Protein Alignment Mrp5 and Sur

DIOPT Version :10

• Sequence 1: NP_001262747.1
• Gene: Mrp5 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Alignment Length: 2032
• Identity: 453/2032 - (22%)
• Similarity: 729/2032 - (35%)
• Gaps: 774/2032 - (38%)

  Fly    17 SNIFSSLMFCFAMPTFFKGRKKTLDENDL-YRALQEHRSDHLGSKLSAAWEKEVEKKRKKKKTPS 80
            :..:|...|.:..|..:.|.|:.|:..|| ...|::....|....|..    ..|||:|...:||
  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYI----YTEKKKKSNSSPS 286

  Fly    81 L----LKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAY----YADASNQE-------- 129
            |    :|.|     |::..||.:|.:....|.:..||.:..:|.|    ||.||...
  Fly   287 LWYCYIKNS-----WQMFALGGILKLAGDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNEV 346

  Fly   130 -------------------GDNQTKAYLYA------------------LGVILTSACNVLFMHPY 157
                               |.|..|..:|:                  |..|...|.:....|
  Fly   347 ANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTH-- 409

  Fly   158 MLGMFHIGMKARIAMTSMIYRKALRLSRTALGDT--TIGQVVNL--------------------- 199
            :|.|  .|::.:.::..:||||:|.|:.....|:  :.|||.:.
  Fly   410 ILNM--TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVD 472

  Fly   200 ------ISNDVGRLD-------------VSVIHMNYLWLGPVEIGIITYLMYREIGISAFFG-VA 244
                  ||:|:|.:.             ..:||  |.|..|.:|.::.||:|..:||||..| :|
  Fly   473 NPSEPNISHDIGSITNHMTEDTRNIMEFFLIIH--YAWAIPFKIAVVIYLLYMNLGISAVIGSIA 535

  Fly   245 VMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEM 309
            .:::..|||.::|...|......|..||||::.:::.:.||:|||:.||:..|.|.|...|.||:
  Fly   536 CIVIMTPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKEL 600

  Fly   310 NAIRNVNYIRGTLQSFIMFVTRISVFVSLVGFVLLGKL----------LTAEKAFVITAYYNILR 364
            ..:..    ..|..:.:..:|.|:..  |:.||.||..          |.|.:.|...|.:..|.
  Fly   601 KYLNK----DATFWTLMAVLTHIATV--LITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQLT 659

  Fly   365 NTMTVYFPMGISQFAELLVSIRRIQTFMLHEE-----------TKVRDKSE-------------- 404
            ..:.: ||:.:.......||.||::.|:...|           .::..||:
  Fly   660 VPLLI-FPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNM 723

  Fly   405 ---------DLDEQKLGKAGLIAE--------------------PTVAQTTG------------- 427
                     .|:|::|.:.....|                    |:..|..|
  Fly   724 TMRTAQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLR 788

  Fly   428 -----VLKPSSRRTSEAEHSIVISKLKAKWDQKNTDN-TLDNISLK---------------FKPR 471
                 .::|...|.|..|..:..|.::|    :|||: ..|::.||               ::|:
  Fly   789 NTPYVAIRPPKMRGSVMERPVEFSVIRA----RNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQ 849

  Fly   472 ------------------QLVAVIGPVGSGKSSLIQAVLGELNPDSGSV--KVNGTLSYASQEPW 516
                              :|..|:|..||||:||:.|:|.|:...:|::  ....|:||.||:||
  Fly   850 SQMPVVQLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPW 914

  Fly   517 LFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARA 581
            |...|:|:|||||......||..|::.|||:.|.||:|..|.:|:||||.::||||:.||::|||
  Fly   915 LLNDTIRENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARA 979

  Fly   582 VYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLRE--EIVLLVTHQLQFLEQADVIVIMDKGKI 644
            :|..|::.::||||:::|..||.|:|..|:|..|::  ...:|||.||..:::|:.::.:..|::
  Fly   980 IYSSANVVIMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRV 1044

  Fly   645 SAMGTY--------------------------------------------ESMAKSGL------- 658
            .|.|:|                                            ::::|.||
  Fly  1045 EACGSYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVT 1109

  Fly   659 ------------------DFAQM------------------------------------------ 663
                              ..|.|
  Fly  1110 MDANVACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMY 1174

  Fly   664 -------------------------------------------LTDPSKKDEGAGDA-------- 677
                                                       ||..|:....:||.
  Fly  1175 DVPLPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLAT 1239

  Fly   678 -----------------------------------------------------PD-KKS------ 682
                                                                 || |||
  Fly  1240 SCSSYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRS 1304

  Fly   683 -----------------------LSRQNSKLRDRHGSISSMESAAESLAAESP------------ 712
                                   ..|:::|.::.|..:|:..|.. |::.|||
  Fly  1305 NTSSESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSIL-SISEESPPVVHFPASILAT 1368

  Fly   713 ------MQTQE------------------------------------------------------ 717
                  .|::|
  Fly  1369 DGNKNETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAG 1433

  Fly   718 --GRVE--------------GRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWV 766
              ||..              |:|...:|..|..|.|..:..:|....:..|.|....||:|..|.
  Fly  1434 ESGRESMPLARLAIDTERKYGKISDDIYLMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWS 1498

  Fly   767 NKNGEAERDTFMARLRRAFPETRINADTDPVDIYYF---TGINVSVIIFSLVRSMLFFYLAMRSS 828
            |.:|.......:.    ..|     ::.|....|||   ..|:...||.:||.:....|....:.
  Fly  1499 NVHGRVASKGHVV----LHP-----SEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNAR 1554

  Fly   829 TTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI 893
            ..||:.:.|.:....:|||...|.|||:||||.|:..:|:.:.:....::|..|..:..:::...
  Fly  1555 RNLHDKLLQTILHKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVT 1619

  Fly   894 INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELI 958
            |..|.::.|:.:...:||::.||..::|:::|:|..|.||:.||||.::.|:.|||||..|....
  Fly  1620 ITPWILVLTLPICGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFT 1684

  Fly   959 AEFDNYQDMHSSGYYMFLATSRAFGYWLDCV--CVVYIAVITL---------------------- 999
            .......:.::..|.:...:.|..|..||.:  |:|::|.:|.
  Fly  1685 EILFKRLEANTIAYALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASA 1749

  Fly  1000 ---SFFLF----SPE----NGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY---- 1049
               .|..:    ||.    :...|||||...:.:...:.|.::..|::|....:|||:..|
  Fly  1750 SPSPFETYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQ 1814

  Fly  1050 -------------------------EDLEPEGDFES----------------------------- 1060
                                     ||:..|.|..|
  Fly  1815 DADADADADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIG 1879

  Fly  1061 -------------------------------------------------------------KPNK 1064
                                                                         |..:
  Fly  1880 GARGGGGDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQ 1944

  Fly  1065 KPP----KD----------------------WPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIE 1103
            .||    ||                      ||:.|.|.||::||:|...|  ..|:.:|.:.|.
  Fly  1945 LPPQQDDKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQK--QNVISNLTLKIP 2007

  Fly  1104 GCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGT 1167
            ..:::||.||||:|||||..:||. |....|.|.||..|...:...:||:::|||||:..||:.|
  Fly  2008 AGQRIGICGRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNAT 2072

  Fly  1168 MRYNLDPFDEYSDAKLWESLEEVKLKQVV-ADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRE 1231
            :|.||||...:.|.:||..||..:||:.| ..||.||.:.|.:||.|.|.|.|||:||||||||.
  Fly  2073 IRENLDPHGYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRG 2137

  Fly  1232 NRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPF 1296
            :..||:||||:.:|..|::.:.......|:..|::||||||.|::|.|:::|:|.|:.||.|:|.
  Fly  2138 SVCLVLDEATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPR 2202

  Fly  1297 ELLTTSEKKVFHSMVKQ 1313
            | |...|..||..::::
  Fly  2203 E-LQQLEGSVFRGLLEK 2218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mrp5	NP_001262747.1	MRP_assoc_pro	79..1315	CDD:188098	438/1969 (22%)
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	93/393 (24%)
		TM helix 1	301..324	CDD:350035	6/22 (27%)
		TM helix 2	385..433	CDD:350035	12/51 (24%)
		TM helix 3	480..525	CDD:350035	12/46 (26%)
		TM helix 4	526..575	CDD:350035	16/48 (33%)
		TM helix 5	587..631	CDD:350035	13/49 (27%)
		TM helix 6	648..681	CDD:350035	7/33 (21%)
		ABCC_MRP_domain1	837..1043	CDD:213217	74/205 (36%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	85/344 (25%)
		TM helix 1	1475..1496	CDD:350046	6/20 (30%)
		TM helix 2	1520..1568	CDD:350046	12/47 (26%)
		TM helix 3	1575..1620	CDD:350046	12/44 (27%)
		TM helix 4	1621..1670	CDD:350046	16/48 (33%)
		TM helix 5	1682..1727	CDD:350046	8/44 (18%)
		TM helix 6	1777..1810	CDD:350046	7/32 (22%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	99/222 (45%)