DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and MRP

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_723772.2	Gene:	MRP / 34686	FlyBaseID:	FBgn0032456	Length:	1549	Species:	Drosophila melanogaster

Alignment Length:	1410	Identity:	486/1410 - (34%)
Similarity:	748/1410 - (53%)	Gaps:	176/1410 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ADELP----------ENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSK 60
            ||.:|          |.|...::..|.:.:.:......||.:..|:|.||:....:.....:...
  Fly   208 ADGMPRQTKYQRGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPI 272

  Fly    61 LSAAWEKEVEKKRKKKK--------------------------------TPSLLKASMNVFGWRL 93
            .:..|.:.|.|..|.|.                                .|.:.|:...||   |
  Fly   273 FAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVF---L 334

  Fly    94 AGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYM 158
            .|..:.||...:.|  .||..| .|:..:.:|  |:.:.:.|..|||:.:.:.:|.....:..|.
  Fly   335 FGALMKLFTDTLTF--AQPQVL-SLIISFVEA--QDAEPEWKGILYAVLLFVLAAAQTFILGQYF 394

  Fly   159 LGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVE 223
            ..||.:|::.|.|:.:.|||||||:|.:...::|:|::|||::.|..|......::|.:|..|::
  Fly   395 HRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQ 459

  Fly   224 IGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVI 288
            ||:..|.:::::|.|...|:|||::.||:...:..:....:::.....||||::|||::|||:|:
  Fly   460 IGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVL 524

  Fly   289 KMYAWEIPFSKMINYVRTKEMNAIRNVNYIR-GT--LQSFIMFVTRISVFVSLVGFVLLGKL--L 348
            |:||||..|.|.:..:|.||:..:|:..|:. ||  |.|...|:..:..|.:   :||..:.  |
  Fly   525 KLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFAT---YVLTSEANQL 586

  Fly   349 TAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGK 413
            :.||..|..|.:::::..:|: .||.....||..||:.||..|:         .||:||
  Fly   587 SVEKVLVSIALFDLMKLPLTI-LPMLSVDIAETQVSVNRINKFL---------NSEELD------ 635

  Fly   414 AGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIG 478
                       ...||..||:     .|.:.|...:..|   ..:.||.||:::.|...|||::|
  Fly   636 -----------PNSVLHDSSK-----PHPMSIENGEFSW---GDEITLRNINIEVKKGSLVALVG 681

  Fly   479 PVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKR 543
            .|||||||::||.|||:...:|.|...|.|:|..|:.|:...|||.|||||...|:.||..|:..
  Fly   682 TVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDA 746

  Fly   544 CALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFD 608
            |||..|.::|...|.|.:||:|.:||||||.|||||||||..||:|||||||||||.|||:|:|:
  Fly   747 CALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFE 811

  Fly   609 QCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFA----QMLTDP 667
            :.:  :|.|..:..:||||.:.||.|.|.|.::..|:||..||::.:.|:...||    |.|.:.
  Fly   812 EVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEG 876

  Fly   668 SKKDE----------GAGDAPD-------------KKSLS------------------RQNSKLR 691
            ::::|          ...|.|:             .:|||                  |:.:|.:
  Fly   877 NEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSISVTSADSLMGGGGSLRRRTKRQ 941

  Fly   692 DRHGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIG--AQVL 754
            |.|.|::|..|..:....|..:...|....|.:...:||.|.  ...|:|:..|...:.  .|..
  Fly   942 DSHDSVASAASLKKKQEVEGKLIETEKSQTGGVEFAVYKHYI--KSVGIFLSVATLVLNFVFQAF 1004

  Fly   755 ASGGDIFLSYWVNKNGEAE----RDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIFSLV 815
            ..|.:::|:.|.|....|.    ||.::.                   :|...|....|:.:..|
  Fly  1005 QIGSNLWLTQWANDQNVANDTGLRDMYLG-------------------VYGAFGFGQGVLAYFAV 1050

  Fly   816 RSMLFFYL-AMRSSTTLHNTMFQGVTRAAM-HFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVM 878
               :..|| ..:::.|:||.:...:.|.:: .||:..|.||:||.||.|:..|||.||:.|...|
  Fly  1051 ---VIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFM 1112

  Fly   879 QIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLN 943
            .....::..:||:.:....::...|.:..::|..:.||::|||.:.|||:|:|||||||.|.::.
  Fly  1113 TFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVT 1177

  Fly   944 GLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIAVITLSFFLFSPEN 1008
            |.:||||:......|.|.|...|.:....|..:..:|.....|:.|..:.|...:|...|....|
  Fly  1178 GASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVLGGQTN 1242

  Fly  1009 GGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKKPPKDWPED 1073
            .|.|||:::.|:.:|..:.|.:|.|:::|..:.:|||:.||.:.:.|..:|.:.:|..||:||::
  Fly  1243 PGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQE 1307

  Fly  1074 GKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILI 1137
            |::.|.:..::|  .:..|.|||.::..|:|.||||||||||||||||..|||| :....|.|.|
  Fly  1308 GRVEFQNFQVRY--REGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISI 1370

  Fly  1138 DRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSG 1202
            |..|...:|||.|||:::||||:||||||::|.|||||:..:|.::|::||...||..|..|.:|
  Fly  1371 DGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAG 1435

  Fly  1203 LQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLT 1267
            |..:|:|||.|.|||||||||||||:||:.::||:|||||.||.:||.|||.|||.:||:|||||
  Fly  1436 LNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLT 1500

  Fly  1268 IAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVK 1312
            |||||:|::|||||:|:|.|:.:||.||.||| .:.|..|:||.|
  Fly  1501 IAHRLNTILDSDKVIVLDKGQIIEFASPTELL-DNPKSAFYSMAK 1544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	476/1380 (34%)
		ABC_membrane	98..367	CDD:294371	85/273 (31%)
		ABCC_MRP_domain1	443..643	CDD:213217	96/201 (48%)
		ABC_membrane	799..1027	CDD:294371	71/229 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	126/221 (57%)
MRP	NP_723772.2	MRP_assoc_pro	14..1548	CDD:188098	486/1410 (34%)
		ABC_membrane	338..601	CDD:279056	85/270 (31%)
		ABCC_MRP_domain1	649..848	CDD:213217	96/201 (48%)
		ABC_membrane	988..1260	CDD:279056	81/293 (28%)
		ABCC_MRP_domain2	1308..1528	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440903
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.800