DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and CG31792

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001260548.1	Gene:	CG31792 / 35163	FlyBaseID:	FBgn0051792	Length:	1323	Species:	Drosophila melanogaster

Alignment Length:	1340	Identity:	773/1340 - (57%)
Similarity:	997/1340 - (74%)	Gaps:	43/1340 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQSMKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAW 65
            |||.|.::|||||||:|||||:|.|.:.:|||.||:|.||...||||||:|||::.||:||.::|
  Fly     1 MQSFKNEDLPENPRERSNIFSALSFWYTIPTFIKGQKVTLGAKDLYRALKEHRAESLGNKLCSSW 65

  Fly    66 EKEVEKKRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEG 130
            ..|:|   ..||..|||:....|||.....||||||.||:...| ||:||..|::.:   ||...
  Fly    66 ANELE---TNKKNASLLRVLFRVFGRYFVFLGLVLFCLEVILTV-QPMFLMKLISSF---SNPSP 123

  Fly   131 DNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQ 195
            .:...||.||.||||.||..|:.|:||...:.|:|:|.|:.::||||||.|||::|.||:.:.|.
  Fly   124 TSNGVAYAYAGGVILGSALKVILMNPYSFAVTHLGLKIRVGVSSMIYRKCLRLTKTDLGEISTGH 188

  Fly   196 VVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKT 260
            ::||||||:||:|..:...:||||.|::..::|||||:||||:|.||:..:|||||||.|||||.
  Fly   189 IINLISNDLGRMDTFIQFTHYLWLAPLQALMVTYLMYQEIGIAAVFGMTFILLFIPLQMYLGKKI 253

  Fly   261 SVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSF 325
            |.||||||:|:|:|:|:|.|||:|||||||||||:||.||:.:.|.||:|:||:|.|.:..:.||
  Fly   254 SGLRLKTAIRSDKRMRIMTEIIAGIQVIKMYAWELPFEKMVAHARHKEINSIRHVAYAKCLIWSF 318

  Fly   326 IMFVTRISVFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQT 390
            ..|:|.:|:|:|||||||:|:.||||.||:||||||::|..||.||.:|::|.||.||||:|:|.
  Fly   319 NRFLTPVSIFLSLVGFVLMGRFLTAEVAFLITAYYNVVRTNMTAYFSVGVTQTAETLVSIKRVQK 383

  Fly   391 FMLHEETKVRDKS-------EDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKL 448
            .:|..|...:|::       |||.|   .:..|:..||      .::...:....:|..:.||:|
  Fly   384 LLLSGEVVAKDENVVSNGAEEDLQE---AREKLLVTPT------PMRAPEKPPHNSEDCVSISEL 439

  Fly   449 KAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQ 513
            ||||...:.|.||..::|:.....|||::|..||||||||||:||||..:||.::|.|::|||||
  Fly   440 KAKWTTNSPDYTLSGVNLQVHAGALVAIVGHTGSGKSSLIQAILGELRVESGEIEVTGSMSYASQ 504

  Fly   514 EPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISL 578
            |||||:||||||||||.|||:.||..||::|||||||||||..||||:|:|||||||||||||||
  Fly   505 EPWLFSGTVRQNILFGQPMDRRRYDLVVRKCALERDFELLPLKDKTILGDRGASLSGGQKARISL 569

  Fly   579 ARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGK 643
            ||:|||.|.||||||||||||:.|.|.||::|:||.||::||:|||||||||:|||.||||:.||
  Fly   570 ARSVYRDASIYLLDDPLSAVDSSVARRLFEECLRGHLRDKIVILVTHQLQFLQQADQIVIMEMGK 634

  Fly   644 ISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSM----ESAA 704
            :.|:|||||:.||||||..:|.||...:|.|.|.      ||.:|....|..|:.|:    ||..
  Fly   635 VKAVGTYESLHKSGLDFGIVLDDPVNDNEAAEDR------SRTSSITDQRRSSVKSVLSHAESCP 693

  Fly   705 ESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGL-FIVFAFFCIGAQVLASGGDIFLSYWVNK 768
            |.:..|..:..|..:: ||.|:.:|..||.|.|..| |.|...|.:.:|.|||.||.|||.||::
  Fly   694 EDVGEEQKINLQRQQL-GRNGLGVYVDYFRAGGGFLSFSVVMTFFVCSQGLASLGDYFLSPWVSR 757

  Fly   769 NGEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHN 833
            |.:.....:....:        :||.:....|.:..|.|..|:.::.||.|||.||||:|..|||
  Fly   758 NEKMVAHNYTTDAK--------DADFEMHAAYIYMLITVLSIMVTIKRSFLFFNLAMRASIQLHN 814

  Fly   834 TMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWY 898
            :||:|::||:|:|||.||:|.||||||||:|||||:||:::|.|:|.||...|.::|:.|:|..:
  Fly   815 SMFRGISRASMYFFNKNPAGSILNRFSKDMGQVDEMLPTIIMTVIQDFLLFGGNIIVIAIVNPLF 879

  Fly   899 ILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDN 963
            ::..:...||.|.||.|||.||.|||||||.||||:|||.:||||||:|||||||...|.||||.
  Fly   880 LIPALAFGIVIYYLRSFYLKTSLDVKRLEASTRSPVYSHFAASLNGLSTIRAFGAGSILEAEFDG 944

  Fly   964 YQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQW 1028
            |||||||..|||::|||||.||:|..||::||:||||||:|.|.:..|||||||||||:||.|||
  Fly   945 YQDMHSSASYMFISTSRAFAYWMDIFCVLFIAMITLSFFIFPPSSAADVGLAITQAMGLTGTVQW 1009

  Fly  1029 GMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADY 1093
            .:||||||||||.:|||::|||::||||..|:..:|||.:.|||.|||.|.:|||:|.|...::.
  Fly  1010 TVRQSAELENTMISVERMIEYEEIEPEGPLEATADKKPHESWPEQGKIEFVELSLRYEPYLKSES 1074

  Fly  1094 VLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIP 1158
            ||:||:..|:..||||||||||||||||||||||||||:|::.||.:||||:|||||||||||||
  Fly  1075 VLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVRIDDKDTNDMGLHDLRSKISIIP 1139

  Fly  1159 QEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVC 1223
            |||||||||:|:||||||||||.:||.:||||:||.|||.:.:||::||:|||:|||||||||||
  Fly  1140 QEPVLFSGTVRHNLDPFDEYSDDRLWCALEEVELKDVVASVATGLETKITEGGSNFSVGQRQLVC 1204

  Fly  1224 LARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGK 1288
            |||||||:||||||||||||||||||||||.||||||::|||||:||||||:||||:|||||||:
  Fly  1205 LARAILRDNRILVMDEATANVDPQTDALIQATIRNKFRECTVLTVAHRLHTIMDSDRVLVMDAGR 1269

  Fly  1289 AVEFGSPFELLTTSEKKVFHSMVKQTGDSTFDALLKVAQK 1328
            .||||:|:||||..:...|..:|||||.:|:|.|||::|:
  Fly  1270 VVEFGTPYELLTADDTNAFQDLVKQTGQATYDTLLKISQR 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	752/1299 (58%)
		ABC_membrane	98..367	CDD:294371	148/268 (55%)
		ABCC_MRP_domain1	443..643	CDD:213217	136/199 (68%)
		ABC_membrane	799..1027	CDD:294371	138/227 (61%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	170/220 (77%)
CG31792	NP_001260548.1	CFTR_protein	12..1281	CDD:273530	752/1299 (58%)
		ABC_membrane	94..360	CDD:294371	149/269 (55%)
		ABCC_MRP_domain1	434..634	CDD:213217	136/199 (68%)
		ABC_membrane	736..980	CDD:294371	133/251 (53%)
		ABCC_MRP_domain2	1055..1276	CDD:213211	170/220 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440874
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810