DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and CG9270

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster

Alignment Length:	1336	Identity:	798/1336 - (59%)
Similarity:	1019/1336 - (76%)	Gaps:	68/1336 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE 68
            |:|.:|..||||.:.|||:||||||:|..||||||||:..|||.||:||:::.||.|..|.|:.|
  Fly     1 MQAKKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE 65

  Fly    69 VEK-KRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDN 132
            |.. ....||.||:::..:.||||:|...|:|:.:||:|.|.|.||.||.|:|.:....|.:|
  Fly    66 VRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDG-- 128

  Fly   133 QTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVV 197
             ..|.:|.|.:||:...:||..||.|:|:.|:.||.|:|:::.|||||||||||||||||.||||
  Fly   129 -LWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVV 192

  Fly   198 NLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSV 262
            ||||||:||.|.::||.::|||||:|:.|.:|.:|::||:::.:|:.::|||:|:|.:|.:.||.
  Fly   193 NLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSR 257

  Fly   263 LRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIM 327
            ||.:||||||:||||||||||||||||||.||.||.::|..:|..||::||.||||||||.||.:
  Fly   258 LRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEI 322

  Fly   328 FVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFM 392
            .::||::||||:||||:|..||||:||.:||:|||||.|:..:||.|:|||||::|::|||:.||
  Fly   323 TLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFM 387

  Fly   393 LHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNT 457
            :..||          |....|.|                .:.:..|.|..:.:...:|:|:..:.
  Fly   388 MRSET----------EALYLKGG----------------QTNKLFEGEPLVKLQSFQARWNHDHV 426

  Fly   458 DNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTV 522
            :..|:||::...|.|||||||||||||||||||:||||..:||.:||.|.:||||||||||..:|
  Fly   427 EPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASV 491

  Fly   523 RQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKAD 587
            |.||||||||||||||.|::.|||||||||| :.|:|.||||||||||||:|||||||||||:||
  Fly   492 RDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQAD 555

  Fly   588 IYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYES 652
            .|||||||||||||||||||::|||||||:::|:||||||||||.||:|||||||||||:||||.
  Fly   556 TYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEE 620

  Fly   653 MAKSGLDF-------AQMLTDPSKKDEGA-GDA-PDKKSLSRQNSKLRDRHGSISSMESAAESLA 708
            |.|||.||       ||.:.|.:::...| ||: .||.:.|||:|::  ...|::|::|:.||:.
  Fly   621 MLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRV--SRVSVTSVDSSTESIL 683

  Fly   709 AESPMQTQEGRVEGRIGMKLYKKYFGA-NGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEA 772
            .......||.|.:|:||:.:|.|||.| :|:.:.|:.||||:|.|:||||||.|||||| ||.::
  Fly   684 DNERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWV-KNNDS 747

  Fly   773 ERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQ 837
            ...|                     |||.|:|||.:::||:|:|::|||.:||.|||.|||||||
  Fly   748 SSST---------------------DIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQ 791

  Fly   838 GVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILAT 902
            ||:|.|::||:.||||||||||:.||||||||||:||:|.:||||.|.||:.||||.|.||::.|
  Fly   792 GVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINT 856

  Fly   903 VFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDM 967
            :.:.:.|:.||.||||||||:|||||:.|||:|||.||:||||:||||..||..|..|:|||||:
  Fly   857 ITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDI 921

  Fly   968 HSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSP--ENGGDVGLAITQAMGMTGMVQWGM 1030
            ||||||.||:|:|||||:||..||.|:..:||..: |:|  :|.|.:||.|||||.|||.|||||
  Fly   922 HSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSY-FNPPVDNPGQIGLVITQAMSMTGTVQWGM 985

  Fly  1031 RQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVL 1095
            ||||||||:||:||||:||..||.||:|||..:||||.:||::|.|..:.|||:|.||..||.||
  Fly   986 RQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVL 1050

  Fly  1096 RSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIPQE 1160
            :|||..|...||:|||||||||||||||||||||||||:::||..|...:|||||||||||||||
  Fly  1051 KSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQE 1115

  Fly  1161 PVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLA 1225
            |||||||:|.|||||::|:|.||||:||||.||..|::||:||:|.::|||:|:|||||||||||
  Fly  1116 PVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLA 1180

  Fly  1226 RAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAV 1290
            ||||||||||||||||||||||||||||:|||.||:|||||||||||:|::|||:|:|:|||..|
  Fly  1181 RAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLV 1245

  Fly  1291 EFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVA 1326
            ||||||||||.|..|||:.||.|||.|:|:.|||:|
  Fly  1246 EFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLKLA 1281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	778/1300 (60%)
		ABC_membrane	98..367	CDD:294371	152/268 (57%)
		ABCC_MRP_domain1	443..643	CDD:213217	143/199 (72%)
		ABC_membrane	799..1027	CDD:294371	145/229 (63%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	164/220 (75%)
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	781/1305 (60%)
		ABC_membrane	92..362	CDD:294371	153/272 (56%)
		ABCC_MRP_domain1	412..611	CDD:213217	143/199 (72%)
		ABC_membrane	718..981	CDD:294371	168/285 (59%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	164/220 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440872
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810