 Domainoid score I1056
eggNOG 1 0.900 - - E2759_KOG0054
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 133 1.000 Inparanoid score I246
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 1 1.000 - - FOG0001028
OrthoInspector 1 1.000 - - otm14754
orthoMCL 1 0.900 - - OOG6_100026
Panther 1 1.100 - - P PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
109.800

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