DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and ABCC6

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:XP_024306029.1 Gene:ABCC6 / 368 HGNCID:57 Length:1515 Species:Homo sapiens


Alignment Length:1405 Identity:462/1405 - (32%)
Similarity:702/1405 - (49%) Gaps:179/1405 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SMKADE---LPENPREKSN--------IFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDH 56
            |..||:   .||:| ::||        ..|...|.:.....::|.::.|...||:...:|:.|:.
Human   196 SCLADQPPFFPEDP-QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEE 259

  Fly    57 LGSKLSAAW----------EKEVEKKRK---KKKTPS--------------LLKASMNVFGWRLA 94
            |.|:|...|          .|.:..|||   ..|.|.              ||||...||.....
Human   260 LVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 324

  Fly    95 GLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYML 159
             ||.:..|:...||.|.|..|...:.:..|..    ....|.||.|:.:.|::....||....|.
Human   325 -LGTLSLIISDVFRFTVPKLLSLFLEFIGDPK----PPAWKGYLLAVLMFLSACLQTLFEQQNMY 384

  Fly   160 GMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEI 224
            .:..:.|:.|.|:|.::|||.|.||..:...:.:|.||||:|.||.||..||:::|.|||..|.|
Human   385 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWI 449

  Fly   225 GIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIK 289
            .:....:::.:|.||...:||.|..:||..::.||.:..:.:...:.|.|.|:.:.|:...:.||
Human   450 VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 514

  Fly   290 MYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVF-VSLVGF----VLLGKLLT 349
            .:.||..|...:..:|.:|:.|:|.    .|.|.|..:...::|.| |:||.|    ::....:.
Human   515 FHGWEGAFLDRVLGIRGQELGALRT----SGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMN 575

  Fly   350 AEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKA 414
            ||||||.....||| |....:.|..|....:..||..|:.||:..||                  
Human   576 AEKAFVTLTVLNIL-NKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE------------------ 621

  Fly   415 GLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGP 479
               .:|      ||:..||..::..:..|.|......|.|::.. .|..|:|......|:||:||
Human   622 ---VDP------GVVDSSSSGSAAGKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGP 676

  Fly   480 VGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRC 544
            ||:|||||:.|:||||:...|.|.:.|.::|..||.|:...:|.:|:.||..:|......|::.|
Human   677 VGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEAC 741

  Fly   545 ALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQ 609
            ||:.|.:..|....|.:||:|.:||||||.|:||||||||||.:|||||||:|:|.|||:|:|:|
Human   742 ALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQ 806

  Fly   610 CM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESM--AKSGLDFAQMLTDPSKK 670
            .:  .|.|:....:||||.|..|.|||.|:::..|.|:.||:|:.:  .|..|   ..|.|.:::
Human   807 VIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL---MCLLDQARQ 868

  Fly   671 --DEGAGDA--------PDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQ--------- 716
              |.|.|:.        |...|..|:....|:|     |::|..|.....|..||:         
Human   869 PGDRGEGETEPGTSTKDPRGTSAGRRPELRRER-----SIKSVPEKDRTTSEAQTEVPLDDPDRA 928

  Fly   717 ------EGRVEGRIGMKLYKKYFGANG--YGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAE 773
                  :....||:...::..|..|.|  ..|:.:|.|.|  .||.:.....:||.|.:......
Human   929 GWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLC--QQVASFCRGYWLSLWADDPAVGG 991

  Fly   774 RDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQG 838
            :.| .|.||..              |:...|...::.:|:.:.::|..  ..|:|..|...:...
Human   992 QQT-QAALRGG--------------IFGLLGCLQAIGLFASMAAVLLG--GARASRLLFQRLLWD 1039

  Fly   839 VTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATV 903
            |.|:.:.||...|.|.:||||||:...||..:|..:..::   :...|::.|..::.|...||||
Human  1040 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLL---MYAFGLLEVSLVVAVATPLATV 1101

  Fly   904 FLVIVFYLLRVF---YLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQ 965
            .::.:|.|...|   |:.:|..::|||:.:.|.:.||::.:..|...:|||..|...:|:.:...
Human  1102 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARV 1166

  Fly   966 DMHSSGYYMFLATSRAFGYWLDCVCV-----VYIAVITLSFFLFSPENGGDVGLAITQAMGMTGM 1025
            |......:..|...|    ||.....     :..|..|.:....:..:.|.||.:::.|:.:|..
Human  1167 DESQRISFPRLVADR----WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQT 1227

  Fly  1026 VQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPN--KKPPKDWPEDGKIVFDDLSLKYFPD 1088
            :||.:|...:|||::.:|||:.:|.....|..:. .|.  .:||  ||:.|:|.|.|..|:|.|:
Human  1228 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWR-LPTCAAQPP--WPQGGQIEFRDFGLRYRPE 1289

  Fly  1089 KAADYVLRSLNIAIEGC-------EKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDL 1145
                     |.:|::|.       ||||||||||||||||.:.|.|| ...||.|.||......:
Human  1290 ---------LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHV 1345

  Fly  1146 GLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEG 1210
            |||.|||:||||||:|:||.|::|.|||...|:||..:|.:||.|:||.:||.||..||.|.::.
Human  1346 GLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADR 1410

  Fly  1211 GTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV 1275
            |.:.||||:||:|||||:||:.:||::|||||.|||.|:..:|..:.:.|..||||.|||||.:|
Human  1411 GEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSV 1475

  Fly  1276 MDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||..:|||||.|:..|.|||.:||  ::|.:|:.:.:::|
Human  1476 MDCARVLVMDKGQVAESGSPAQLL--AQKGLFYRLAQESG 1513

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 453/1376 (33%)
ABC_membrane 98..367 CDD:294371 85/273 (31%)
ABCC_MRP_domain1 443..643 CDD:213217 90/201 (45%)
ABC_membrane 799..1027 CDD:294371 58/235 (25%)
ABCC_MRP_domain2 1074..1295 CDD:213211 117/228 (51%)
ABCC6XP_024306029.1 SunT 14..1514 CDD:331423 462/1405 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165151602
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.650

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