DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and CG7806

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster

Alignment Length:	1352	Identity:	410/1352 - (30%)
Similarity:	641/1352 - (47%)	Gaps:	159/1352 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 REKSNIFSSLMFCFAMPTFFKG----RKKTLDENDLYRALQEHRSDHLGSKLSAAWEKEVEKKRK 74
            ::::|:.|..:|.:..|...||    .:|..|..||..||...|   |..||..|
  Fly   227 QDEANLGSRFLFHWVQPLILKGVAGKLRKIEDLFDLPDALNITR---LSEKLHLA---------- 278

  Fly    75 KKKTPSLLKASMNVFGWRLAGLGLVLFILEI-GFRVTQPLFLGGLVAYYADASNQEGDNQTKAYL 138
            ..::.||.:|....||.....:|::..|.:: ||  ..||.||||:       .|:..:..:.|.
  Fly   279 LSQSQSLWRALHRCFGVEFYLIGILRLIADLSGF--AGPLLLGGLL-------RQDHADPNQVYY 334

  Fly   139 YALGV----ILTSACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALG-DTTIGQVVN 198
            ||||:    :|::.|...|  .:.:.|  :.||.|:.:.:.||||||.    |.| ..:...::|
  Fly   335 YALGLFGSTLLSAVCATHF--DWRMAM--VSMKMRVGVVNSIYRKALE----ARGLKESKPDLLN 391

  Fly   199 LISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVL 263
            |:|.|..|:..|.|..::.|..|.::....||:|.::|.:...||....|.||:..:|.|:..:.
  Fly   392 LMSTDTDRIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIF 456

  Fly   264 RLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMF 328
            ........|.|:....|.:.|.:.||:.|||..|...|..:|.:|:..:....|:....   :.|
  Fly   457 SSGLMTAKDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMC---VYF 518

  Fly   329 VTRISVFVSLVGF---VLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQT 390
            .....|.:.|:.|   ||:|..|.|...:...|...:|...:.. ||..::...|..|||:|:|.
  Fly   519 WATTPVLMCLLTFGVSVLMGNPLIASTTYTSVALLYMLIGPLNA-FPWVLNGLIEAWVSIKRVQQ 582

  Fly   391 FMLHEETKVRDKSEDLDEQKLGKAGLIA---EPTVAQTTGVLK--------PSSRRTSEAEHSIV 444
            .|   :....|.|...:....|..|..|   .|..|....||:        .|..:||.
  Fly   583 LM---DVPNLDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSP------ 638

  Fly   445 ISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSV---KVNG 506
                        |...:.:|::..|..|||.:.||||.||||.:.|::..|....|.|   ::..
  Fly   639 ------------TPFRMKDINVDIKAGQLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTT 691

  Fly   507 TLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGG 571
            ...|..|.|||..||:|.||::|...|:..|:||:..||||.|.::|. .|...|||.|.:||||
  Fly   692 GFGYVPQSPWLQRGTIRDNIVWGAQFDEQWYKTVLHACALEEDLQILG-GDLVGVGENGRTLSGG 755

  Fly   572 QKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVI 636
            |:||::||||||:...:|||||.||::|.||.||:...|:...|:.:..::||..:|....|:.|
  Fly   756 QRARVALARAVYQDKKVYLLDDVLSSLDAHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQI 820

  Fly   637 VIMDKGKISAMGTYESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSM- 700
            :.:..|::...   |.|.:|    .::..|....||             |...:|.|...:|:.
  Fly   821 LQVKDGQLLPS---EYMTQS----IELSLDEDADDE-------------QEPTVRRRSVELSNQY 865

  Fly   701 -ESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSY 764
             :.:.:||..|      |.|..|.:...::..|:.|....|........:..|:..:..|.:|:|
  Fly   866 DKKSLDSLLLE------ELREYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLMQLTRNLSDAWLAY 924

  Fly   765 WV-------NKNGEAERDTFMARLRRAFPETRINADTDPVDIYY---FTGINVSVIIFSLVRSML 819
            ||       :|| :...|..:.|     |......::.....:|   ||.|.||..:.:|.|:.|
  Fly   925 WVTETTLDPHKN-DTSLDHILMR-----PTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFL 983

  Fly   820 FFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLA- 883
            |.|..::::..:|..:.:.|..|..:||:....||||||||.|...||:.||.    ::.|.||
  Fly   984 FAYAGIKAAIFMHEKLLKKVMFAKFNFFDITSVGRILNRFSSDTNTVDDSLPF----ILNILLAQ 1044

  Fly   884 IVGIVVVLCI---INVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGL 945
            :.|:|..||:   ...|..|..:.:|.::..|:..|...|||:|||.:...||:|:|.:.:|.||
  Fly  1045 LAGLVGALCVSLYAMPWLGLVIIPMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGL 1109

  Fly   946 ATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVV----------YIAVITLS 1000
            .|||:..|......:|....:......    .|..|...||.....:          .:|.||.|
  Fly  1110 TTIRSMRASPRFQRDFQVKLEESIKAQ----LTQSAAQQWLALRLQLLGTLLVGGAGLLAAITAS 1170

  Fly  1001 FFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEGDFESKPNKK 1065
                ...|.|.|||.|:.|:.:||.:...:...||.|..:.||||:.:|..||.|.:  :..:.:
  Fly  1171 ----HTTNPGLVGLCISYALSITGQLGDLLHAVAETEQELVAVERIDQYLQLEEEQN--ASGSAE 1229

  Fly  1066 PPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFRLS- 1129
            ||..||..|.:.|.::.|.|....|.  .||.:....|..|::||||||||||:|::.||.|::
  Fly  1230 PPFGWPTQGVLSFREVQLSYREHLAP--ALRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAP 1292

  Fly  1130 YNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQ 1194
            ...|.|.:|:.:...|.|..||.:|.:|.|||.||.||:|.||||...:.|:::|.:::......
  Fly  1293 LTHGEIRLDQVNLKTLPLSVLRERIGVITQEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAAT 1357

  Fly  1195 VVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNK 1259
            ::.....||..|:...|.|.|.|||||:|||||:|:..:::.:||.|:|:|.::|..||..:||.
  Fly  1358 LLVQQLGGLDGKVETCGNNLSAGQRQLLCLARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNA 1422

  Fly  1260 FKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMV 1311
            ||.||:|.|||||..:...|:::|:|.|:..|.|:| :.|.:....:|:.|:
  Fly  1423 FKSCTLLFIAHRLRGLHAMDRIIVLDDGRICEEGNP-QSLASDSSTIFYGML 1473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	407/1339 (30%)
		ABC_membrane	98..367	CDD:294371	75/277 (27%)
		ABCC_MRP_domain1	443..643	CDD:213217	76/202 (38%)
		ABC_membrane	799..1027	CDD:294371	76/244 (31%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	89/221 (40%)
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	409/1349 (30%)
		ABC_membrane	328..560	CDD:294371	65/242 (27%)
		ABCC_MRP_domain1	621..827	CDD:213217	80/224 (36%)
		ABC_membrane	948..1192	CDD:279056	76/255 (30%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	89/221 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870