DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc4

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001007039.2	Gene:	abcc4 / 368620	ZFINID:	ZDB-GENE-030616-511	Length:	1331	Species:	Danio rerio

Alignment Length:	1340	Identity:	605/1340 - (45%)
Similarity:	871/1340 - (65%)	Gaps:	54/1340 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAW 65
            |:.:|.| ...||...:|:||.:.||:..|.|..|.|:.|:|:|::..|.|.||..||.:|.:.|
Zfish     5 MEPIKKD-AKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYW 68

  Fly    66 EKEVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEG 130
            ::|.||..|:.|||.|.||.:..:....|.|| |..::|...:|.||:|||.|:.|:.:..:.:.
Zfish    69 DQEKEKAAKELKTPKLTKAIIRCYWKSYAVLG-VFTLIEESIKVIQPVFLGKLIKYFENYRHDDM 132

  Fly   131 DNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQ 195
            ...::||.||.||.|::....|..|.|...:...|||.||||..|||||||.||..|:|.||.||
Zfish   133 AALSEAYGYATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQ 197

  Fly   196 VVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKT 260
            :|||:||||.:.|...|.:::||:||::...:..|:::|||.|...|:||::..:|||...||..
Zfish   198 IVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMFGKLF 262

  Fly   261 SVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSF 325
            |..|.|||..||.|:|.|||::|||::|||||||.||:.::|.||.||::.|.:.:|:||...:.
Zfish   263 SKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYLRGLNMAS 327

  Fly   326 IMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQT 390
            .....:|.:||:...:||:|..::|.:.||..:.|:.:|.|:|::||..|.:.:|..:|||||:.
Zfish   328 FFTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISIRRIKK 392

  Fly   391 FMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQK 455
            |:|.:|..........:|:|                             |.|:.:..|...||:.
Zfish   393 FLLLDELVKNHLPLSQEEKK-----------------------------EPSVEMQDLICYWDKT 428

  Fly   456 NTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTG 520
            ....||.|:....||.||:|||||||:|||||:..|||||..:.|.:||.|.|:||||:||:|.|
Zfish   429 LDAPTLQNVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPG 493

  Fly   521 TVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRK 585
            |:|.|||||..:...||..|::.|||:||.||||..|.|::|:|||:||||||||::||||||:.
Zfish   494 TIRSNILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQD 558

  Fly   586 ADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY 650
            ||||||||||||||..|.||||:||:.|.|:::..:|||||||:|:.|:.|:::.:|.:.|.|:|
Zfish   559 ADIYLLDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSY 623

  Fly   651 ESMAKSGLDFAQMLTDPSKKDEGA--GDAP-DKKSLSRQNSKLRDRHGSISSMESAAESLAAESP 712
            ..:.:|||||..:|....:::.|:  |:|| ..:|.:...:.:|....|:.|::..::.|.|| |
Zfish   624 SELQQSGLDFTSLLKKDEEEESGSEKGEAPRSPRSRTVSQNSVRSHSSSVLSVKDDSDQLPAE-P 687

  Fly   713 MQT--QEGRVEGRIGMKLYKKYF--GANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAE 773
            :.|  :|.|.||.||:::|.|||  ||| ..:.::.....:.||......|.:||||..:..:.:
Zfish   688 VHTMAEELRSEGNIGIRMYWKYFRAGAN-VVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLD 751

  Fly   774 RDTFMARLRRAFPETRINADTDPVDIYYFTGINV----SVIIFSLVRSMLFFYLAMRSSTTLHNT 834
            .:|......    .|.....|..:|:.::.||..    :.|:|..:|.::.|...:.|:..|||.
Zfish   752 HNTNNTNTN----NTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVSSAEMLHNR 812

  Fly   835 MFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYI 899
            ||..:.|..:.||:.||.||||||||||:|.:|.:||...:|.:|:||.|||::.|...:..|.:
Zfish   813 MFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWIL 877

  Fly   900 LATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNY 964
            :..:.|:|.|..||.::|.|||||||:|:.||||::||||:||.||.|||||.|::.....||.:
Zfish   878 IPVLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAH 942

  Fly   965 QDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPE-NGGDVGLAITQAMGMTGMVQW 1028
            ||:||..:::||.|||.|...||.:|.|::.:......|.... |.||||||::.|:.:.||.||
Zfish   943 QDLHSEAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALSYAVTLMGMFQW 1007

  Fly  1029 GMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADY 1093
            |:|||||:||.||:|||||||.:||.|..:|::  |:|..|||..|.|.||.::..|..|  ...
Zfish  1008 GVRQSAEVENMMTSVERVVEYTELESEAPWETQ--KRPSPDWPNRGLITFDRVNFSYSSD--GPV 1068

  Fly  1094 VLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIP 1158
            ||::::......|||||||||||||||||:||||||..||.||:|...|:::||||||.|:||||
Zfish  1069 VLKNISAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGLHDLRQKMSIIP 1133

  Fly  1159 QEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVC 1223
            |:||||:||||.|||||:::||..||::||||:||..|.:||..|:::::|.|:|||||||||||
Zfish  1134 QDPVLFTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVC 1198

  Fly  1224 LARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGK 1288
            |||||||:||:|::|||||||||:||.|||.|||:|||:||||||||||:|::|||::||:|||:
Zfish  1199 LARAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGR 1263

  Fly  1289 AVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQK 1328
            ..|:.:|..|| .::..:|:.||:|||.:...:||:.|::
Zfish  1264 IHEYDAPHVLL-QNQSGIFYKMVQQTGKAEATSLLQTAKQ 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	592/1299 (46%)
		ABC_membrane	98..367	CDD:294371	112/268 (42%)
		ABCC_MRP_domain1	443..643	CDD:213217	112/199 (56%)
		ABC_membrane	799..1027	CDD:294371	99/232 (43%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	139/220 (63%)
abcc4	NP_001007039.2	SunT	11..1289	CDD:331423	598/1319 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586020
Domainoid	1	1.000	219	1.000	Domainoid score	I2575
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.810