Protein Alignment Mrp5 and abcc4

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001007039.2
• Gene: abcc4 / 368620
• ZFINID: ZDB-GENE-030616-511
• Length: 1331
• Species: Danio rerio
• Alignment Length: 1340
• Identity: 605/1340 - (45%)
• Similarity: 871/1340 - (65%)
• Gaps: 54/1340 - (4%)

  Fly     1 MQSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAW 65
            |:.:|.| ...||...:|:||.:.||:..|.|..|.|:.|:|:|::..|.|.||..||.:|.:.|
Zfish     5 MEPIKKD-AKSNPSASANLFSQIFFCWLNPLFSIGSKRRLEEDDMFNVLPEDRSKKLGEELQSYW 68

  Fly    66 EKEVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEG 130
            ::|.||..|:.|||.|.||.:..:....|.|| |..::|...:|.||:|||.|:.|:.:..:.:.
Zfish    69 DQEKEKAAKELKTPKLTKAIIRCYWKSYAVLG-VFTLIEESIKVIQPVFLGKLIKYFENYRHDDM 132

  Fly   131 DNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQ 195
            ...::||.||.||.|::....|..|.|...:...|||.||||..|||||||.||..|:|.||.||
Zfish   133 AALSEAYGYATGVCLSTLGLALLHHLYFYHVQRAGMKIRIAMCHMIYRKALCLSAAAMGQTTTGQ 197

  Fly   196 VVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKT 260
            :|||:||||.:.|...|.:::||:||::...:..|:::|||.|...|:||::..:|||...||..
Zfish   198 IVNLLSNDVNKFDELTIFLHFLWVGPLQAAAVIGLLWQEIGPSCLAGMAVLVFLMPLQTMFGKLF 262

  Fly   261 SVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSF 325
            |..|.|||..||.|:|.|||::|||::|||||||.||:.::|.||.||::.|.:.:|:||...:.
Zfish   263 SKYRSKTAALTDSRIRTMNEVVSGIRIIKMYAWEKPFAMLVNDVRRKEISKIMSSSYLRGLNMAS 327

  Fly   326 IMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQT 390
            .....:|.:||:...:||:|..::|.:.||..:.|:.:|.|:|::||..|.:.:|..:|||||:.
Zfish   328 FFTANKIILFVTFTVYVLVGNTMSASRVFVAVSLYSAVRLTVTLFFPAAIEKVSESAISIRRIKK 392

  Fly   391 FMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQK 455
            |:|.:|..........:|:|                             |.|:.:..|...||:.
Zfish   393 FLLLDELVKNHLPLSQEEKK-----------------------------EPSVEMQDLICYWDKT 428

  Fly   456 NTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTG 520
            ....||.|:....||.||:|||||||:|||||:..|||||..:.|.:||.|.|:||||:||:|.|
Zfish   429 LDAPTLQNVCFTVKPGQLLAVIGPVGAGKSSLLSTVLGELPAEKGVIKVKGELTYASQQPWVFPG 493

  Fly   521 TVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRK 585
            |:|.|||||..:...||..|::.|||:||.||||..|.|::|:|||:||||||||::||||||:.
Zfish   494 TIRSNILFGKELQPQRYERVLRACALKRDMELLPDGDLTVIGDRGATLSGGQKARVNLARAVYQD 558

  Fly   586 ADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY 650
            ||||||||||||||..|.||||:||:.|.|:::..:|||||||:|:.|:.|:::.:|.:.|.|:|
Zfish   559 ADIYLLDDPLSAVDAEVSRHLFEQCVCGILKDKPRILVTHQLQYLKAANQILVLKEGHMVARGSY 623

  Fly   651 ESMAKSGLDFAQMLTDPSKKDEGA--GDAP-DKKSLSRQNSKLRDRHGSISSMESAAESLAAESP 712
            ..:.:|||||..:|....:::.|:  |:|| ..:|.:...:.:|....|:.|::..::.|.|| |
Zfish   624 SELQQSGLDFTSLLKKDEEEESGSEKGEAPRSPRSRTVSQNSVRSHSSSVLSVKDDSDQLPAE-P 687

  Fly   713 MQT--QEGRVEGRIGMKLYKKYF--GANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAE 773
            :.|  :|.|.||.||:::|.|||  ||| ..:.::.....:.||......|.:||||..:..:.:
Zfish   688 VHTMAEELRSEGNIGIRMYWKYFRAGAN-VVMLVLLLLLNLLAQTFYILQDWWLSYWATEQEKLD 751

  Fly   774 RDTFMARLRRAFPETRINADTDPVDIYYFTGINV----SVIIFSLVRSMLFFYLAMRSSTTLHNT 834
            .:|......    .|.....|..:|:.::.||..    :.|:|..:|.::.|...:.|:..|||.
Zfish   752 HNTNNTNTN----NTSAGNTTQQLDLNFYLGIYAGLTGATIVFGFMRCLIMFNALVSSAEMLHNR 812

  Fly   835 MFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYI 899
            ||..:.|..:.||:.||.||||||||||:|.:|.:||...:|.:|:||.|||::.|...:..|.:
Zfish   813 MFNSILRTPVRFFDINPIGRILNRFSKDIGHLDSLLPWTFVDFIQVFLQIVGVIAVASSVIPWIL 877

  Fly   900 LATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNY 964
            :..:.|:|.|..||.::|.|||||||:|:.||||::||||:||.||.|||||.|::.....||.:
Zfish   878 IPVLPLLICFLFLRRYFLRTSRDVKRIESTTRSPVFSHLSSSLQGLWTIRAFKAEERFQQTFDAH 942

  Fly   965 QDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPE-NGGDVGLAITQAMGMTGMVQW 1028
            ||:||..:::||.|||.|...||.:|.|::.:......|.... |.||||||::.|:.:.||.||
Zfish   943 QDLHSEAWFLFLTTSRWFAVRLDGMCSVFVTITAFGCLLLKDTMNAGDVGLALSYAVTLMGMFQW 1007

  Fly  1029 GMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADY 1093
            |:|||||:||.||:|||||||.:||.|..:|::  |:|..|||..|.|.||.::..|..|  ...
Zfish  1008 GVRQSAEVENMMTSVERVVEYTELESEAPWETQ--KRPSPDWPNRGLITFDRVNFSYSSD--GPV 1068

  Fly  1094 VLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIP 1158
            ||::::......|||||||||||||||||:||||||..||.||:|...|:::||||||.|:||||
Zfish  1069 VLKNISAMFRPREKVGIVGRTGAGKSSLISALFRLSEPEGKILVDGVLTSEIGLHDLRQKMSIIP 1133

  Fly  1159 QEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVC 1223
            |:||||:||||.|||||:::||..||::||||:||..|.:||..|:::::|.|:|||||||||||
Zfish  1134 QDPVLFTGTMRKNLDPFNQHSDHDLWKALEEVQLKAAVEELPGKLETELAESGSNFSVGQRQLVC 1198

  Fly  1224 LARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGK 1288
            |||||||:||:|::|||||||||:||.|||.|||:|||:||||||||||:|::|||::||:|||:
Zfish  1199 LARAILRKNRVLIIDEATANVDPRTDELIQKTIRDKFKECTVLTIAHRLNTIIDSDRILVLDAGR 1263

  Fly  1289 AVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQK 1328
            ..|:.:|..|| .::..:|:.||:|||.:...:||:.|::
Zfish  1264 IHEYDAPHVLL-QNQSGIFYKMVQQTGKAEATSLLQTAKQ 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	569/1247 (46%)
abcc4	NP_001007039.2	MRP_assoc_pro	11..1289	CDD:188098	598/1319 (45%)