Protein Alignment Mrp5 and ABCC6

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001162.5
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1503
• Species: Homo sapiens
• Alignment Length: 1405
• Identity: 462/1405 - (32%)
• Similarity: 702/1405 - (49%)
• Gaps: 179/1405 - (12%)

  Fly     3 SMKADE---LPENPREKSN--------IFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDH 56
            |..||:   .||:| ::||        ..|...|.:.....::|.::.|...||:...:|:.|:.
Human   184 SCLADQPPFFPEDP-QQSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEE 247

  Fly    57 LGSKLSAAW----------EKEVEKKRK---KKKTPS--------------LLKASMNVFGWRLA 94
            |.|:|...|          .|.:..|||   ..|.|.              ||||...||.....
Human   248 LVSRLEKEWMRNRSAARRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFL 312

  Fly    95 GLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYML 159
             ||.:..|:...||.|.|..|...:.:..|..    ....|.||.|:.:.|::....||....|.
Human   313 -LGTLSLIISDVFRFTVPKLLSLFLEFIGDPK----PPAWKGYLLAVLMFLSACLQTLFEQQNMY 372

  Fly   160 GMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEI 224
            .:..:.|:.|.|:|.::|||.|.||..:...:.:|.||||:|.||.||..||:::|.|||..|.|
Human   373 RLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWI 437

  Fly   225 GIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIK 289
            .:....:::.:|.||...:||.|..:||..::.||.:..:.:...:.|.|.|:.:.|:...:.||
Human   438 VVCFVYLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 502

  Fly   290 MYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVF-VSLVGF----VLLGKLLT 349
            .:.||..|...:..:|.:|:.|:|.    .|.|.|..:...::|.| |:||.|    ::....:.
Human   503 FHGWEGAFLDRVLGIRGQELGALRT----SGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMN 563

  Fly   350 AEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKA 414
            ||||||.....||| |....:.|..|....:..||..|:.||:..||
Human   564 AEKAFVTLTVLNIL-NKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE------------------ 609

  Fly   415 GLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGP 479
               .:|      ||:..||..::..:..|.|......|.|::.. .|..|:|......|:||:||
Human   610 ---VDP------GVVDSSSSGSAAGKDCITIHSATFAWSQESPP-CLHRINLTVPQGCLLAVVGP 664

  Fly   480 VGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRC 544
            ||:|||||:.|:||||:...|.|.:.|.::|..||.|:...:|.:|:.||..:|......|::.|
Human   665 VGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEAC 729

  Fly   545 ALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQ 609
            ||:.|.:..|....|.:||:|.:||||||.|:||||||||||.:|||||||:|:|.|||:|:|:|
Human   730 ALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQ 794

  Fly   610 CM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESM--AKSGLDFAQMLTDPSKK 670
            .:  .|.|:....:||||.|..|.|||.|:::..|.|:.||:|:.:  .|..|   ..|.|.:::
Human   795 VIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGAL---MCLLDQARQ 856

  Fly   671 --DEGAGDA--------PDKKSLSRQNSKLRDRHGSISSMESAAESLAAESPMQTQ--------- 716
              |.|.|:.        |...|..|:....|:|     |::|..|.....|..||:
Human   857 PGDRGEGETEPGTSTKDPRGTSAGRRPELRRER-----SIKSVPEKDRTTSEAQTEVPLDDPDRA 916

  Fly   717 ------EGRVEGRIGMKLYKKYFGANG--YGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAE 773
                  :....||:...::..|..|.|  ..|:.:|.|.|  .||.:.....:||.|.:......
Human   917 GWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLC--QQVASFCRGYWLSLWADDPAVGG 979

  Fly   774 RDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQG 838
            :.| .|.||..              |:...|...::.:|:.:.::|..  ..|:|..|...:...
Human   980 QQT-QAALRGG--------------IFGLLGCLQAIGLFASMAAVLLG--GARASRLLFQRLLWD 1027

  Fly   839 VTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATV 903
            |.|:.:.||...|.|.:||||||:...||..:|..:..::   :...|::.|..::.|...||||
Human  1028 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLL---MYAFGLLEVSLVVAVATPLATV 1089

  Fly   904 FLVIVFYLLRVF---YLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQ 965
            .::.:|.|...|   |:.:|..::|||:.:.|.:.||::.:..|...:|||..|...:|:.:...
Human  1090 AILPLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARV 1154

  Fly   966 DMHSSGYYMFLATSRAFGYWLDCVCV-----VYIAVITLSFFLFSPENGGDVGLAITQAMGMTGM 1025
            |......:..|...|    ||.....     :..|..|.:....:..:.|.||.:::.|:.:|..
Human  1155 DESQRISFPRLVADR----WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQT 1215

  Fly  1026 VQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPN--KKPPKDWPEDGKIVFDDLSLKYFPD 1088
            :||.:|...:|||::.:|||:.:|.....|..:. .|.  .:||  ||:.|:|.|.|..|:|.|:
Human  1216 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWR-LPTCAAQPP--WPQGGQIEFRDFGLRYRPE 1277

  Fly  1089 KAADYVLRSLNIAIEGC-------EKVGIVGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDL 1145
                     |.:|::|.       ||||||||||||||||.:.|.|| ...||.|.||......:
Human  1278 ---------LPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHV 1333

  Fly  1146 GLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEG 1210
            |||.|||:||||||:|:||.|::|.|||...|:||..:|.:||.|:||.:||.||..||.|.::.
Human  1334 GLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADR 1398

  Fly  1211 GTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTV 1275
            |.:.||||:||:|||||:||:.:||::|||||.|||.|:..:|..:.:.|..||||.|||||.:|
Human  1399 GEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSV 1463

  Fly  1276 MDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            ||..:|||||.|:..|.|||.:||  ::|.:|:.:.:::|
Human  1464 MDCARVLVMDKGQVAESGSPAQLL--AQKGLFYRLAQESG 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	436/1303 (33%)
ABCC6	NP_001162.5	MRP_assoc_pro	14..1502	CDD:188098	462/1405 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..919		14/69 (20%)